Association between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women

• Autores: Zavala Valentin, A, Casavilca-Zambrano, S, Navarro-Vásquez, J, Castaneda-Altamirano, CA, Valencia, G, Morante, Z, Calderón, M, Abugattas-Saba, JE, Gómez-Moreno, HL, Fuentes-Rivera, HA, Liendo-Picoaga, R, Cotrina-Concha, JM, Monge, C, Neciosup, SP, Scott, H, Hu, D, Sánchez, SE, Williams, A, Núñez-Marrero, A, Godoy, L, Hechmer, A, Olshen, AB, Dutil, J, Ziv, E, Zabalet,a J, Gelaye B, Vásquez, J, Gálvez-Nino, M, Enriquez-Vera, D, Vidaurre, T, Fejerman, L
• Formato: artículo
• Fecha de Publicación: 2022
• Institución: Instituto Nacional de Enfermedades Neoplásicas
• Repositorio: INEN-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.inen.sld.pe:20.500.14703/259
• Enlace del recurso: https://hdl.handle.net/20.500.14703/259
• Nivel de acceso: acceso abierto
• Materia: Ancestry; Breast Cancer Subtype; Peruvian Women; https://purl.org/pe-repo/ocde/ford#3.02.21

Background: Breast cancer incidence in the United States is lower in Hispanic/Latina (H/L) compared with African American/ Black or Non-Hispanic White women. An Indigenous American breast cancer-protective germline variant (rs140068132) has been reported near the estrogen receptor 1 gene. This study tests the association of rs140068132 and other polymorphisms in the 6q25 region with subtype-specific breast cancer risk in H/Ls of high Indigenous American ancestry. Methods: Genotypes were obtained for 5,094 Peruvian women with (1,755) and without (3,337) breast cancer. Associations between genotype and overall and subtype-specific risk for the protective variant were tested using logistic regression models and conditional analyses, including other risk-associated polymorphisms in the region. Results: We replicated the reported association between rs140068132 and breast cancer risk overall [odds ratio (OR), 0.53