La terapia más efectiva para el cáncer de mama avanzado con receptores hormonales positivos (HR+)/receptor 2 del factor de crecimiento epidérmico humano negativo (HER2-) aún no ha sido determinada. Por lo tanto, se realizó esta revisión sistemática para resumir la eficacia y seguridad del palbociclib más letrozol versus letrozol. Se realizó una exploración en las bases de PubMed, Embase, OVID/Medline, Web of Science y Scopus. La eficiencia de las opciones de tratamiento se midió en términos de supervivencia libre de progresión, la supervivencia general y la tasa de respuesta objetiva. En total se incluyeron tres estudios con 1267 pacientes. Los estudios PALOMA-4 y PALOMA-2 mostraron que palbociclib más letrozol prolongaba la supervivencia libre de progresión con una mediana: 21,5 frente a 13,9 meses (HR 0.68, IC 95% 0.53 - 0.87; p=0.0012) y mediana de 27.6 meses frente a 1...

Introduction: The population is susceptible to COVID-19 and knowing the most predominant characteristics and comorbidities of those affected is essential to diminish its effects. Objective: This study analyzed the biological, social and clinical risk factors for mortality in hospitalized patients with COVID-19 in the district of Trujillo, Peru. Methods: A descriptive type of study was made, with a quantitative approach and a correlational, retrospective, cross-sectional design. Data was obtained from the Ministry of Health’s database, with a sample of 64 patients from March to May 2020. Results: 85,71% of the total deceased are male, the most predominant occupation is Retired with an 28,57% incidence, and an average age of 64,67 years. When it came to symptoms of deceased patients, respiratory distress represents the highest percentage of incidence with 90,48%, then fever with 80,95%, ...

Introduction: The population is susceptible to COVID-19 and knowing the most predominant characteristics and comorbidities of those affected is essential to diminish its effects. Objective: This study analyzed the biological, social and clinical risk factors for mortality in hospitalized patients with COVID-19 in the district of Trujillo, Peru. Methods: A descriptive type of study was made, with a quantitative approach and a correlational, retrospective, cross-sectional design. Data was obtained from the Ministry of Health’s database, with a sample of 64 patients from March to May 2020. Results: 85,71% of the total deceased are male, the most predominant occupation is Retired with an 28,57% incidence, and an average age of 64,67 years. When it came to symptoms of deceased patients, respiratory distress represents the highest percentage of incidence with 90,48%, then fever with 80,95%, ...