The clinical effects, sperm parameters and macroscopic and histological lesions caused by chemical castration in dogs through the application of sclerosing substances were evaluated. Three groups were established: (G1, n=10), 4% chlorhexidine gluconate, (G2, n=10), 4% benzalkonium chloride + 0.4% cetrimide, and (G3, control, n=5) chloride of 0.9% sodium, at a dose of 0.5-1.0 ml intra-epididymal (IEPD) and bilateral on day 0. The effects were evaluated on days 2, 7, 14, 28 and 56 post-application. The manifest oligospermia was observed in 9/10 animals of G1 (90%) and in 7/10 of G2 at day 2 post-application, with a critical decrease of sperm concentration (3.78 ± 6.3 x 106/ml and 0.95 ± 0.89 x 106/ml, respectively, motility of 0.10 ± 0.32 - 0.20 ± 0.42% with oscillatory movement, without progressive advance and vitality of 0.30 ± 0.67% - 0% in both groups. Azoospermia was detected in ...

The clinical effects, sperm parameters and macroscopic and histological lesions caused by chemical castration in dogs through the application of sclerosing substances were evaluated. Three groups were established: (G1, n=10), 4% chlorhexidine gluconate, (G2, n=10), 4% benzalkonium chloride + 0.4% cetrimide, and (G3, control, n=5) chloride of 0.9% sodium, at a dose of 0.5-1.0 ml intra-epididymal (IEPD) and bilateral on day 0. The effects were evaluated on days 2, 7, 14, 28 and 56 post-application. The manifest oligospermia was observed in 9/10 animals of G1 (90%) and in 7/10 of G2 at day 2 post-application, with a critical decrease of sperm concentration (3.78 ± 6.3 x 106/ml and 0.95 ± 0.89 x 106/ml, respectively, motility of 0.10 ± 0.32 - 0.20 ± 0.42% with oscillatory movement, without progressive advance and vitality of 0.30 ± 0.67% - 0% in both groups. Azoospermia was detected in ...