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artículo

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Publicado por
Bandyopadhyay, S, Lakhoo, K, Abdelhafeez, H, Wilson, S, Nagras, S, Sheth, M, Gandhi, S, Parwani, D, Raj, R, Munezero, D, Dutta, R, Roseline, NM, McClafferty, K, Nazari, A, Sriram, S, Pillarisetti, S, Nweze, K-D, Ashwinee, A, Kalra, G, Patil, P, Nathani, P, Bhullar, KK, Elhadi, M, Khan, M, Rahim, N, Madhusudanan, S, Erhabor, J, Shirke, M, Mughal, A, Au, D, Salehi, M, Royyuru, S, Ahmed, M, Hussain, SNF, Robinson, D, Casey, A, Dukundane, A, Festus, K, Govind, V, Pancharatnam, R, Ochieng, L, Taylor, EH, Nautiyal, H, De Andres Crespo, M, Charuvila, S, Valetopoulou, A, Zuberi, HK, Bwala, KJ, Umar, AM, Aremu, A, Suleiman, DE, Aliyu, T, Saleem, A, Arshad, M, Turk, K, Altaf, S, Ogunsua, OO, Sholadoye, TT, Tolani, MA, Alfa, Y, Musa, KM, Irungu, EM, Kendirlioglu, BC, Hicdonmez, T, Adhnon, A, Rana, AN, Humad, H, Madasu, A, Azzam, AY, Azab, MA, Ghozy, S, Abbas, AS, Dobs, M, Ghamry, MAM, Alhendy, M, Moses, O, Taibat, IT, Jones, T, Ukoha, K, Goke, O, Ikechukwu, O, Okunlola, AI, Chitnis, M, Nauhaus, H, Erwee, D, Brown, R, Chylinska, A, Simpson, R, Gomes, P, Peter, N, Padilha, MAC, De Oliveira, EP, Junior De Carvalho, LG, Diz, FL, El Kassas, M, Eldaly, U, Tawheed, A, Abdelwahab, M, Yassaad, OM, Hajar, B

Publicado 2022

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Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, ...

artículo

Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study

Publicado por
Abdelhafeez, H, Wilson, S, Nagras, S, Sheth, M, Dominic, C, Gandhi, S, Parwani, D, Raj, R, Munezero, D, Dutta, R, Roseline, NM, McClafferty, K, Nazari, A, Sriram, S, Pillarisetti, S, Nweze, KD, Ashwinee, A, Kalra, G, Patil, P, Nathani, P, Bhullar, KK, Elhadi, M, Khan, M, Rahim, N, Madhusudanan, S, Erhabor, J, Shirke, M, Mughal, A, Au, D, Salehi, M, Royyuru, S, Ahmed, M, Hussain, SNF, Robinson, D, Casey, A, Dukundane, A, Festus, K, Govind, V, Pancharatnam, R, Ochieng, L, Taylor, EH, Nautiyal, H, De Andres Crespo, M, Charuvila, S, Valetopoulou, A, Ravi, K, Jalloh, F, Badwi, N, Shah, S, Rajpal, R, Rana, M, Qadir, MA, Uwiringiyimana, E, Fanelli, MCA, Gomes, GMA, Buarque, IL, Guerini IS, Alfurais S, Gamal, M, Hijazi, Y, Tailakh, S, Al-Naggar, H, Douba, Z, Elejla, S, Eldaly, A, Sharashi, E, Mansour, A, Elyan, T, Zazo, A, Bonna, M, Alalami, H, Emam, RY, Alser, M, Abou Chaar, MK, Mazingi, D, Zuberi, HK, Ghosh, DN, Peters NJ, Davies L, Bwala KJ, Umar, AM, Aremu, A, Suleiman, DE, Aliyu, T, Gomes, P, Peter, N, Padilha, MAC, De Oliveira, EP, De Carvalho, LG, Diz, FL, El Kassas, M, Eldaly, U, Tawheed, A, Abdelwahab, M, Yassaad, OM, Hajar, B, Abdessamad EO, Yasser A, Laila H, Yahya, FS

Publicado 2022

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Objectives Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children in high-income countries (HICs). This study aimed to test the hypothesis that the COVID-19 pandemic had affected the delivery of healthcare services worldwide, and exacerbated the disparity in paediatric cancer outcomes between LMICs and HICs. Design A multicentre, international, collaborative cohort study. Setting 91 hospitals and cancer centres in 39 countries providing cancer treatment to paediatric patients between March and December 2020. Participants Patients were included if they were under the age of 18 years, and newly diagnosed with or undergoing active cancer treatment for Acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, Wilms' tumour, sarcoma, retinoblastoma, gliomas...