A Functional Assessment Tool to Distinguish Controls From Alzheimer’s Disease in Lima, Peru

• Autores: Custodio, Nilton, Montesinos, Rosa, Chambergo-Michilot, Diego, Herrera-Perez, Eder, Pintado-Caipa, Maritza, Seminario, Wendy, Cuenca, Jose, Mesía, Laura, Failoc-Rojas, Virgilio E, Diaz, Monica M
• Formato: artículo
• Fecha de Publicación: 2022
• Institución: Universidad Privada Norbert Wiener
• Repositorio: UWIENER-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.uwiener.edu.pe:20.500.13053/7019
• Enlace del recurso: https://hdl.handle.net/20.500.13053/7019; https://doi.org/10.1177/15333175221104354
• Nivel de acceso: acceso abierto
• Materia: alzheimer disease, dementia, neurocognitive disorders, peru, validation study; http://purl.org/pe-repo/ocde/ford#3.03.00

Background: The Alzheimer’s Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale is a versatile functional assessment tool for patients with Alzheimer’s disease (AD). We evaluated its performance in controls, Peruvians with MCI or AD. Methods: A cross-sectional study of older adults attending a neurology institute in Lima (Peru) with mild cognitive impairment (MCI), AD or cognitively healthy. Test-retest reliability (intraclass correlation coefficient, ICC; internal consistency, Cronbach’s alpha) and validity were assessed. Results: We enrolled 276 individuals (AD: 113, MCI: 68, controls: 95) with no age, sex, educational level, and depressive symptom differences. Reliability was ideal (ICC: .996), and Cronbach’s alpha was adequate (.937). The ADCS-ADL could not differentiate MCI from controls but did differentiate AD severity. The ADCS-ADL correlated highly with nearly all tools. Conclusions: The ADCS-ADL scale is reliable in a population with AD in Lima, Peru. Future work may validate a tool for Peruvians with lower educational levels.