The effect of the administration of D-Norgestrel on urinary excretion postcoital pregnanediol studied and found to not act as said progestin anovulatory at least to a limited extent delivered dose cycle.

This study is part of a research program that focuses the action of postcoital d-Norgestrel on various parameters of the genital tract. We have studied the effects of a 0.4 mg tablet., Eaten in the ovulatory phase of the cycle, the colpocitograma, rheological properties of cervical mucus and intracervical and intrauterine sperm retrieval. The results were compared with those obtained in a control group without treatment.

This study is part of a research program aimed at clarifying the mechanism of contraceptive action of d-Norgestrel on postcoital administration. We have studied the intrauterine fluid pH of a control group consisting of normal women without treatment. The results were compared with a group of patients who had ingested a tablet during Norgestrl d-ovulatory phase of the cycle.

Several parameters were studied to clarity the mechanisms of action of two long-acting injectable contraceptive progrstins: 17-a-19-hydroxynorprogesterone caproate (which contraceptive effectiveness clinically lasts at least 8 weeks) and 19-norethindrone enanthate (effectiveness over 12 weeks). The "classic" theory of ovulation-inhibition was found uncovincing. In 14 ovarian biopsies of patients under treatment, taken in the second phase of the cycle, ovulation was evident in 11 of them by presence of corpora lutea. 245 endometrial biopsies showed that exogenus gestagen effect lasts only three weeks; after this period most endometria could be correlated with the cycle-day on which they were taken: 2/3 of these suggested biphasic cycles. Evaluation of 240 colpocytograms also confirmed endogenous cyclic activity. In order to explain the long-acting contraceptive effectiveness, cervical muc...

This study is part of a research program that focuses the action of postcoital d-Norgestrel on various parameters of the genital tract. We have studied the effects of a 0.4 mg tablet., Eaten in the ovulatory phase of the cycle, the colpocitograma, rheological properties of cervical mucus and intracervical and intrauterine sperm retrieval. The results were compared with those obtained in a control group without treatment.

The effect of the administration of D-Norgestrel on urinary excretion postcoital pregnanediol studied and found to not act as said progestin anovulatory at least to a limited extent delivered dose cycle.

This study is part of a research program aimed at clarifying the mechanism of contraceptive action of d-Norgestrel on postcoital administration. We have studied the intrauterine fluid pH of a control group consisting of normal women without treatment. The results were compared with a group of patients who had ingested a tablet during Norgestrl d-ovulatory phase of the cycle.

Several parameters were studied to clarity the mechanisms of action of two long-acting injectable contraceptive progrstins: 17-a-19-hydroxynorprogesterone caproate (which contraceptive effectiveness clinically lasts at least 8 weeks) and 19-norethindrone enanthate (effectiveness over 12 weeks). The "classic" theory of ovulation-inhibition was found uncovincing. In 14 ovarian biopsies of patients under treatment, taken in the second phase of the cycle, ovulation was evident in 11 of them by presence of corpora lutea. 245 endometrial biopsies showed that exogenus gestagen effect lasts only three weeks; after this period most endometria could be correlated with the cycle-day on which they were taken: 2/3 of these suggested biphasic cycles. Evaluation of 240 colpocytograms also confirmed endogenous cyclic activity. In order to explain the long-acting contraceptive effectiveness, cervical muc...

207 highly fertile Peruvian females were studied with a long-acting hormonal contraceptive; this compound was a synthetic gestagen: Norethindrone enanthate; with a dose of 200 mg. every three months there were no pregnancies in a group of 134 patients. In 53 patients receiving the some dose every 4 months occurred 3 pregnancies, demonstrating the reversibility of the contraceptive mechanism. Side effects were observed in the first 3 months with the usual incidence for oral contraceptives, but they diminished to 2.9 % after this period of time. The authors remark the persistence of lactation and disappearance of dysmenorrhea that occurred in most of the patients.

