The indiscriminate use of antimicrobials led to the emergence of antimicrobial resistance (AMR), so the rational use of these medications becomes extremely necessary. Thus, an alternative is the use of pharmacokinetic/pharmacodynamic (PK/PD) integration, a tool used in human and veterinary medicine, to determine dosing regimen optimization. Optimizing the dosage regimen makes it possible to establish therapies with greater precision and probability of clinical success, in addition to minimizing toxicity and the spread of antimicrobial resistance. PK/PD integration studies are included in the European Medicines Agency (EMA) guidelines for evaluating medical products; however, this tool needs to be more widespread. Additionally, in 2015, the World Health Organization (WHO) established optimizing antimicrobial doses as one of the five critical points to help reduce the spread of AMR, so PK/...

The aim of this study was to develop a pharmacokinetic model of florfenicol in plasma of tilapia (Oreochromis niloticus) subjected to different rearing temperatures to estimate the plasma concentration of the protocols indicated in the package inserts of florfenicol products authorized in Brazil. For this, a pharmacokinetic model was created from previously published data on the plasma concentration of florfenicol in Nile tilapia subjected to different temperatures. The construction of the pharmacokinetic model was carried out with the Lixoft® Monolix 2020R1 program, based on the plasma pharmacokinetic data of florfenicol found in the literature. Plasma concentrations of florfenicol were estimated from treatments with doses of 10, 15 and 20 mg/kg administered every 24 hours for 10 days, at temperatures of 18, 21, 26 and 30 °C, using the Lixoft Simulx 2020 program®. The absorption lat...