Antimicrobial resistance in an intensive care unit and current trends: Critical Care Department, IntensiveCare Service of Guillermo Almenara-Irigoyen National Hospital, EsSalud, Lima. Peru, 2004-2006

• Autores: Paz Rojas, Enrique Luis, Ponce de León Pandolfi, Darío, Ramírez Ponce, Rafael
• Formato: artículo
• Fecha de Publicación: 2008
• Institución: Colegio Médico del Perú
• Repositorio: Acta Médica Peruana
• Lenguaje: español
• OAI Identifier: oai:ojs.pkp.sfu.ca:article/1407
• Enlace del recurso: https://amp.cmp.org.pe/index.php/AMP/article/view/1407
• Nivel de acceso: acceso abierto
• Materia: Bacterial resistance

Introduction: This is a description and analysis of the behavior of most frequently isolated microorganisms in the Intensive Care Unit (ICU) of Gullermo Alemnara-Irigoyen Hospital in Lima. Antimicrobial susceptibility/resistance patterns were also analyzed.Material and method: Microorganisms were isolated and their antimicrobial susceptibility patters were assessed using a Micro Scan Walk Away 96 automatic system and Combo NUC panels for determining minimal inhibitory concentrations (MIC) in patients hospitalized in the ICU during the period between 2004 and 2006.Results: Acinetobacter spp. were increasingly isolated, and their resistance to carbapenem antimicrobials rose in a three-year period, from 0% in 2004 to nearly 40% in 2006. Most frequently isolated microorganisms in the respiratory tract were: S. aureus, P. aeruginosa, and Acinetobacter spp.; and S. aureus, Candida spp., and S. epidermidis were the most frequently isolated pathogens in blood cultures. Overall, S. aureus was the most commonly isolated microorganism in the ICU. Oxacillin-resistant S. aureus strains in the ICU had a 93% to 100% frequency in the last year of the study. P. aeruginosa and Acinetobacter spp. have increasing resistance to both traditional and modern antibiotics.Conclusions: The pandemic of antibiotic resistant infections all over the world, and the decline in research and development of new antibacterial compounds may lead us to a somber future, particularly in cases of severe infections, especially in places most affected by antibiotic resistance, such as the ICUs. Since ICU patients have a high rate of infectious complications and considering they are exposed to wide-spectrum antibiotics, this emergence of antibiotic resistance stresses the urgent need for the appropriate use of antimicrobial agents.