Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudes

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El Consejo Editorial es un equipo de expertos en el campo de la revista.
Detalles Bibliográficos
Autores: Viruez Soto, Antonio, Arias, Samuel, Casas Mamani, Ronnie, Rada Barrera, Gabriel, Merino Luna, Alfredo, Molano Franco, Daniel, Tinoco Solórzano, Amilcar, Marques, Danuzia A., Zubieta DeUrioste, Natalia, Zubieta Calleja, Gustavo, Arias Reyes, Christian, Soliz, Jorge
Formato: artículo
Fecha de Publicación:2022
Institución:Seguro Social de Salud
Repositorio:ESSALUD-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.essalud.gob.pe:20.500.12959/2787
Enlace del recurso:https://hdl.handle.net/20.500.12959/2787
https://doi.org/10.1016/j.resp.2022.103868
Nivel de acceso:acceso abierto
Materia:Covid-19
Liberal oxygen therapy
Intensive care unit
High-altitude
Central respiration
Normoxemia
Hypoxemia
Hyperoxemia
https://purl.org/pe-repo/ocde/ford#3.02.07
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dc.title.es_PE.fl_str_mv Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudes
title Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudes
spellingShingle Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudes
Viruez Soto, Antonio
Covid-19
Liberal oxygen therapy
Intensive care unit
High-altitude
Central respiration
Normoxemia
Hypoxemia
Hyperoxemia
https://purl.org/pe-repo/ocde/ford#3.02.07
title_short Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudes
title_full Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudes
title_fullStr Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudes
title_full_unstemmed Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudes
title_sort Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudes
author Viruez Soto, Antonio
author_facet Viruez Soto, Antonio
Arias, Samuel
Casas Mamani, Ronnie
Rada Barrera, Gabriel
Merino Luna, Alfredo
Molano Franco, Daniel
Tinoco Solórzano, Amilcar
Marques, Danuzia A.
Zubieta DeUrioste, Natalia
Zubieta Calleja, Gustavo
Arias Reyes, Christian
Soliz, Jorge
author_role author
author2 Arias, Samuel
Casas Mamani, Ronnie
Rada Barrera, Gabriel
Merino Luna, Alfredo
Molano Franco, Daniel
Tinoco Solórzano, Amilcar
Marques, Danuzia A.
Zubieta DeUrioste, Natalia
Zubieta Calleja, Gustavo
Arias Reyes, Christian
Soliz, Jorge
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Viruez Soto, Antonio
Arias, Samuel
Casas Mamani, Ronnie
Rada Barrera, Gabriel
Merino Luna, Alfredo
Molano Franco, Daniel
Tinoco Solórzano, Amilcar
Marques, Danuzia A.
Zubieta DeUrioste, Natalia
Zubieta Calleja, Gustavo
Arias Reyes, Christian
Soliz, Jorge
dc.subject.es_PE.fl_str_mv Covid-19
Liberal oxygen therapy
Intensive care unit
High-altitude
Central respiration
Normoxemia
Hypoxemia
Hyperoxemia
topic Covid-19
Liberal oxygen therapy
Intensive care unit
High-altitude
Central respiration
Normoxemia
Hypoxemia
Hyperoxemia
https://purl.org/pe-repo/ocde/ford#3.02.07
dc.subject.ocde.es_PE.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.02.07
description El Consejo Editorial es un equipo de expertos en el campo de la revista.
