Objective: To evaluate the humoral immunogenicity induced by homologous and heterologousvaccination schedules through a comparison of two methods for detecting IgG antibodies againstSARS-CoV-2. Materials and methods: Serum concentrations of specific IgG antibodies targetingthe receptor-binding domain (RBD) of the SARS-CoV-2 spike protein were measured. Samples werecollected from 60 individuals who received different COVID-19 vaccination schedules establishedby the Peruvian health system. Additionally, 20 pre-pandemic serum samples were retrieved froma serum bank. An enzyme-linked immunosorbent assay (ELISA), considered the reference standardtest for such measurements, was used. Additionally, OJABIO rapid diagnostic test kit (PRO) was alsoemployed to qualitatively assess the IgG response. The sensitivity, specificity, positive predictivevalue (PPV), negative predictive value (NPV), Cohenâ...