The authors have studied the excretion of pregnanediol in 85 normal women by using the method of Sulimovici. During the menstrual cycle the mean values ± S.E. for 12 women were 1.0 ± 0 .15 and 3.65 ± 0 .33 mg./24 hr. for the proliferative and secretory phases respectively. The mean values in 63 pregnant women were 7.54 ± 0 .32, 9.19 ± 0.65, 8 .32 ± 0.67, 12.46 ± 0.88, 21.64 ± 0.8 and 28.37 ± 0.91 mg./g. creatinine for the months 2nd., 3rd., 4th., 5th., 7th. and 10th. The procedure was compared to Kloppers method and no differences were detected. As additional proof of the specificity of the method employed, the urine extracts were analyzed by gas-liquid chromatography and, pregnanediol was found to be the principal component of the final extract.

The authors have studied the excretion of pregnanediol in 85 normal women by using the method of Sulimovici. During the menstrual cycle the mean values ± S.E. for 12 women were 1.0 ± 0 .15 and 3.65 ± 0 .33 mg./24 hr. for the proliferative and secretory phases respectively. The mean values in 63 pregnant women were 7.54 ± 0 .32, 9.19 ± 0.65, 8 .32 ± 0.67, 12.46 ± 0.88, 21.64 ± 0.8 and 28.37 ± 0.91 mg./g. creatinine for the months 2nd., 3rd., 4th., 5th., 7th. and 10th. The procedure was compared to Kloppers method and no differences were detected. As additional proof of the specificity of the method employed, the urine extracts were analyzed by gas-liquid chromatography and, pregnanediol was found to be the principal component of the final extract.

Tomo 1. Páginas [115]-117

Objectives: To determine the effect of chronic hypoxia on prolactin (PRL) secretion. Design: Comparative study. Setting: Endocrinology service, Hospital Nacional Arzobispo Loayza, Lima, Peru. Participants: Native young men from Lima and Cerro de Pasco. Interventions: Three groups of normal young men age (X24a) with comparable nutritional status, natives from different altitudes: 150 m.a.s.l. (Lima, N=10), 3 000 m.a.s.l. (Tarma, N= 10), 4 200 m.a.s.l. (Cerro de Pasco, n=11); and three patients with chronic mountain disease (CMD) natives from Cerro de Pasco were studied. All subjects were euthyroid and without goiter. RIA determinations of PRL basal serum levels and PRL response to thyrotrophin releasing hormone (TRH) 200 μg I.V. were carried out on each subject. Main outcome measures: Difference of serum prolactin levels and highest response to thyrotrophin releasing hormone in subjects ...