Incremento de Linfocitos Intraepiteliales en pacientes con Síndrome de Intestino Irritable

• Autores: Arévalo, F., Aragon, V., Montes, P., Guzmán, E., Monge, E.
• Formato: artículo
• Fecha de Publicación: 2014
• Institución: Universidad Peruana de Ciencias Aplicadas
• Repositorio: UPC-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorioacademico.upc.edu.pe:10757/324687
• Enlace del recurso: http://hdl.handle.net/10757/324687
• Nivel de acceso: acceso abierto
• Materia: Sindrome de Intestino Irritable; linfocitos intraepiteliales; Mastocitos,; Células Enterocromafines; Irritable Bowel Syndrome; Intraepithelial Lymphocytes; Mast Cell; Enterochromaffin Cell

Several studies have shown increased numbers of intraepithelial lymphocytes (IEL), mast cells, enterochromaffin cells in colonic mucosa of patients with Irritable Bowel Syndrome (IBS). Many of these findings are based is based on immunohistochemistry results, which is not available in general hospitals. Our objective is to study the histological findings observed in colon biopsies from patients with IBS compared with a group without IBS, using only histochemistry. Twenty five (25) patients were included: 16 with IBS and 9 without IBS. We found increased numbers of IEL in patients with IBS (p=0,002). A group of patients with IBS (41.9%) who fulfilled histological criteria for lymphocytic colitis were excluded. There was no significant difference in mast cells, enterochromaffin cells or eosinophils.