Objetivo: Determinar si el Ibuprofeno y Celecoxib disminuyen la fertilidad de ratas hembras. Diseño: Estudio experimental. Lugar: Bioterio de la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Material biológico: Ratas Sprague-Dawley adultos de 3 – 4 meses de edad, con peso 150 ±20 g. no preñadas. . Métodos: Se realizó el seguimiento del ciclo estral del total de ratas, y se distribuyó aleatoriamente, en 3 grupos: Grupo Control (n=7): Suero fisiológico 0.1ml/100g; Grupo Ibuprofeno (n=7): Ibuprofeno 120 mg/kg/12h; Grupo Celecoxib (n=8): Celecoxib 20 mg/kg/12h. El tratamiento fue iniciado en diestro y se reunieron con los machos en estro del mismo ciclo, solo hasta cumplir 10 días. Luego se mantuvieron 10 días sin tratamiento y solas, al concluir 20 días fueron eutanizadas y expuestos los úteros. Principales Medidas de Resultados: se usó el porcentaje ge...

Objective: To evaluate the effect of Ibuprofen and Celecoxib on fertility in female rats. Material and methods: 22 14-week-old Holtzman female rats were selected, which were in the diestrus stage, determined by vaginal cytology evaluation, who were distributed into three groups, and treated orally for two days, as follows: Group control: physiological saline 1 ml/100g, experimental group 1: Ibuprofen 120 mg/kg/day and experimental group 2: Celecoxib 20 mg/kg/day. After two days they were mated with the males, until the end of the next estrous cycle. The rats were euthanized 10 days after separation from the male and the presence and number of implanted embryos were evaluated. Results: The percentage of rats that did not present pregnancy was 14.3, 71.4 and 37.5% in the control, Ibuprofen and Celecoxib groups respectively; while the average number of embryos implanted were: control group ...