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1
artículo
Publicado 2017
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The investigation’s fundamental purpose, it was focused to determine the Valor Predictivo of tamizaje’s spot tests in order to VIH;Descriptive investigation epidemiologic, retrospective and transverse; The basic procedures, 2009, 2010 and 2011 came true with the epidemiologic statistics in the sensibility and specificity tests of the years; The more important findings went than: This procedure had great acceptance for part of los/las users, since they surpassed them 33,000 you show in solidum group poblacional and tendency was maintained during the three years, referring to the sensibility average he was equivalent to the 100; Finally we come to an end than tamizaje’s spot tests in order to VIH, they have Value Predictivo Positivo, applied to the population that he proceeded to Salud’s Establishments in the Region Huánuco.
2
tesis doctoral
Publicado 2024
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El presente trabajo da a conocer los resultados de Validez y Confiabilidad del Cuestionario Salamanca para el Screening de trastornos de Personalidad, aplicados a la población universitaria peruana del contexto local con edades comprendidas entre 16 a 40 años, dando por resultado que el Alfa de Cronbach es 0.841 considerada como alta. Así mismo es significativo e importante el instrumento, ya que se logró adaptarlo a nuestro medio local. Es importante precisar que, en nuestra sociedad peruana, los test de evaluación con enfoque clínico son de larga duración solo para medir personalidad, las bondades de este instrumento es que cuenta con 22 ítems normalizados, apropiados a nuestra terminología y que mide los cuadros clínicos basándose en los enfoques teóricos del DSM-IV y DSM-5 (Manuel estadístico de trastornos mentales) y CIE-11 (International Classification of Diseases) res...
3
El cáncer de mama es una de las primeras causas de mortalidad a nivel mundial, la detección temprana esta en relación directa con la disminución de la morbimortalidad, por ello se pone en disyuntiva si se debe realizar el Screening a la población en general o realizar la valoración individual del riesgo. Es importante hacerse una mamografía anual a partir de los 40 años.
4
5
artículo
Publicado 2018
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Introduction. The combined first-trimester screening test is the international recommendation for prenatal screening of trisomy 21. The combined plus screening test adds one or more ultrasound markers (ductus venosus, tricuspid flow, nasal bone). The contingent test is a two-step protocol of risk assessment that considers all markers only as a contingency in the group with an inconclusive result. Objective: Assessment of the performance of the Kagan biochemical contingent protocol in our population. Methods. All pregnant women between 11 and 13 weeks attended in our unit were assessed with the first-trimester combined plus screening test. We followed the Fetal Medicine Foundation published quality criteria and the International Society of Ultrasound in Obstetrics and Gynaecology guidelines. Results 2 578 single pregnancies were assessed; the foetuses were classified by an initial ultraso...
6
tesis de maestría
Publicado 2010
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Menciona que la enfermedad de Chagas, causada por el parásito Trypanosoma cruzi, es endémica de Latinoamérica y afecta entre 16 y 18 millones de personas. Su tratamiento requiere de drogas más efectivas y menos tóxicas. Con el propósito de contar con un método de screening de drogas más sensible y rápido que facilite la selección de compuestos tripanosomicidas candidatos, se planteó como objetivo desarrollar parásitos de T. cruzi que expresen el gen reportero de la luciferasa (luc) de la luciérnaga Photinus pyralis en forma estable. Para la obtención de parásitos luc- transfectantes se construyeron dos plásmidos conteniendo el ORF de luc: el pBS-Neo-Luc y el pR-Luc-Neo. Epimastigotes de la cepa boliviana DH29 fueron electroporados con el DNA circular de estos plásmidos. Los clones fueron obtenidos por diluciones limitantes de los parásitos transfectantes resistentes al ...
7
artículo
Publicado 2015
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There is much expectation on the introduction of prophylactic vaccines against human papilloma virus specifically against 16 and 18 oncogenic type, as theoretically would permit to prevent approximatelly 70% of uterine cervical cancer in the world. The vaccine has been approved in some countries and there is the intention to introduce it in the national programs of immunizations. For example, some states of the United States of North America are considering vaccination obligatory in girls in school age. The objective of this chapter is to determine the effect vaccination would have in uterine cervical cancer screening. For such we need to review the natural history of HPV infection by cervical neoplasia.
