Utilidad de la endoscopia sistemática con bicromoendoscopia para la detección de displasia en pacientes con lesiones premalignas gástricas

• Autores: Yep-Gamarra, Víctor, Díaz-Vélez, Cristian, Araujo, Isis, Ginès, Àngels, Fernández-Esparrach, Gloria
• Formato: artículo
• Fecha de Publicación: 2016
• Institución: Universidad de San Martín de Porres
• Repositorio: USMP-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorio.usmp.edu.pe:20.500.12727/6140
• Enlace del recurso: https://hdl.handle.net/20.500.12727/6140
• Nivel de acceso: acceso abierto
• Materia: Metaplasia; Heridas y traumatismos; Neoplasias gástricas; Tamizaje masivo; https://purl.org/pe-repo/ocde/ford#3.02.00

Abstract Introduction Premalignant gastric lesions have an increased risk to develop gastric cancer. Objective To evaluate the usefulness of systematic endoscopy that includes chromoendoscopy with a double dye staining technique for the detection of dysplasia in patients with premalignant gastric lesions. Patients and methods This longitudinal, prospective study was performed in patients with gastric atrophy, intestinal metaplasia or dysplasia who were referred for endoscopy less than 6 months after the initial diagnosis. The second endoscopy was performed in three phases: phase 1, exhaustive and systematic review of the mucosa with photographic documentation and biopsies of suspicious areas; phase 2, chromoendoscopy with a double dye staining technique using acetic acid 1.2% and indigo carmine 0.5%; phase 3, topographic mapping and random biopsies. Results A total of 50 patients were included. Nine (18%) had atrophic gastritis, 38 (76%) had intestinal metaplasia, and 3 (6%) had low-grade dysplasia. Systematic endoscopy with chromoendoscopy using a double dye staining technique detected more patients with dysplasia (9 versus 3, p < .05), and a larger number of biopsies with the diagnosis of dysplasia were obtained. This occurred for visible (6 vs. 0, p < .05) and non-visible lesions (6 vs. 3, p = NS). In one patient, initial low-grade dysplasia was not detected again in the systematic endoscopy, giving a global endoscopic performance for the detection of lesions of 92%. Conclusions Patients with premalignant gastric lesions have synchronous lesions with greater histological severity, which are detected when systematic endoscopy is conducted with indigo carmine dye added to acetic acid.