Introduction: An amebic liver abscess is the most common presentation of extraintestinal amebiasis. This condition is the result of a parasite infection caused by Entamoeba histolytica. Materials and Methods: We report a case of a 53-year-old male who presented with abdominal pain in the right upper quadrant, jaundice, and a 10-kg weight loss within a 1-month span. Results and Conclusion: A wide range of symptoms and findings in the imaging tests suggestive of neoplasia, elevated levels of CA 19-9 and CA 125, and the presentation of biliary peritonitis as a complication makes this case a challenge for its approach and management.

Agradecimientos: a la Dirección de la División de Estudios para Ejecutivos (EPE) de la Universidad Peruana de Ciencias Aplicadas (UPC), por facilitar el acceso a su población de estudiantes. Al Vicerrectorado de Investigación de la UPC por el apoyo para la redacción del presente artículo. Al médico Vicente Benites-Zapata (Instituto Nacional de Salud, Lima, Perú) por su revisión y sugerencias.