Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

• Autores: Bandyopadhyay, S, Lakhoo, K, Abdelhafeez, H, Wilson, S, Nagras, S, Sheth, M, Gandhi, S, Parwani, D, Raj, R, Munezero, D, Dutta, R, Roseline, NM, McClafferty, K, Nazari, A, Sriram, S, Pillarisetti, S, Nweze, K-D, Ashwinee, A, Kalra, G, Patil, P, Nathani, P, Bhullar, KK, Elhadi, M, Khan, M, Rahim, N, Madhusudanan, S, Erhabor, J, Shirke, M, Mughal, A, Au, D, Salehi, M, Royyuru, S, Ahmed, M, Hussain, SNF, Robinson, D, Casey, A, Dukundane, A, Festus, K, Govind, V, Pancharatnam, R, Ochieng, L, Taylor, EH, Nautiyal, H, De Andres Crespo, M, Charuvila, S, Valetopoulou, A, Zuberi, HK, Bwala, KJ, Umar, AM, Aremu, A, Suleiman, DE, Aliyu, T, Saleem, A, Arshad, M, Turk, K, Altaf, S, Ogunsua, OO, Sholadoye, TT, Tolani, MA, Alfa, Y, Musa, KM, Irungu, EM, Kendirlioglu, BC, Hicdonmez, T, Adhnon, A, Rana, AN, Humad, H, Madasu, A, Azzam, AY, Azab, MA, Ghozy, S, Abbas, AS, Dobs, M, Ghamry, MAM, Alhendy, M, Moses, O, Taibat, IT, Jones, T, Ukoha, K, Goke, O, Ikechukwu, O, Okunlola, AI, Chitnis, M, Nauhaus, H, Erwee, D, Brown, R, Chylinska, A, Simpson, R, Gomes, P, Peter, N, Padilha, MAC, De Oliveira, EP, Junior De Carvalho, LG, Diz, FL, El Kassas, M, Eldaly, U, Tawheed, A, Abdelwahab, M, Yassaad, OM, Hajar, B
• Formato: artículo
• Fecha de Publicación: 2022
• Institución: Instituto Nacional de Enfermedades Neoplásicas
• Repositorio: INEN-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.inen.sld.pe:20.500.14703/269
• Enlace del recurso: https://hdl.handle.net/20.500.14703/269
• Nivel de acceso: acceso abierto
• Materia: Cancer; COVID-19; Health systems; Paediatrics; https://purl.org/pe-repo/ocde/ford#3.02.21

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68)