The coagulation system and COVID-19

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The development of thrombotic complications in COVID-19 appears to be driven by uncontrolled inflammation, and it is clinically different from other conditions such as disseminated intravascular coagulation. The underlying mechanisms seem to be related to endothelial dysfunction and feedback loops b...

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Detalles Bibliográficos
Autor: Rios Pérez, Jorge A.
Formato: artículo
Fecha de Publicación:2021
Institución:Fundación Instituto Hipólito Unanue
Repositorio:Diagnóstico
Lenguaje:español
OAI Identifier:oai:revistadiagnostico.fihu.org.pe:article/254
Enlace del recurso:https://revistadiagnostico.fihu.org.pe/index.php/diagnostico/article/view/254
Nivel de acceso:acceso abierto
Materia:COVID-19
desórdenes de la coagulación
trombosis
blood coagulation disorders
thrombosis
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spelling The coagulation system and COVID-19El sistema de coagulación y COVID-19Rios Pérez, Jorge A. COVID-19desórdenes de la coagulacióntrombosisCOVID-19blood coagulation disordersthrombosisThe development of thrombotic complications in COVID-19 appears to be driven by uncontrolled inflammation, and it is clinically different from other conditions such as disseminated intravascular coagulation. The underlying mechanisms seem to be related to endothelial dysfunction and feedback loops between the immune system and the coagulation system. Thrombosis seems more frequent in critically ill patients with COVID-19. This suggest the need for a different management strategy for COVID-19 associated thrombosis. However, clinical trials are necessary to determine the most adequate approach for COVID-19 associated coagulopathy and thrombotic events.Las anormalidades de la coagulación y el desarrollo de complicaciones trombóticas por COVID-19 parecen estar desencadenadas por una inflamación descontrolada, y ser clínicamente diferentes de otras entidades como la coagulación intravascular diseminada. Los mecanismos subyacentes incluyen la disfunción endotelial e interacciones entre el sistema inmunológico y el de coagulación. Los eventos trombóticos parecen ser más frecuentes en pacientes críticos con COVID-19. Por ende, una estrategia distinta para el manejo de la trombosis asociada a COVID-19 podría ser necesaria. Sin embargo, son necesarios ensayos clínicos para determinar las estrategias más adecuadas en el manejo de los eventos trombóticos asociados a COVID-19.Fundación Instituto Hipólito Unanue2021-02-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistadiagnostico.fihu.org.pe/index.php/diagnostico/article/view/25410.33734/diagnostico.v59i4.254Diagnóstico; Vol. 59 No. 4 (2020); 187-193Diagnostico; Vol. 59 Núm. 4 (2020); 187-1931018-28882709-795110.33734/diagnostico.v59i4reponame:Diagnósticoinstname:Fundación Instituto Hipólito Unanueinstacron:FIHUspahttps://revistadiagnostico.fihu.org.pe/index.php/diagnostico/article/view/254/255Derechos de autor 2021 Jorge A. Rios Pérezinfo:eu-repo/semantics/openAccessoai:revistadiagnostico.fihu.org.pe:article/2542021-06-04T17:51:32Z
dc.title.none.fl_str_mv The coagulation system and COVID-19
El sistema de coagulación y COVID-19
title The coagulation system and COVID-19
spellingShingle The coagulation system and COVID-19
Rios Pérez, Jorge A.
COVID-19
desórdenes de la coagulación
trombosis
COVID-19
blood coagulation disorders
thrombosis
title_short The coagulation system and COVID-19
title_full The coagulation system and COVID-19
title_fullStr The coagulation system and COVID-19
title_full_unstemmed The coagulation system and COVID-19
title_sort The coagulation system and COVID-19
dc.creator.none.fl_str_mv Rios Pérez, Jorge A.
author Rios Pérez, Jorge A.
author_facet Rios Pérez, Jorge A.
author_role author
dc.subject.none.fl_str_mv COVID-19
desórdenes de la coagulación
trombosis
COVID-19
blood coagulation disorders
thrombosis
topic COVID-19
desórdenes de la coagulación
trombosis
COVID-19
blood coagulation disorders
thrombosis
description The development of thrombotic complications in COVID-19 appears to be driven by uncontrolled inflammation, and it is clinically different from other conditions such as disseminated intravascular coagulation. The underlying mechanisms seem to be related to endothelial dysfunction and feedback loops between the immune system and the coagulation system. Thrombosis seems more frequent in critically ill patients with COVID-19. This suggest the need for a different management strategy for COVID-19 associated thrombosis. However, clinical trials are necessary to determine the most adequate approach for COVID-19 associated coagulopathy and thrombotic events.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistadiagnostico.fihu.org.pe/index.php/diagnostico/article/view/254
10.33734/diagnostico.v59i4.254
url https://revistadiagnostico.fihu.org.pe/index.php/diagnostico/article/view/254
identifier_str_mv 10.33734/diagnostico.v59i4.254
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistadiagnostico.fihu.org.pe/index.php/diagnostico/article/view/254/255
dc.rights.none.fl_str_mv Derechos de autor 2021 Jorge A. Rios Pérez
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2021 Jorge A. Rios Pérez
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Fundación Instituto Hipólito Unanue
publisher.none.fl_str_mv Fundación Instituto Hipólito Unanue
dc.source.none.fl_str_mv Diagnóstico; Vol. 59 No. 4 (2020); 187-193
Diagnostico; Vol. 59 Núm. 4 (2020); 187-193
1018-2888
2709-7951
10.33734/diagnostico.v59i4
reponame:Diagnóstico
instname:Fundación Instituto Hipólito Unanue
instacron:FIHU
instname_str Fundación Instituto Hipólito Unanue
instacron_str FIHU
institution FIHU
reponame_str Diagnóstico
collection Diagnóstico
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 12.846861
The coagulation system and COVID-19
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