Objetivo: Determinar la función renal del receptor de Trasplante renal y su relación con las condiciones pre trasplante del donante. Materiales y métodos: Estudio descriptivo de una gran serie de casos. Se recolectaron datos de las historias clínicas en la Unidad de Trasplante Renal del Hospital Nacional Cayetano Heredia del periodo del 2007 a 2014, luego se realizó una base de datos en Microsoft Excel 2016 y esto fue transferido al software STATA versión 14. Se consideró el valor p<0.05 como estadísticamente significativo. Resultados: De un total de 86 trasplantados, se trabajó con 29 receptores y sus respectivos donantes. De las características pre trasplante del donador, la única que probablemente influyó en el la probabilidad de desarrollar disfunción de injerto en el receptor fue el sexo femenino, con tendencia a alcanzar una diferencia estadística significativa, (p= 0...

Introduction: The increase in ultra-processed foods (UPFs) intake has raised concerns about its impact on public health. Prospective observational studies have reported significant associations between higher intake of UPFs and adverse health outcomes. The aim of this study is to determine whether these associations could be confirmed in randomized controlled trials (RCTs). Methods: We conducted a systematic review to analyze the evidence on the effects of UPFs intake on health. A systematic search was conducted in Medline, Embase, Web of Science, Scopus, LILACS, and CENTRAL up to April 22, 2024. RCTs in English, Spanish, and Portuguese evaluating the health effects of interventions to modify UPFs intake were included. The certainty of evidence was determined using the GRADE methodology. Results: Three educational intervention studies and one controlled feeding trial were included, evalu...

Background and purpose: Bioavailability studies and observational evidence suggest that heme iron (HI) may have greater impact on iron status indicators compared with non-heme iron (NHI). This systematic review and meta-analysis aimed to review the current evidence on the effect of the administration of HI compared with NHI for improving iron status in non-hospitalized population groups. Methods: We searched Pubmed, CENTRAL, Scopus, Web of Science, and LILACS from inception to July 2024. There was no language restriction or exclusion based on age or iron status. Only randomized controlled trials comparing HI with NHI were considered. A random-effects meta-analysis was performed to compare the effect of treatments for iron status indicators and total side effects (including gastrointestinal side effects). We measured the certainty of the evidence (CoE) using GRADE assessment. Results: Aft...

The onset of the pandemic caused by the SARS-CoV-2 virus found the world unprepared. However, the reaction to it has been amazing. In just over a year since the virus was recognized, there are hundreds of vaccines in development, some of them already in use in many countries of the world. In this manuscript we review the current status of vaccine development, highlighting those that are under study to evaluate its efficacy or effectiveness. We also review the variants of interest and of concern of the SARS-CoV-2 virus detected until now and what is known about the efficacy of the vaccines against them.