The efficacy of benzalkonium chloride for the treatment of dermatomicosis caused by Trichophyton sp. in guinea pig (Cavia cobayo) was evaluated in 200 guinea pigs of two months old, that showed typical clinical signs of dermatomicosis. Hair samples and skin grudges were taken for direct exam and for in vitro culture in Dermatophytes Test Medium and Mycobiotic. Skin biopsies for pathobiology were prepared. The guinea pig were divided in groups A and B of 100 animals each. Group A was treated with 0.1% aqueous benzalkonium chloride solution, whereas group B was treated with water as placebo. All samples were positive to media culture by 3rd to 7th day and Trichophyton mentagrophytes was isolated. Sixty percent of the samples were positive to direct exam. Histological study showed mild hyperkeratosis. Healing of lesions and hair growth were observed in all treated guinea pigs by the end of ...

Se evaluó la eficacia del cloruro de benzalconio en el tratamiento de la dermatomicosis causada por Trichophyton sp. en el cuy (Cavia cobayo). Se utilizó 200 cuyes de 2 meses de edad que presentaban signos clínicos de dermatomicosis. Los cuyes fueron divididos al azar en dos grupos (A y B) similares. Al grupo A se le aplicó una solución acuosa de cloruro de benzalconio al 0.1% como único tratamiento y en el grupo B se empleó agua como placebo. Previo al tratamiento, se tomaron muestras de pelos y escamas de piel para examen directo y cultivo en los medios Dermatophytes Test Medium (DTM) y Mycobiotic, así como biopsias de piel para estudio histológico. Todas las muestras resultaron positivas a hongos entre el 3º y 7º día, tipificándose la especie Trichophyton mentagrophytes con la ayuda de microcultivos y lectura en agar urea. El 60% de las muestras fueron positivas al examen...

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