8
artículo
Publicado 2015
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There is much expectation on the introduction of prophylactic vaccines against human papilloma virus specifically against 16 and 18 oncogenic type, as theoretically would permit to prevent approximatelly 70% of uterine cervical cancer in the world. The vaccine has been approved in some countries and there is the intention to introduce it in the national programs of immunizations. For example, some states of the United States of North America are considering vaccination obligatory in girls in school age. The objective of this chapter is to determine the effect vaccination would have in uterine cervical cancer screening. For such we need to review the natural history of HPV infection by cervical neoplasia.
9
tesis de maestría
Publicado 2019
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Objetivo General: Evaluar la escala de riesgo FINDRISK como método de screening para insulinoresistencia, prediabetes y diabetes en la en consulta externa en HNAL durante el 2018 Método: Estudio es de tipo descriptivo observacional de corte transversal y prospectivo con muestreo No aleatorizado – Por Conveniencia. Criterios de Inclusión: Paciente de consulta externa del Hospital Nacional Arzobispo Loayza y Paciente mayor de 18 años. Criterios de Exclusión: Mujeres embarazadas, Paciente menor de 18 años. Diagnóstico previo de DM 2, No acepten entrar al estudio (no firma de consentimiento informado) La Población será la atendida en Consulta externa en un año: (411,800 en promedio) La muestra se hallará con un Nivel de confianza= 95% y Margen de error= 5%. Los resultados del test y del laboratorio se reunirán en una base de datos, en el programa Microsoft Excel. Luego se proce...
10
artículo
Publicado 2018
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ABSTRACT Introduction: We are currently experiencing the diabetes pandemic, in 2017 the "International Diabetes Federation" reported that 425 million adults have diabetes. Within the prevention and screening we have FINDRISC (Finnish Diabetes Risk Score), a test that is being widely used, so we must review the available evidence, if it has sufficient predictive capacity to be recommended and used, if there is personalization according to sociodemographic patterns, and if it has relationships. Methods: In this systematic review article, the information was compiled from PubMed, Elsevier library, ScienceDirect, BMJ Journals and “Revista de la facultad de Medicina Humana de la URP. Results: Of 30 articles found, 23 were selected: 12 were analytical, 7 descriptive, 2 cases and control, 2 clinical trials. Conclusion: The average AUC is 77.81%, so it has sufficient positive predictive capaci...
11
artículo
Publicado 2022
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Objective: To identify the factors associated with the interference of gynecological cancer screening in women aged 25-69 years, according to the Demographic and Family Health Survey (ENDES) for the years 2019 and 2020. Materials and methods: Quantitative, observational, analytical cross- sectional study. It was a secondary database analysis obtained by ENDE for the years 2019 and 2020. Generalized linear Poisson family crude and adjusted models were used to estimate the association. The measure of association. The measure of association used was the adjusted prevalence ratio (Rpa) with 95% confidence interval (95% CI). Results: We worked with a total of 18,113 women aged 25-69 who were interviewed at the ENDES 2019-2020. In the descriptive analysis, it is observed that 19.3% did not take a PAP smear (PAP) and 53.6% did not perform “screening for breast cancer”. Women with a pr...
12
artículo
Publicado 2023
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Congenital sensorineural hearing loss is one of the most frequent pathologies of the newborn. To carry out the diagnosis and early detection of this pathology in the pediatric population, specialized audiological tests are required, such as otoacoustic emissions and auditory evoked potentials. Therefore, it is important to have a guide to identify and detect those patients with suspected congenital sensorineural hearing loss.
13
artículo
Publicado 2023
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Congenital sensorineural hearing loss is one of the most frequent pathologies of the newborn. To carry out the diagnosis and early detection of this pathology in the pediatric population, specialized audiological tests are required, such as otoacoustic emissions and auditory evoked potentials. Therefore, it is important to have a guide to identify and detect those patients with suspected congenital sensorineural hearing loss.
14
artículo
Publicado 2015
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Breast cancer is the second most frequent malignant neoplasm in the world and the fifth cause of death from cancer in women. In Peru, breast cancer is second in incidence and the third cause of death from cancer in women. Mammography screening began in 1960 with the goal of detecting cancer at its smallest size before clinically evident in order to have better prognosis and survival. Several trials have been done since to determine mammography importance as a screening method and to establish age to begin, frequency and when to stop screening. In this article the role of mammography as screening tool is reviewed, as well as controversies on use, side effects, and recommendations on its use in Peru.
15
artículo
Publicado 2018
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Currently, ovarian reserve (OR) tests are mainly used in the evaluation of subfertile patients. In this paper, we discuss the use of anti-Müllerian hormone (AMH) levels, which have been associated in some cases with antral follicle count (AFC) and FSH levels in young women, and we propose an algorithm to identify the risk of reduced ovarian reserve. Using her full autonomy and after counseling, the woman would decide whether or not to do the tests, according to her priorities in life. If these tests were altered, the woman could modify her plans in regard to motherhood.
