Pancreas Allograft Transplantation in Dogs with Experimental Diabetes Mellitus

• Autores: Mendívil Zapata, Rolando, Garmendia, Fausto, Yerén, Cecilia, Torres, William
• Formato: artículo
• Fecha de Publicación: 1998
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/4518
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4518
• Nivel de acceso: acceso abierto
• Materia: Experimental Diabetes Mellitus; Pancreas Transplant; Diabetes Mellitus Experimental; Transplante de Páncreas

OBJETIVE : To evaluate the efficacy of pancreatic allograft transplantation (TAP ) in dogs with diabetes mellitus ( DME ) induced by alloxan . METHODS : 63 mongrel dogs were used , of which 33 for the very best experimental conditions , the other 30 were divided into 3 groups of 10 each : a) controls, were only produced DME b ) receptors with DME, the who underwent TAP and c) pancreas donors . RESULTS : The glycemic control was complete in 50% of recipients and partial in 30% , giving an overall efficiency of TAP relative to control 80 %. The survival time was 19.9 + TAP post - 6,2 hours. Pathologic examination showed signs of hyperacute rejection , Major complications were gastrointestinal bleeding , aspiration pneumonia , necrotizing pancreatitis with generalized peritonitis , hypoglycemia and dogs not awakened from anesthesia. CONCLUSIONS : The TAP was effective in controlling blood glucose levels in 80 % of animals , but survival was poor, which could be related to the toxic effect of alloxan and hyperacute rejection. More experimental studies are needed to improve survival .