SYNTHESIS OF POSSIBLE NICOTINIC AGONISTS WITH POTENTIAL INSECTICIDE ACTIVITY

• Autores: Reyes García, Luis J., Cid, Pia
• Formato: artículo
• Fecha de Publicación: 2016
• Institución: Sociedad Química del Perú
• Repositorio: Revista de la Sociedad Química del Perú
• Lenguaje: español
• OAI Identifier: oai:rsqp.revistas.sqperu.org.pe:article/121
• Enlace del recurso: http://revistas.sqperu.org.pe/index.php/revistasqperu/article/view/121
• Nivel de acceso: acceso abierto
• Materia: Heterocycles synthesis; insecticidal activity; tetrahydropyrimidines; Síntesis heterociclos; actividad insecticida; tetrahidropirimidinas

Ethyl N-benzylpyridine-3-carboximidoate7 was prepared by reacting N-benzylnicotinamide and ethyl chloroformate, the other ethyl imidatehydrochloride, ethyl N-(2-phenylethyl) pyridine-3-carboximidoate8 , was prepared with the same method. Compound6 was obtained by synthesis of N-benzyl-N-(2-cyanoethyl) nicotinamide4 , the latter was used as a starting material to obtain N-(3-aminopropyl)-N-benzylnicotinamide5 by reduction with Ni-Raney in good yield. Cyclization reaction was obtained by p-toluenesulfonic acid of compound5 . Finally, compound (5,6-dihydro-2-(pyridin-3-yl)pyrimidin-1(4H)-yl)(2,4-dimethoxyphenyl) methanone9 was prepared by direct benzoylation of 1,4,5,6-tetrahydro-2-(pyridin-3-yl) pyrimidine.