Treatment of 1036 patients from rural (29.7 %) and urban (70.3 %) origin with norethisterone enanthate, a long term progestogen used as a contraceptive, is reported. The contraceptive effect is high, failure rate being 1.58 per 100 woman-years. Protection is extended far 12 weeks and the effect is reversible. Disturbances were present in 35.4% of the cycles, specially when treatment was started in postpartum amenorrheic, lactating women. The most frequent alteration was poli-hypermenorrhea. Intermenstrual spotting or bleeding tends to decrease after the initial months of treatment. The low incidence in inhibition of lactation as well as in general side effects, and its marked acceptability among women of low social-economic level are highly positive facts far this new contraceptive measure.

207 highly fertile Peruvian females were studied with a long-acting hormonal contraceptive; this compound was a synthetic gestagen: Norethindrone enanthate; with a dose of 200 mg. every three months there were no pregnancies in a group of 134 patients. In 53 patients receiving the some dose every 4 months occurred 3 pregnancies, demonstrating the reversibility of the contraceptive mechanism. Side effects were observed in the first 3 months with the usual incidence for oral contraceptives, but they diminished to 2.9 % after this period of time. The authors remark the persistence of lactation and disappearance of dysmenorrhea that occurred in most of the patients.

We have determined the concentration of luteinizing hormone (LH) in the blood serum of 20 women of reproductive age, with normal menstrual cycles, without any hormonal treatment, only 6 had implemented a D. l. U. With this purpose, a radioimmunoassay technique was employed. In three cycles failed to show a significant increase in LH in the middle of it. In the 17 cycles, considered biphasic, ovulatory, a higher concentration of LH in the follicular phase was found (8 93 mU / ml, expressed in units of the 2nd. IRP-HMG) in the luteal phase (7.43 mU / ml) , p = 0.025. For an average duration of 30 days, the ovulatory LH surge was presented around the 17th day of the cycle, with wide variations between the 11th and the 25th day. The luteal phase lasted on average 14 days. The average concentration of LH peak was mesocíclico 79.97 mU / ml, which represented an increase of nine times higher L...

The authors have studied the contraceptive effect of 17-Alpha Hydroxi-19-Norprogesterona Capronate (SN - 582) in 21 normal women; the effect is present during 6-8 weeks after the inyection of 200 mg. During this time menstrual irregularities as spotting and amenorrhea were observed, but their incidence was lower than those produced by the norethisterone enanthate (SN - 393).

We have determined the concentration of luteinizing hormone (LH) in the blood serum of 20 women of reproductive age, with normal menstrual cycles, without any hormonal treatment, only 6 had implemented a D. l. U. With this purpose, a radioimmunoassay technique was employed. In three cycles failed to show a significant increase in LH in the middle of it. In the 17 cycles, considered biphasic, ovulatory, a higher concentration of LH in the follicular phase was found (8 93 mU / ml, expressed in units of the 2nd. IRP-HMG) in the luteal phase (7.43 mU / ml) , p = 0.025. For an average duration of 30 days, the ovulatory LH surge was presented around the 17th day of the cycle, with wide variations between the 11th and the 25th day. The luteal phase lasted on average 14 days. The average concentration of LH peak was mesocíclico 79.97 mU / ml, which represented an increase of nine times higher L...

We have studied the oxytocic effect cervical ripening and enhancing oxytocin to 17 -Beto Estradiol applied in amniotic cavity in 10 pregnant women aged 38 or 40 weeks gestation action. Obtaining increased uterine activity due to an increase in the intensity and frequency of the contractions, cervical ripening in 50% of cases and the large increase in uterine activity when small doses of oxytocin administered, thus demonstrating the enhancing effect of this hormone oxytocin.

We have studied the oxytocic effect cervical ripening and enhancing oxytocin to 17 -Beto Estradiol applied in amniotic cavity in 10 pregnant women aged 38 or 40 weeks gestation action. Obtaining increased uterine activity due to an increase in the intensity and frequency of the contractions, cervical ripening in 50% of cases and the large increase in uterine activity when small doses of oxytocin administered, thus demonstrating the enhancing effect of this hormone oxytocin.