Toxicidad aguda y actividad antiinflamatoria del extracto alcohólico e hidroalcohólico de corteza de Spondias mombin L. Y Himatanthus sucuuba

• Autores: Pezo Manuyama, Danilo Junior, Vásquez García, Alex Alejandro
• Formato: tesis de grado
• Fecha de Publicación: 2025
• Institución: Universidad Nacional De La Amazonía Peruana
• Repositorio: UNAPIquitos-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorio.unapiquitos.edu.pe:20.500.12737/11928
• Enlace del recurso: https://hdl.handle.net/20.500.12737/11928
• Nivel de acceso: acceso abierto
• Materia: Toxicidad aguda; Antiinflamatorios; Etánol; Extractos vegetales; Ubos; Spondias mombin; Bellaco caspi; Himatanthus sucuuba; Nauplio (larva); Artemia franciscana; https://purl.org/pe-repo/ocde/ford#3.01.05; https://purl.org/pe-repo/ocde/ford#1.06.03

Throughout history, medicinal plants have been essential for human health care. Various cultures around the world have turned to plants to treat a wide variety of diseases. In this framework, Spondias mombin L. and Himatanthus sucuuba stand out for their notable ethnomedicinal value. Objective: Determine acute toxicity and anti-inflammatory activity of the alcoholic and hydroalcoholic extract of the bark of Spondias mombin L. (ubos) and Himatanthus sucuuba (bellaco caspi). Methodology: The bark was collected for convenience and used to prepare alcoholic and hydroalcoholic extracts. Acute toxicity was evaluated by bioassays in A. franciscana nauplii and anti-inflammatory activity was measured in plasma erythrocytes at concentrations of 10, 100 and 1000 ppm. Results: acute toxicity tests showed an LC50 > 1000 ppm. Regarding anti-inflammatory activity, the alcoholic extract of the bark of S. mombin L. achieved more than 50% inhibition at 1000 ppm, with an IC50 of 971.53 ppm. Conclusion: None of the extracts (alcoholic and hydroalcoholic) showed acute toxicity in A. franciscana nauplii. Only the alcoholic extract of the bark of S. mombin L. presented significant anti-inflammatory activity.