Determination of triclabendazole residues in cow milk from two cattle rearing centers dedicated to the production of dairy products in the department of Cajamarca

• Autores: Huamán, María, Villegas, León, Canales, Marco, Terashima, Angélica
• Formato: artículo
• Fecha de Publicación: 2022
• Institución: Universidad Peruana Cayetano Heredia
• Repositorio: Revistas - Universidad Peruana Cayetano Heredia
• Lenguaje: español
• OAI Identifier: oai:revistas.upch.edu.pe:article/4237
• Enlace del recurso: https://revistas.upch.edu.pe/index.php/STV/article/view/4237
• Nivel de acceso: acceso abierto

The objective was to determine the presence and concentration of triclabendazole (TCBZ) residues in raw cow milk from two cattle rearing centers dedicated to the production of dairy products in Cajamarca, Peru. The Rapid Sedimentation Technique (RST) and Kato-Katz technique were employed to detect and quantify the presence of Fasciola hepatica eggs from stool samples and the detection and quantification of Triclabendazole (TCBZ), triclabendazole Sulfoxide (TCBZSO) and Triclabendazole Sulfone (TCBZSO2) were quantified by High- Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) from milk samples. Fasciola hepatica eggs were found in fecal samples from cows treated with TCBA at one of the centers only. After an approximate withdrawal time of 20 days, TCBZSO and TCBZSO2 were detected in the cow milk at a minimum concentration of 0.006 ug/mL and 0.015 ug/mL, respectively. No TCBZ was found in the same withdrawal time. In this study, both the single dose of TCBZ and the dose based on the breeder’s experience (arbitrary personal judgment) were ineffective for the treatment and control of fasciolosis of the infected cattle. In this sense, the national health authority should establish a withdrawal time and a maximum residue limit to guarantee the safety of dairy products and rule out the likelihood of association with TCBZ resistance in humans.