TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS

Descripción del Articulo

Since their therapeutic potential was discovered, stem cells with pluripotent capacity have been sought, and since then embryonic stem cells (ESCs) became an important center in stem cell-basedtherapy, there are ethical problems with the use of embryos. Using a small group of transcription factors (...

Descripción completa

Detalles Bibliográficos
Autores: Aquino Ordinola, Ruth, Tume, Luis
Formato: artículo
Fecha de Publicación:2015
Institución:Universidad Nacional Federico Villarreal
Repositorio:Revistas - Universidad Nacional Federico Villarreal
Lenguaje:español
OAI Identifier:oai:ojs2.revistas.unfv.edu.pe:article/166
Enlace del recurso:https://revistas.unfv.edu.pe/rtb/article/view/166
Nivel de acceso:acceso abierto
Materia:Células madre
epigenética
pluripotencia
factores de transcripción.
epigenetic,
pluripotency
Stem cells
transcription factors
id REVUNFV_4a35344e14dc4fa2825f0c6a4e36412e
oai_identifier_str oai:ojs2.revistas.unfv.edu.pe:article/166
network_acronym_str REVUNFV
network_name_str Revistas - Universidad Nacional Federico Villarreal
repository_id_str .
spelling TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLSFACTORES DE TRANSCRIPCIÓN DE LAS CÉLULAS MADRE EMBRIONARIAS Y CÉLULAS MADRE PLURIPOTENTES INDUCIDASAquino Ordinola, RuthTume, LuisCélulas madreepigenéticapluripotenciafactores de transcripción.epigenetic,pluripotencyStem cellstranscription factorsSince their therapeutic potential was discovered, stem cells with pluripotent capacity have been sought, and since then embryonic stem cells (ESCs) became an important center in stem cell-basedtherapy, there are ethical problems with the use of embryos. Using a small group of transcription factors (c-Myc, Oct4, Klf4 and Sox-2), fibroblasts in pluripotent stem cells (iPSC) were converted. This stem cell technology currently has some disadvantages, because there are differences in gene expression profiles due to retention of an "epigenetic memory" from the cells from which they were derived; this could cause problems when applying them in therapy. In this review we discuss the role of some transcription factors involved in iPSCs and ESCs.En las células madre desde que se descubrió su potencial terapéutico se han buscado células madre con capacidad pluripotente, y desde entonces las células madre embrionarias (ESCs) se convirtieron en un centro importante en la terapia celular basada en células madre, ya que a partir de éstas se forman todos los tejidos del cuerpo, pero involucra problemas éticos por el uso de embriones. Posteriormente al usar un pequeño grupo de factores de transcripción (c-Myc, Oct4, Klf4 y Sox-2) se convirtió fibroblastos en células madre pluripotenciales (iPSC). Esta tecnología de células madre actualmente está teniendo ciertas desventajas, debido a que existen diferencias en los perfiles de expresión génica ya que conservan una “memoria epigenética” de las células donde derivan, lo que podría causar problemas al momento de aplicarlas en terapia. En esta revisión discutimos el papel de algunos factores de transcripción involucrados en las iPSCs y ESCs.Universidad Nacional Federico Villarreal. Facultad de Ciencias Naturales y Matemática. Escuela Profesional de Biología2015-12-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlapplication/epub+ziphttps://revistas.unfv.edu.pe/rtb/article/view/166The Biologist; Vol. 13 No. 1 (2015): The Biologist; 143-152The Biologist; Vol. 13 Núm. 1 (2015): The Biologist (Lima); 143-1521994-90731816-0719reponame:Revistas - Universidad Nacional Federico Villarrealinstname:Universidad Nacional Federico Villarrealinstacron:UNFVspahttps://revistas.unfv.edu.pe/rtb/article/view/166/157https://revistas.unfv.edu.pe/rtb/article/view/166/2220https://revistas.unfv.edu.pe/rtb/article/view/166/2227Derechos de autor 2015 The Biologisthttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessoai:ojs2.revistas.unfv.edu.pe:article/1662022-01-11T23:04:25Z
dc.title.none.fl_str_mv TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS
FACTORES DE TRANSCRIPCIÓN DE LAS CÉLULAS MADRE EMBRIONARIAS Y CÉLULAS MADRE PLURIPOTENTES INDUCIDAS
title TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS
spellingShingle TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS
Aquino Ordinola, Ruth
Células madre
epigenética
pluripotencia
factores de transcripción.
epigenetic,
pluripotency
Stem cells
transcription factors
title_short TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS
title_full TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS
title_fullStr TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS
title_full_unstemmed TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS
title_sort TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS
dc.creator.none.fl_str_mv Aquino Ordinola, Ruth
Tume, Luis
author Aquino Ordinola, Ruth
author_facet Aquino Ordinola, Ruth
Tume, Luis
author_role author
author2 Tume, Luis
author2_role author
dc.subject.none.fl_str_mv Células madre
epigenética
pluripotencia
factores de transcripción.
epigenetic,
pluripotency
Stem cells
transcription factors
topic Células madre
epigenética
pluripotencia
factores de transcripción.
epigenetic,
pluripotency
Stem cells
transcription factors
description Since their therapeutic potential was discovered, stem cells with pluripotent capacity have been sought, and since then embryonic stem cells (ESCs) became an important center in stem cell-basedtherapy, there are ethical problems with the use of embryos. Using a small group of transcription factors (c-Myc, Oct4, Klf4 and Sox-2), fibroblasts in pluripotent stem cells (iPSC) were converted. This stem cell technology currently has some disadvantages, because there are differences in gene expression profiles due to retention of an "epigenetic memory" from the cells from which they were derived; this could cause problems when applying them in therapy. In this review we discuss the role of some transcription factors involved in iPSCs and ESCs.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.unfv.edu.pe/rtb/article/view/166
url https://revistas.unfv.edu.pe/rtb/article/view/166
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistas.unfv.edu.pe/rtb/article/view/166/157
https://revistas.unfv.edu.pe/rtb/article/view/166/2220
https://revistas.unfv.edu.pe/rtb/article/view/166/2227
dc.rights.none.fl_str_mv Derechos de autor 2015 The Biologist
https://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2015 The Biologist
https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
application/epub+zip
dc.publisher.none.fl_str_mv Universidad Nacional Federico Villarreal. Facultad de Ciencias Naturales y Matemática. Escuela Profesional de Biología
publisher.none.fl_str_mv Universidad Nacional Federico Villarreal. Facultad de Ciencias Naturales y Matemática. Escuela Profesional de Biología
dc.source.none.fl_str_mv The Biologist; Vol. 13 No. 1 (2015): The Biologist; 143-152
The Biologist; Vol. 13 Núm. 1 (2015): The Biologist (Lima); 143-152
1994-9073
1816-0719
reponame:Revistas - Universidad Nacional Federico Villarreal
instname:Universidad Nacional Federico Villarreal
instacron:UNFV
instname_str Universidad Nacional Federico Villarreal
instacron_str UNFV
institution UNFV
reponame_str Revistas - Universidad Nacional Federico Villarreal
collection Revistas - Universidad Nacional Federico Villarreal
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1789172150188376064
score 13.959364
TRANSCRIPTION FACTORS OF EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

Ejemplares Similares