Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation

Descripción del Articulo

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
Detalles Bibliográficos
Autores: Blair, Cheríe S., Lake, Jordan E., Passaro, Ryan C., Chavez-Gomez, Susan, Segura, Eddy R., Elliott, Julie, Fulcher, Jennifer A., Shoptaw, Steven, Cabello, Robinson, Clark, Jesse L.
Formato: artículo
Fecha de Publicación:2021
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/655812
Enlace del recurso:http://hdl.handle.net/10757/655812
Nivel de acceso:acceso embargado
Materia:HIV-1 Seroconversion
Rectal Mucosal Inflammation
Inflammatory cytokines
Secondary analysis
HIV prevention trial
Peru
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oai_identifier_str oai:repositorioacademico.upc.edu.pe:10757/655812
network_acronym_str UUPC
network_name_str UPC-Institucional
repository_id_str 2670
dc.title.en_US.fl_str_mv Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation
title Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation
spellingShingle Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation
Blair, Cheríe S.
HIV-1 Seroconversion
Rectal Mucosal Inflammation
Inflammatory cytokines
Rectal Mucosal Inflammation
Secondary analysis
HIV prevention trial
Peru
title_short Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation
title_full Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation
title_fullStr Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation
title_full_unstemmed Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation
title_sort Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation
author Blair, Cheríe S.
author_facet Blair, Cheríe S.
Lake, Jordan E.
Passaro, Ryan C.
Chavez-Gomez, Susan
Segura, Eddy R.
Elliott, Julie
Fulcher, Jennifer A.
Shoptaw, Steven
Cabello, Robinson
Clark, Jesse L.
author_role author
author2 Lake, Jordan E.
Passaro, Ryan C.
Chavez-Gomez, Susan
Segura, Eddy R.
Elliott, Julie
Fulcher, Jennifer A.
Shoptaw, Steven
Cabello, Robinson
Clark, Jesse L.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Blair, Cheríe S.
Lake, Jordan E.
Passaro, Ryan C.
Chavez-Gomez, Susan
Segura, Eddy R.
Elliott, Julie
Fulcher, Jennifer A.
Shoptaw, Steven
Cabello, Robinson
Clark, Jesse L.
dc.subject.en_US.fl_str_mv HIV-1 Seroconversion
Rectal Mucosal Inflammation
Inflammatory cytokines
Rectal Mucosal Inflammation
Secondary analysis
HIV prevention trial
Peru
topic HIV-1 Seroconversion
Rectal Mucosal Inflammation
Inflammatory cytokines
Rectal Mucosal Inflammation
Secondary analysis
HIV prevention trial
Peru
description El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-05-03T13:48:00Z
dc.date.available.none.fl_str_mv 2021-05-03T13:48:00Z
dc.date.issued.fl_str_mv 2021-04-15
dc.type.en_US.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.doi.none.fl_str_mv 10.1097/QAI.0000000000002601
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10757/655812
dc.identifier.eissn.none.fl_str_mv 19447884
dc.identifier.journal.en_US.fl_str_mv Journal of acquired immune deficiency syndromes (1999)
dc.identifier.eid.none.fl_str_mv 2-s2.0-85102658147
dc.identifier.scopusid.none.fl_str_mv SCOPUS_ID:85102658147
dc.identifier.isni.none.fl_str_mv 0000 0001 2196 144X
identifier_str_mv 10.1097/QAI.0000000000002601
19447884
Journal of acquired immune deficiency syndromes (1999)
2-s2.0-85102658147
SCOPUS_ID:85102658147
0000 0001 2196 144X
url http://hdl.handle.net/10757/655812
dc.language.iso.en_US.fl_str_mv eng
language eng
dc.relation.url.en_US.fl_str_mv https://journals.lww.com/jaids/Abstract/2021/04150/Brief_Report__HIV_1_Seroconversion_Is_Not.10.aspx
dc.rights.en_US.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.en_US.fl_str_mv application/pdf
dc.publisher.en_US.fl_str_mv NLM (Medline)
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Academico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
instname:Universidad Peruana de Ciencias Aplicadas
instacron:UPC
instname_str Universidad Peruana de Ciencias Aplicadas
instacron_str UPC
institution UPC
reponame_str UPC-Institucional
collection UPC-Institucional
dc.source.journaltitle.none.fl_str_mv Journal of acquired immune deficiency syndromes (1999)
