En Perú, el cáncer de mama está catalogado como la segunda neoplasia maligna más frecuente. Se conoce que la tasa de supervivencia a los 5 años es baja, por lo cual hoy en día se busca identificar potenciales marcadores tumorales que pudieran contribuir al pronóstico. El CD44 es una glicoproteína transmembrana que se ha visto asociada a mayor carcinogénesis y aún se encuentra en estudio para identificar su relación con el cáncer de mama. Objetivo: Identificar la asociación entre la expresión de la proteína CD44 en las células tumorales y una menor sobrevida en pacientes con cáncer de mama. Material y métodos: Estudio observacional, analítico y retrospectivo en 101 pacientes mayores de edad, pertenecientes al Instituto Nacional de Enfermedades Neoplásicas (INEN) de Lima-Perú durante mayo 2016 a mayo 2018, con diagnóstico de cáncer de mama invasivo, las muestras fuer...

Isolation as a restrictive measure during the SARS-COV-2 pandemic has generated negative effects on the population, especially on the health of older adults. A literature review was conducted using SCOPUS, Google Scholar, PubMed and Scielo databases published as of December 2019. For the results, the association of social isolation with COVID-19, physical consequences, psychological effects, neurodegenerative diseases, and assessment and management was made. The articles used provide information from a specific time period, so it is unknown what the long-term effects might be, and whether there is really a difference with the pre-pandemic health status. However, it is of utmost importance to establish measures to mitigate the effects both physically and mentally, that are adapted to the reality of each country.

El aislamiento como medida restrictiva durante la pandemia por el virus SARS-COV-2 ha generado efectos negativos en la población, especialmente en la salud de los adultos mayores. Se realizó una revisión de la literatura empleando las bases de datos de SCOPUS, Google Scholar, PubMed y Scielo publicados a partir de diciembre de 2019. Para los resultados, se hizo la asociación de aislamiento social con COVID-19, consecuencias físicas, efectos psicológicos, enfermedades neurodegenerativas, y la evaluación y manejo. Los artículos empleados brindan información de un periodo de tiempo determinado, por lo cual se desconoce cuáles podrían ser los efectos a largo plazo, y si realmente hay una diferencia con el estado de salud previo a la pandemia. Sin embargo, es de suma importancia establecer medidas para mitigar los efectos tanto a nivel físico como mental, que estén adaptadas a la...

Isolation as a restrictive measure during the SARS-COV-2 pandemic has generated negative effects on the population, especially on the health of older adults. A literature review was conducted using SCOPUS, Google Scholar, PubMed and Scielo databases published as of December 2019. For the results, the association of social isolation with COVID-19, physical consequences, psychological effects, neurodegenerative diseases, and assessment and management was made. The articles used provide information from a specific time period, so it is unknown what the long-term effects might be, and whether there is really a difference with the pre-pandemic health status. However, it is of utmost importance to establish measures to mitigate the effects both physically and mentally, that are adapted to the reality of each country.

Circulating tumor DNA (ctDNA) evaluates cellular components of cancer cells in plasma. Breast cancer (BC) is the most frequent one. Studying ctDNA is a non-invasive method to assess BC. Patients with BC have higher levels of ctDNA than those without. High ctDNA levels are more frequent in patients with metastatic disease with high tumor burden and with more aggressive disease, such as those with triple-negative phenotype and HER2+. ctDNA allows the selection of target treatment for metastatic disease. Elimination of ctDNA during neoadjuvant chemotherapy in early BC is associated with higher complete response rates and longer survival and also predicts relapses well in advance.