Introducción: El linfoma primario de apéndice ocurre en 0,015% de todas las neoplasias malignas de apéndice. La manifestación clínica más frecuente es apendicitis aguda y el análisis anatomo patológico es muy importante. Reporte de caso: Linfoma primario de apéndice cecal, varón de 38 años, ingresó con apendicitis aguda. Estudio histopatológico macroscópico muestra pared apendicular difusamente engrosada color blanco. Microscópicamente: linfoma de alto grado Burkitt, ACL, CD20, CD10 positivo, KI 67 positivos 95%, CD3, BCL2, EBV negativo. Post operatorio: tomografía abdomino torácica mostró tumoración de fosa iliaca derecha sin lesiones ni adenopatías en abdomen y tórax. El paciente fue tratado con dos cursos de quimioterapia y se le realizó TAC abdominal control a los 6 meses, esta evidenció la tumoración inicial. A los 6 meses el paciente se encuentra estable y c...

Introduction: Primary lymphoma of the appendix occurs in 0.015% of all malignant neoplasms of the appendix. The most frequent clinical manifestation is acute appendicitis, and pathological analysis is very important. Case report: Primary lymphoma of the cecal appendix, a 38-year-old man was admitted with acute appendicitis. Macroscopic histopathological study shows diffusely thickened white appendage wall. Microscopically: high-grade Burkitt lymphoma, ACL, CD20, CD10 positive, KI 67 positive 95%, CD3, BCL2, EBV negative. Postoperative: thoracic abdominal tomography showed a tumor in the right iliac fossa without lesions or adenopathies in the abdomen and thorax. The patient was treated with two courses of chemotherapy and a control abdominal CT was performed at 6 months, which showed the initial tumor. At 6 months the patient is stable and controlled. Conclusion: The value of the histopa...

Background Obesity is a multifactorial chronic disease with a high, increasing worldwide prevalence. Genetic causes account for 7% of the cases in children with extreme obesity. Data sources This narrative review was conducted by searching for papers published in the PubMed/MEDLINE, Embase and SciELO databases and included 161 articles. The search used the following search terms: “obesity”, “obesity and genetics”, “leptin”, “Prader-Willi syndrome”, and “melanocortins”. The types of studies included were systematic reviews, clinical trials, prospective cohort studies, cross-sectional and prospective studies, narrative reviews, and case reports. Results The leptin-melanocortin pathway is primarily responsible for the regulation of appetite and body weight. However, several important aspects of the pathophysiology of obesity remain unknown. Genetic causes of obesity can ...