Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines

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The palladium (II) bis-chelate Pd mathematical equation and platinum (II) tetranuclear mathematical equation complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (¿1H, ¿13C) spectroscopy. The complex mathem...

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Detalles Bibliográficos
Autores: Hernández Gorritti, Wilfredo Román, Paz Castillo Berríos, Juan, Vaisberg Wolach, Abraham, Spodine Spiridonova, Evgenia , Richter, Rainer, Beyer, Lothar
Formato: artículo
Fecha de Publicación:2008
Institución:Universidad de Lima
Repositorio:ULIMA-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.ulima.edu.pe:20.500.12724/2408
Enlace del recurso:https://hdl.handle.net/20.500.12724/2408
https://doi.org/10.1155/2008/690952
Nivel de acceso:acceso abierto
Materia:Pendiente
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network_name_str ULIMA-Institucional
repository_id_str 3883
dc.title.en_EN.fl_str_mv Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines
title Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines
spellingShingle Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines
Hernández Gorritti, Wilfredo Román
Pendiente
title_short Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines
title_full Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines
title_fullStr Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines
title_full_unstemmed Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines
title_sort Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines
author Hernández Gorritti, Wilfredo Román
author_facet Hernández Gorritti, Wilfredo Román
Paz Castillo Berríos, Juan
Vaisberg Wolach, Abraham
Spodine Spiridonova, Evgenia 
Richter, Rainer
Beyer, Lothar
author_role author
author2 Paz Castillo Berríos, Juan
Vaisberg Wolach, Abraham
Spodine Spiridonova, Evgenia 
Richter, Rainer
Beyer, Lothar
author2_role author
author
author
author
author
dc.contributor.other.none.fl_str_mv Paz Castillo Berríos, Juan
Hernández Gorritti, Wilfredo Román
dc.contributor.author.fl_str_mv Hernández Gorritti, Wilfredo Román
Paz Castillo Berríos, Juan
Vaisberg Wolach, Abraham
Spodine Spiridonova, Evgenia 
Richter, Rainer
Beyer, Lothar
dc.subject.es_PE.fl_str_mv Pendiente
topic Pendiente
description The palladium (II) bis-chelate Pd mathematical equation and platinum (II) tetranuclear mathematical equation complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (¿1H, ¿13C) spectroscopy. The complex mathematical equation [HL2 = m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a transarrangement, while the complex mathematical equation [HL4 = 4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group. The in vitro antitumor activity of the ligands and their complexes was determined against different human tumor cell lines, which revealed that the palladium (II) and platinum (II) complexes are more cytotoxic than their ligands with IC50 values at the range of 0.07–3.67¿µM. The tetranuclear complex mathematical equation, with the phenyl group in the terminal amine of the ligand, showed higher antiproliferative activity (CI50 = 0.07–0.12¿µM) than the other tested palladium (II) complexes.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.other.none.fl_str_mv Artículo en Scopus
format article
dc.identifier.citation.es_PE.fl_str_mv Hernández, W., Paz, J., Vaisberg, A., Spodine, E., Richter, R., y Beyer, Lothar. (2008). Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines. Bioinorganic Chemistry and Applications, 2008, 9p. doi:10.1155/2008/690952
dc.identifier.issn.none.fl_str_mv 1565-3633
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12724/2408
dc.identifier.journal.none.fl_str_mv Bioinorganic Chemistry and Applications
dc.identifier.eissn.none.fl_str_mv 1687-479X
dc.identifier.isni.none.fl_str_mv 0000000121541816
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1155/2008/690952
dc.identifier.scopusid.none.fl_str_mv 2-s2.0-58149469053
identifier_str_mv Hernández, W., Paz, J., Vaisberg, A., Spodine, E., Richter, R., y Beyer, Lothar. (2008). Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines. Bioinorganic Chemistry and Applications, 2008, 9p. doi:10.1155/2008/690952
1565-3633
Bioinorganic Chemistry and Applications
1687-479X
0000000121541816
2-s2.0-58149469053
url https://hdl.handle.net/20.500.12724/2408
https://doi.org/10.1155/2008/690952
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv urn:issn:1687-479X
dc.rights.*.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/html
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.publisher.country.none.fl_str_mv US
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Repositorio Institucional - Ulima
Universidad de Lima
reponame:ULIMA-Institucional
instname:Universidad de Lima
instacron:ULIMA
instname_str Universidad de Lima
instacron_str ULIMA
institution ULIMA
reponame_str ULIMA-Institucional
collection ULIMA-Institucional
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spelling Hernández Gorritti, Wilfredo RománPaz Castillo Berríos, JuanVaisberg Wolach, AbrahamSpodine Spiridonova, Evgenia Richter, RainerBeyer, LotharPaz Castillo Berríos, JuanHernández Gorritti, Wilfredo Román2008Hernández, W., Paz, J., Vaisberg, A., Spodine, E., Richter, R., y Beyer, Lothar. (2008). Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines. Bioinorganic Chemistry and Applications, 2008, 9p. doi:10.1155/2008/6909521565-3633https://hdl.handle.net/20.500.12724/2408Bioinorganic Chemistry and Applications1687-479X0000000121541816https://doi.org/10.1155/2008/6909522-s2.0-58149469053The palladium (II) bis-chelate Pd mathematical equation and platinum (II) tetranuclear mathematical equation complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (¿1H, ¿13C) spectroscopy. The complex mathematical equation [HL2 = m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a transarrangement, while the complex mathematical equation [HL4 = 4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group. The in vitro antitumor activity of the ligands and their complexes was determined against different human tumor cell lines, which revealed that the palladium (II) and platinum (II) complexes are more cytotoxic than their ligands with IC50 values at the range of 0.07–3.67¿µM. The tetranuclear complex mathematical equation, with the phenyl group in the terminal amine of the ligand, showed higher antiproliferative activity (CI50 = 0.07–0.12¿µM) than the other tested palladium (II) complexes.application/htmlengHindawi Publishing CorporationUSurn:issn:1687-479Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/Repositorio Institucional - UlimaUniversidad de Limareponame:ULIMA-Institucionalinstname:Universidad de Limainstacron:ULIMAPendienteSynthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell linesinfo:eu-repo/semantics/articleArtículo en ScopusOILICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ulima.edu.pe/bitstream/20.500.12724/2408/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5220.500.12724/2408oai:repositorio.ulima.edu.pe:20.500.12724/24082024-11-08 16:16:09.473Repositorio Universidad de Limarepositorio@ulima.edu.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Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines
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