Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials

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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
Detalles Bibliográficos
Autores: Malhotra, Konark, Chang, Jason J., Khunger, Arjun, Blacker, David, Switzer, Jeffrey A., Goyal, Nitin, Hernandez, Adrian V., Pasupuleti, Vinay, Alexandrov, Andrei V., Tsivgoulis, Georgios
Formato: artículo
Fecha de Publicación:2018
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/624615
Enlace del recurso:http://hdl.handle.net/10757/624615
Nivel de acceso:acceso embargado
Materia:Intracerebral hemorrhage
Ischemic stroke
Minocycline
Recovery
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dc.title.en_US.fl_str_mv Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
title Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
spellingShingle Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
Malhotra, Konark
Intracerebral hemorrhage
Ischemic stroke
Minocycline
Recovery
title_short Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
title_full Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
title_fullStr Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
title_full_unstemmed Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
title_sort Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
author Malhotra, Konark
author_facet Malhotra, Konark
Chang, Jason J.
Khunger, Arjun
Blacker, David
Switzer, Jeffrey A.
Goyal, Nitin
Hernandez, Adrian V.
Pasupuleti, Vinay
Alexandrov, Andrei V.
Tsivgoulis, Georgios
author_role author
author2 Chang, Jason J.
Khunger, Arjun
Blacker, David
Switzer, Jeffrey A.
Goyal, Nitin
Hernandez, Adrian V.
Pasupuleti, Vinay
Alexandrov, Andrei V.
Tsivgoulis, Georgios
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.email.es_PE.fl_str_mv konark.malhotra@yahoo.com
dc.contributor.author.fl_str_mv Malhotra, Konark
Chang, Jason J.
Khunger, Arjun
Blacker, David
Switzer, Jeffrey A.
Goyal, Nitin
Hernandez, Adrian V.
Pasupuleti, Vinay
Alexandrov, Andrei V.
Tsivgoulis, Georgios
dc.subject.en_US.fl_str_mv Intracerebral hemorrhage
Ischemic stroke
Minocycline
Recovery
topic Intracerebral hemorrhage
Ischemic stroke
Minocycline
Recovery
description El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
publishDate 2018
dc.date.accessioned.none.fl_str_mv 2018-11-23T15:08:10Z
dc.date.available.none.fl_str_mv 2018-11-23T15:08:10Z
dc.date.issued.fl_str_mv 2018-08
dc.type.en_US.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.issn.none.fl_str_mv 0340-5354
1432-1459
dc.identifier.doi.none.fl_str_mv 10.1007/s00415-018-8935-3
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10757/624615
dc.identifier.journal.en_US.fl_str_mv Journal of Neurology
dc.identifier.isni.none.fl_str_mv 0000 0001 2196 144X
identifier_str_mv 0340-5354
1432-1459
10.1007/s00415-018-8935-3
Journal of Neurology
0000 0001 2196 144X
url http://hdl.handle.net/10757/624615
dc.language.iso.en_US.fl_str_mv eng
language eng
dc.relation.url.en_US.fl_str_mv http://link.springer.com/10.1007/s00415-018-8935-3
dc.rights.en_US.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.en_US.fl_str_mv application/pdf
dc.publisher.en_US.fl_str_mv Dr. Dietrich Steinkopff Verlag GmbH and Co. KG
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Academico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
instname:Universidad Peruana de Ciencias Aplicadas
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dc.source.journaltitle.none.fl_str_mv Journal of Neurology
dc.source.volume.none.fl_str_mv 265
dc.source.issue.none.fl_str_mv 8
dc.source.beginpage.none.fl_str_mv 1871
dc.source.endpage.none.fl_str_mv 1879
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spelling Malhotra, KonarkChang, Jason J.Khunger, ArjunBlacker, DavidSwitzer, Jeffrey A.Goyal, NitinHernandez, Adrian V.Pasupuleti, VinayAlexandrov, Andrei V.Tsivgoulis, Georgioskonark.malhotra@yahoo.com2018-11-23T15:08:10Z2018-11-23T15:08:10Z2018-080340-53541432-145910.1007/s00415-018-8935-3http://hdl.handle.net/10757/624615Journal of Neurology0000 0001 2196 144XEl texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.Background: Various randomized-controlled clinical trials (RCTs) have investigated the neuroprotective role of minocycline in acute ischemic stroke (AIS) or acute intracerebral hemorrhage (ICH) patients. We sought to consolidate and investigate the efficacy and safety of minocycline in patients with acute stroke. Methods: Literature search spanned through November 30, 2017 across major databases to identify all RCTs that reported following efficacy outcomes among acute stroke patients treated with minocycline vs. placebo: National Institute of Health Stroke Scale (NIHSS), Barthel Index (BI), and modified Rankin Scale (mRS) scores. Additional safety, neuroimaging and biochemical endpoints were extracted. We pooled mean differences (MD) and risk ratios (RR) from RCTs using random-effects models. Results: We identified 7 RCTs comprising a total of 426 patients. Of these, additional unpublished data was obtained on contacting corresponding authors of 5 RCTs. In pooled analysis, minocycline demonstrated a favorable trend towards 3-month functional independence (mRS-scores of 0–2) (RR = 1.31; 95% CI 0.98–1.74, p = 0.06) and 3-month BI (MD = 6.92; 95% CI − 0.92, 14.75; p = 0.08). In AIS subgroup, minocycline was associated with higher rates of 3-month mRS-scores of 0–2 (RR = 1.59; 95% CI 1.19–2.12, p = 0.002; I2 = 58%) and 3-month BI (MD = 12.37; 95% CI 5.60, 19.14, p = 0.0003; I2 = 47%), whereas reduced the 3-month NIHSS (MD − 2.84; 95% CI − 5.55, − 0.13; p = 0.04; I2 = 86%). Minocycline administration was not associated with an increased risk of mortality, recurrent stroke, myocardial infarction and hemorrhagic conversion. Conclusions: Although data is limited, minocycline demonstrated efficacy and seems a promising neuroprotective agent in acute stroke patients, especially in AIS subgroup. Further RCTs are needed to evaluate the efficacy and safety of minocycline among ICH patients.Revisión por paresRevisión por paresapplication/pdfengDr. Dietrich Steinkopff Verlag GmbH and Co. 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Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
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