Study on inflammation and the nervous system of ethanol extract of jatropha curcas seed

• Autores: Zambrano-Huailla, Alexander, Zambrano-Huailla, Rommel, Goicochea-Lugo, Sergio, Zavala-Flores, Ernesto, García-Berrocal, Jorge, Chau-Saravia, Angel, Pante-Medina, Carlos, Salazar-Granara, Alberto
• Formato: artículo
• Fecha de Publicación: 2016
• Institución: Universidad de San Martín de Porres
• Repositorio: USMP-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.usmp.edu.pe:20.500.12727/6298
• Enlace del recurso: https://hdl.handle.net/20.500.12727/6298; https://doi.org/10.5530/pj.2016.4.5
• Nivel de acceso: acceso abierto
• Materia: Carragenina; Inflamación; Jatropha; Sistema nervioso; Semillas; https://purl.org/pe-repo/ocde/ford#3.02.00

Introduction: Jatropha curcas L. seeds are used in traditional medicine to treat a variety of diseases or conditions. The aim of this study is to evaluate effects on inflammation and the nervous system of ethanol extract of J. curcas seeds. Materials and methods: It was used 64 mice divided in 8 groups; respectively, 4 groups received 400, 600, 800 and 1000 mg/kg of ethanol extract of J. curcas seed; and the rest intake Diclofenac, Diazepam, Caffeine and a control group not received any substance. The effects on inflammation was evaluated by Carrageenan-Induced paw oedema test and by Paw skin temperature. Neurological symptoms of toxicity were evaluated using the Irwin test. For the analysis of quantitative variables were used the following tests: one-way ANOVA, Tukey, Shapiro-Wilk and Pearson correlation; for qualitative variables Chi square was used. Results: According to the paw oedema, it was showed a trend on an inflammatory effect of the seeds of J. curcas; this activity was statistically significant in doses of 1000 mg/kg. Also, the skin temperature measurements outcomes reveal a positive dose response manner. Regard to neurological manifestations, Straub tail was founded in doses of 400 mg/kg. Stereotypies were founded in doses of 400, 600, 800 and 1000 mg/kg throughout the evaluation. Conclusion: J. curcas seeds were showed an inflammatory effect. In addition, effects on the nervous system were founded as stereotypes and Straub tail.