Sobrevida y características clínico-patológicas de pacientes pediátricos con tumores células germinales de ovario Instituto Nacional de Enfermedades Neoplásicas 2008-2015

• Autor: Chávez Paredes, Sharon Lindsay
• Formato: tesis de maestría
• Fecha de Publicación: 2020
• Institución: Universidad de San Martín de Porres
• Repositorio: USMP-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorio.usmp.edu.pe:20.500.12727/6694
• Enlace del recurso: https://hdl.handle.net/20.500.12727/6694
• Nivel de acceso: acceso abierto
• Materia: Células Germinales embrionarias; Sobrevida; Niño; https://purl.org/pe-repo/ocde/ford#3.02.21

ABSTRACT Objectives: Ovarian germ cell tumors (OGCT) represent about 4.1% of the pediatric neoplasms at the Instituto Nacional De Enfermedades Neoplasicas (INEN). The aim is our study is to determine the Disease-free survival (DFS) and overall survival (OS) in girls with OGCT at the INEN attended between January 2008 and December 2015. Methods: This is a retrospective cohort study. Thirty-three patients with OGCT under 15 years of age were seen in the study period; eight of them were excluded because inclusion criteria were not met. Patients received chemotherapy with bleomycin 15mg/m2 and cisplatin 100mg/m2 on day 1, and etoposide 150 mg/m2 on days 1 to 3. The OS and DFS were evaluated with the Kaplan-Meier method. Results: Between 2008 and 2015, 33 girls have been treated. Mean age was 11 years (range 5 to 14 years). The most frequent symptoms were abdominal pain and tumor in 81% and 85% of cases, respectively. The length of symptoms were between 1 and 12 months. The most common histologic types were mixed and disgerminoma in 42% and 32% respectively. Patients presented in stage I in 12% of cases, stage II in 12%, stage III in 48% and stage IV in 28% of cases. Twelve patients had a relapse and 5 died. Five-year OS was 83% and SLE 60%.In patients with optimal surgery, 5-year DFS was 92.9%; and those with suboptimal surgery 29.1% (p< 0.05). No significant difference was found in the DFS for histologic type, capsular involvement, vascular invasion, lymphatic involvement and stage. Conclusion: Our study shows that most patients with ovarian GCT present in an advanced stage. Suboptimal surgery was a highly significant factor for a worse prognosis in these patients.