dc.source.volume.none.fl_str_mv 86
dc.source.issue.none.fl_str_mv 5
dc.source.beginpage.none.fl_str_mv e134
dc.source.endpage.none.fl_str_mv e138
bitstream.url.fl_str_mv https://repositorioacademico.upc.edu.pe/bitstream/10757/655812/1/license.txt
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
bitstream.checksumAlgorithm.fl_str_mv MD5
repository.name.fl_str_mv Repositorio académico upc
repository.mail.fl_str_mv upc@openrepository.com
_version_ 1846065755613822976
spelling 55606f897eb05ee0b0c81387d32d354b300a8900fa06a9a6c2c6ef1b6ed5101cbb0500765d13512a9f162ab09ac70f9bcd49e8300712b1b0429ead072ec074730f1226ff830097b6f91e6f243a7dbda33e2287b3d171815d7efc9560a49adcb950c8fe21d1cb300ffea4372c31b85008d486d9ecfb5e97c300e366ed29bec307a61cf74fe37be8745f5002d0850184b4a08690f234a6575ba336c500b80401ec17661c723cbcd67869af989aBlair, Cheríe S.Lake, Jordan E.Passaro, Ryan C.Chavez-Gomez, SusanSegura, Eddy R.Elliott, JulieFulcher, Jennifer A.Shoptaw, StevenCabello, RobinsonClark, Jesse L.2021-05-03T13:48:00Z2021-05-03T13:48:00Z2021-04-1510.1097/QAI.0000000000002601http://hdl.handle.net/10757/65581219447884Journal of acquired immune deficiency syndromes (1999)2-s2.0-85102658147SCOPUS_ID:851026581470000 0001 2196 144XEl texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.OBJECTIVE: Determine the impact of HIV-1 seroconversion on inflammatory cytokines in the rectal mucosa. SETTING: Secondary analysis of data from men who have sex with men and transgender women who participated in a HIV prevention trial Lima, Peru. METHODS: From July to December 2017, 605 men who have sex with men and transgender women were screened for rectal gonorrhea/chlamydia (GC/CT). Fifty GC/CT-positive cases were randomly selected and matched with 52 GC/CT-negative controls by age and number of receptive anal intercourse partners in the last month. All participants were HIV-negative at baseline and those with GC/CT at baseline and/or follow-up received appropriate antibiotic therapy. Participants underwent sponge collection of rectal secretions for the measurement of inflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) and were screened for rectal GC/CT and HIV at baseline, 3 months, and 6 months. Wilcoxon rank-sum tests compared inflammatory cytokine levels between participants diagnosed with HIV during follow-up and persons who remained HIV-negative. RESULTS: Eight participants were diagnosed with HIV at the 3-month (n = 6) or 6-month (n = 2) visit. The median number of receptive anal intercourse partners in the month before HIV diagnosis was the same for those who acquired HIV and those who did not. There were no significant differences in inflammatory cytokine levels in rectal mucosa between participants who did and did not experience HIV seroconversion at any time point. CONCLUSIONS: Despite a surge in viral replication during acute infection, findings from this study suggest that there is no prolonged effect of HIV-1 seroconversion on inflammatory cytokine levels in the rectal mucosa. CopyrightNational Institute of Allergy and Infectious DiseasesRevisión por paresapplication/pdfengNLM (Medline)https://journals.lww.com/jaids/Abstract/2021/04150/Brief_Report__HIV_1_Seroconversion_Is_Not.10.aspxinfo:eu-repo/semantics/embargoedAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Academico - UPCJournal of acquired immune deficiency syndromes (1999)865e134e138reponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCHIV-1 SeroconversionRectal Mucosal InflammationInflammatory cytokinesRectal Mucosal InflammationSecondary analysisHIV prevention trialPeruBrief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammationinfo:eu-repo/semantics/articleLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorioacademico.upc.edu.pe/bitstream/10757/655812/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51false10757/655812oai:repositorioacademico.upc.edu.pe:10757/6558122021-05-03 13:48:01.612Repositorio académico upcupc@openrepository.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Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation
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