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-09-08T21:35:33Z
dc.date.available.none.fl_str_mv 2022-09-08T21:35:33Z
dc.date.issued.fl_str_mv 2022-02-08
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.es_PE.fl_str_mv Respiratory Physiology & Neurobiology. 2022; 299
dc.identifier.issn.none.fl_str_mv 1569-9048
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12959/2787
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.resp.2022.103868
identifier_str_mv Respiratory Physiology & Neurobiology. 2022; 299
1569-9048
url https://hdl.handle.net/20.500.12959/2787
https://doi.org/10.1016/j.resp.2022.103868
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.uri.es_PE.fl_str_mv https://www.sciencedirect.com/science/article/pii/S1569904822000271?via%3Dihub
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.es_PE.fl_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv Consejo Editorial
dc.source.none.fl_str_mv reponame:ESSALUD-Institucional
instname:Seguro Social de Salud
instacron:ESSALUD
instname_str Seguro Social de Salud
instacron_str ESSALUD
institution ESSALUD
reponame_str ESSALUD-Institucional
collection ESSALUD-Institucional
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spelling Viruez Soto, AntonioArias, SamuelCasas Mamani, RonnieRada Barrera, GabrielMerino Luna, AlfredoMolano Franco, DanielTinoco Solórzano, AmilcarMarques, Danuzia A.Zubieta DeUrioste, NataliaZubieta Calleja, GustavoArias Reyes, ChristianSoliz, Jorge2022-09-08T21:35:33Z2022-09-08T21:35:33Z2022-02-08Respiratory Physiology & Neurobiology. 2022; 2991569-9048https://hdl.handle.net/20.500.12959/2787https://doi.org/10.1016/j.resp.2022.103868El Consejo Editorial es un equipo de expertos en el campo de la revista.Patients admitted to the Intensive Care Unit (ICU) with acute hypoxemic respiratory failure automatically receive oxygen therapy to improve inspiratory oxygen fraction (FiO2). Supplemental oxygen is the most prescribed drug for critically ill patients regardless of altitude of residence. In high altitude dwellers (i.e. in La Paz [≈3,400 m] and El Alto [≈4,150 m] in Bolivia), a peripheral oxygen saturation (SatpO2) of 89-95% and an arterial partial pressure of oxygen (PaO2) of 50-67 mmHg (lower as altitude rises), are considered normal values for arterial blood. Consequently, it has been suggested that limiting oxygen therapy to maintain SatpO2 around normoxia may help avoid episodes of hypoxemia, hyperoxemia, intermittent hypoxemia, and ultimately, mortality. In this study, we evaluated the impact of oxygen therapy on the mortality of critically ill COVID-19 patients who permanently live at high altitudes. A multicenter cross-sectional descriptive observational study was performed on 100 patients admitted to the ICU at the “Clinica Los Andes” (in La Paz city) and “Agramont” and “Del Norte” Hospitals (in El Alto city). Our results show that: 1) as expected, fatal cases were detected only in patients who required intubation and connection to invasive mechanical ventilation as a last resort to overcome their life-threatening desaturation; 2) among intubated patients, prolonged periods in normoxia are associated with survival, prolonged periods in hypoxemia are associated with death, and time spent in hyperoxemia shows no association with survival or mortality; 3) the oxygenation limits required to effectively support the intubated patients’ survival in the ICU are between 89% and 93%; 4) among intubated patients with similar periods of normoxemic oxygenation, those with better SOFA scores survive; and 5) a lower frequency of observable reoxygenation events is not associated with survival. In conclusion, our findings indicate that high-altitude patients entering an ICU at altitudes of 3,400 – 4,150 m should undergo oxygen therapy to maintain oxygena- tion levels between 89 and 93 %.application/pdfengConsejo Editorialhttps://www.sciencedirect.com/science/article/pii/S1569904822000271?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/Covid-19Liberal oxygen therapyIntensive care unitHigh-altitudeCentral respirationNormoxemiaHypoxemiaHyperoxemiahttps://purl.org/pe-repo/ocde/ford#3.02.07Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudesinfo:eu-repo/semantics/articlereponame:ESSALUD-Institucionalinstname:Seguro Social de Saludinstacron:ESSALUDORIGINALOxygen therapy limiting peripheral oxygen saturation.pdfOxygen therapy limiting peripheral oxygen saturation.pdfapplication/pdf2659764https://repositorio.essalud.gob.pe/bitstream/20.500.12959/2787/1/Oxygen%20therapy%20limiting%20peripheral%20oxygen%20saturation.pdf1e25bf595ca272a45d285f092bd53d32MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.essalud.gob.pe/bitstream/20.500.12959/2787/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTOxygen therapy limiting peripheral oxygen saturation.pdf.txtOxygen therapy limiting peripheral oxygen saturation.pdf.txtExtracted texttext/plain48790https://repositorio.essalud.gob.pe/bitstream/20.500.12959/2787/3/Oxygen%20therapy%20limiting%20peripheral%20oxygen%20saturation.pdf.txt896450b33245df50c0bcdd73f68e7dccMD53THUMBNAILOxygen therapy limiting peripheral oxygen saturation.pdf.jpgOxygen therapy limiting peripheral oxygen saturation.pdf.jpgGenerated Thumbnailimage/jpeg7081https://repositorio.essalud.gob.pe/bitstream/20.500.12959/2787/4/Oxygen%20therapy%20limiting%20peripheral%20oxygen%20saturation.pdf.jpg983b2849097858944a7ff1d9411d15feMD5420.500.12959/2787oai:repositorio.essalud.gob.pe:20.500.12959/27872023-07-20 10:56:51.775Repositorio Seguro Social de Salud – ESSALUDbibliotecacentral@essalud.gob.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Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill Covid-19 patients at high altitudes
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