La reprogramación en la obtención de células madre pluripotentes inducidas

• Autor: Tume Farfán, Luis Fernando
• Formato: artículo
• Fecha de Publicación: 2018
• Institución: Centro de Preparación para la Ciencia y Tecnología
• Repositorio: ECIPERÚ
• Lenguaje: español
• OAI Identifier: oai:revistas.eciperu.net:article/10
• Enlace del recurso: https://revistas.eciperu.net/index.php/ECIPERU/article/view/10
• Nivel de acceso: acceso abierto
• Materia: Pluripotenciales; factores de transcripción; inducidas; reprogramación; Pluripoten; transcription factors; induced; reprogramming

Because of the ethical problems that have been taking for the use of embryos as a source of pluripotent cells , we have developed new sources for cells with the same characteristics. In this review we discuss some reprogramming methods that have been employed by many researchers around the world , starting with the nuclear transfer and later with the work of Yamanaka who began using the introduction of four transcription factors , Oct3 / 4 , Sox2 , Klf4 and c- Myc that originates successful reprogramming of somatic cells into induced pluripotent stem cells ( iPSC ) , which have genomic and phenotypic characteristics of embryonic stem cells , and discusses some drawbacks with these methods and the risks involve the use of the transcription factor c Myc . Although much room for improvement in this field, iPS cells show a tremendous potential for research and potential therapeutic applications in regenerative medicine.