16
tesis de grado
Publicado 2023
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El transportador de resistencia a múltiples medicamentos ACBG2 es una proteína transmembrana que cumple funciones de eliminación de xenobióteicos en una amplia gama de mamíferos. Dado que esta proteína es importante para el desarrollo de resistencia a antineoplásicos y Perú cuenta con diversidad de recursos naturales con potencial actividad terapéutica, el objetivo de nuestro trabajo fue determinar compuestos vegetales oriundos del país con la capacidad de inhibir el transportador ABCG2 por métodos in-silico. Para ello, se usó un pool de 300 compuestos naturales los cuales fueron filtrados a través de un virtual screening en AutoDock tools y Vina, los compuestos de mayor afinidad fueron analizados con PLIP para determinar los residuos de unión y tipo de enlace. Los resultados indican que procyanidin B4 (kd=6.82), procyanidin B5 (Kd=9.58) y rutin (Kd=13.44) mostraron ser com...
17
artículo
Publicado 2024
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Securing access to quality healthcare services, particularly for essential screening tests like mammograms, presents a significant challenge in developing nations. Women often encounter extensive waiting periods, sometimes extending for several months, to undergo a mammogram. This crucial test plays a pivotal role in the early detection of breast cancer, where timely diagnosis is crucial for effective treatment and enhanced survival prospects. Delays in obtaining a diagnosis can significantly impact the health of patients and their well-being, underscoring the importance of early detection. Compounding these challenges is the scarcity of resources and healthcare professionals, which hinders swift and efficient access to preventive care. Such constraints underscore the pressing need for improvements in the interpretation of radiological studies and a reduction in the workload of imaging s...
18
artículo
Publicado 2004
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OBJETIVE: To determine the value of the clock drawing test as a assessment tool for Alzheimer’s disease in elderly patients. MATERIAL AND METHODS: The clock drawing test was applied to patients with and without Alzheimer’s disease attended at the Almenara Hospital Geriatrics Department, Lima Perú. The sample consisted in 31 outpatients (10 males, 21 women) with Alzheimer’s disease and 31 outpatients without this disease (21 males, 10 women). They were requested to draw a clock, using standardized instructions (tenpoint clock drawing test ). Patient with Alzheimer’s disease were graded according to the Hughes’ Clinical Dementia Rating (mild in 10, moderate in 12 and severe in 9). RESULTS: Using a 6-point score as cut off the ten-point clock drawing test had a sensitivity of 83,9%, specificity of 93,5, positive predictive value of 92,9% and negative predictive value 83,5%. CONCL...
19
artículo
Publicado 2018
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ABSTRACT Introduction: We are currently experiencing the diabetes pandemic, in 2017 the "International Diabetes Federation" reported that 425 million adults have diabetes. Within the prevention and screening we have FINDRISC (Finnish Diabetes Risk Score), a test that is being widely used, so we must review the available evidence, if it has sufficient predictive capacity to be recommended and used, if there is personalization according to sociodemographic patterns, and if it has relationships. Methods: In this systematic review article, the information was compiled from PubMed, Elsevier library, ScienceDirect, BMJ Journals and “Revista de la facultad de Medicina Humana de la URP. Results: Of 30 articles found, 23 were selected: 12 were analytical, 7 descriptive, 2 cases and control, 2 clinical trials. Conclusion: The average AUC is 77.81%, so it has sufficient positive predictive capaci...
20
tesis de grado
Publicado 2024
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La investigación se realizó con el objetivo de determinar las propiedades psicométricas del Cuestionario de Salamanca para el screening de trastornos de la personalidad en estudiantes de educación superior matriculados a cuatro escuelas académicas de la Universidad Continental. La investigación se efectuó bajo el enfoque analítico, de tipo descriptiva básico, de diseño no experimental y corte transversal. El muestro fue de tipo probabilístico y estuvo conformado por 1076 estudiantes, se utilizó el Cuestionario Salamanca para el screening de trastornos de la personalidad, versión española 2007. Los resultados evidencian un coeficiente de omega de McDonald de 0.800, el coeficiente de validez de contenido es de 0.887 y en cuanto a la validez de constructo se realizó la prueba de Kaiser-Meyer-Olkin = 0.849, la prueba de esfericidad de Bartlett = 4019.864, sig = 0.000. Y se lle...
