Sepsis is one of the leading causes of mortality in adults and children. It has a negative impact on the population’s health, and the expenses for the healthcare system are estimated at several billion dollars. Infant death worldwide has represented for decades a complex and progressive inflammatory disease secondary to an infectious agent, which causes tissue dysoxia and eventually cell and organ failure, without necessarily going through hypotension in the early stages but in later stages of the disease. This review updates the definitions from the Third Consensus on Definitions of Sepsis and Septic Shock and the International Surviving Campaigns, which provide us a better understanding of the pathobiology of the disease. It aims the need to use a score of organ dysfunction in children for better appraisal and prediction of mortality, and to conduct clinical trials. The objective of ...

La sepsis es una de las principales causas de mortalidad en adultos y en niños. El impacto es negativo en la salud de la población, y los gastos generados en el sistema de salud se los calcula en varios miles de millones de dólares. La muerte infantil a nivel mundial representa por décadas una compleja y progresiva enfermedad inflamatoria secundaria a un agente infeccioso, la cual origina disoxia tisular y eventualmente falla celular y orgánica, sin necesariamente pasar por hipotensión en etapas tempranas sino en etapas tardías de enfermedad. En la presente publicación se actualiza las definiciones realizadas a partir del Tercer Consenso de Definiciones de Sepsis y Choque Séptico y las Campañas Internacionales Sobreviviendo a la Sepsis, tomando como referencia un mejor entendimiento de la patobiología de la enfermedad. Se aborda la necesidad de usar un puntaje de disfunción d...

We carried out an observational, retrospective and descriptive study in order to identify the clinical and epidemiological characteristics of children with SARS-CoV-2 infection admitted to a Peruvian national referral hospital. We included patients from one month old to fourteen years old hospitalized between March and August 2020. A total of 125 patients with SARS-CoV-2 infection were admitted, 18.4% (n = 23) had critical illness and 16.8% (n = 21) had multisystem inflammatory syndrome (MIS-C). The absence of comorbidities and previous history of epidemiological contact were more frequent in patients with MIS-C. Patients in critical condition and patients with MIS-C had lower lymphocyte and platelet counts, and higher C-reactive protein, ferritin and D-dimer values than patients who did not have said conditions. Six (4.8%) out of 125 children died, as well as 3 (13%) children from the g...