TSH-secreting pituitary adenoma in a patient with paranoid schizophrenia: case report

• Autores: Valdivieso-Jiménez, Glauco, Paucar-Alfaro, Jimmy, Gonzales-Robles, Linda, Chumpitaz-Álvarez, Verónica, Varela-Roberto, Elizabeth
• Formato: artículo
• Fecha de Publicación: 2025
• Institución: Universidad Peruana Cayetano Heredia
• Repositorio: Revistas - Universidad Peruana Cayetano Heredia
• Lenguaje: español
• OAI Identifier: oai:revistas.upch.edu.pe:article/6330
• Enlace del recurso: https://revistas.upch.edu.pe/index.php/RNP/article/view/6330
• Nivel de acceso: acceso abierto
• Materia: esquizofrenia; microadenoma hipofisiario; ansiedad; tirotropinoma; schizophrenia; TSH-secreting pituitary adenoma; anxiety; thyrotropinoma

The clinical case of a patient with paranoid schizophrenia and persistent anxiety, associated with central hyperthyroidism due to a pituitary microadenoma, is presented. A 24-year-old male with psychotic symptoms and persistent anxiety with somatic symptoms, receiving therapeutic doses of clozapine and benzodiazepines showed clinical improvement after a joint management approach with the endocrinology department due to central hyperthyroidism. Biochemical hormonal analysis and imaging studies were necessary to diagnose a TSH-secreting pituitary microadenoma (thyrotropinoma), a rare medical condition associated in this case with a severe mental disorder. Interdisciplinary management is essential in clinical contexts where diagnostic uncertainty arises, requiring a comprehensive clinical management.