A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.

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El Consejo Editorial es un equipo de expertos en el campo de la revista.
Detalles Bibliográficos
Autores: Rodriguez, Lourdes, Bustamante, Beatriz, Huaroto, Luz, Agurto, Cecilia, Illescas, Ricardo, Ramirez, Rafael, Díaz, Alberto, Hidalgo, José
Formato: artículo
Fecha de Publicación:2017
Institución:Seguro Social de Salud
Repositorio:ESSALUD-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.essalud.gob.pe:20.500.12959/546
Enlace del recurso:https://hdl.handle.net/20.500.12959/546
https://doi.org/10.1371/journal.pone.0175172
Nivel de acceso:acceso abierto
Materia:Medicina General e Interna
Candidemia
Infecciones Bacterianas y Micosis
https://purl.org/pe-repo/ocde/ford#3.02.19
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dc.title.es_PE.fl_str_mv A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.
title A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.
spellingShingle A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.
Rodriguez, Lourdes
Medicina General e Interna
Candidemia
Infecciones Bacterianas y Micosis
https://purl.org/pe-repo/ocde/ford#3.02.19
title_short A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.
title_full A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.
title_fullStr A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.
title_full_unstemmed A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.
title_sort A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.
author Rodriguez, Lourdes
author_facet Rodriguez, Lourdes
Bustamante, Beatriz
Huaroto, Luz
Agurto, Cecilia
Illescas, Ricardo
Ramirez, Rafael
Díaz, Alberto
Hidalgo, José
author_role author
author2 Bustamante, Beatriz
Huaroto, Luz
Agurto, Cecilia
Illescas, Ricardo
Ramirez, Rafael
Díaz, Alberto
Hidalgo, José
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodriguez, Lourdes
Bustamante, Beatriz
Huaroto, Luz
Agurto, Cecilia
Illescas, Ricardo
Ramirez, Rafael
Díaz, Alberto
Hidalgo, José
dc.subject.es_PE.fl_str_mv Medicina General e Interna
Candidemia
Infecciones Bacterianas y Micosis
topic Medicina General e Interna
Candidemia
Infecciones Bacterianas y Micosis
https://purl.org/pe-repo/ocde/ford#3.02.19
dc.subject.ocde.es_PE.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.02.19
description El Consejo Editorial es un equipo de expertos en el campo de la revista.
publishDate 2017
dc.date.accessioned.none.fl_str_mv 2019-05-16T22:47:01Z
dc.date.available.none.fl_str_mv 2019-05-16T22:47:01Z
dc.date.issued.fl_str_mv 2017-04
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dc.identifier.citation.es_PE.fl_str_mv Plos One. 2017; 12(4).
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12959/546
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1371/journal.pone.0175172
identifier_str_mv Plos One. 2017; 12(4).
1932-6203
url https://hdl.handle.net/20.500.12959/546
https://doi.org/10.1371/journal.pone.0175172
dc.language.iso.es_PE.fl_str_mv eng
language eng
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dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv Editorial Board
dc.publisher.country.es_PE.fl_str_mv PE
dc.source.es_PE.fl_str_mv Seguro Social de Salud (EsSalud)
Repositorio Institucional EsSalud
dc.source.none.fl_str_mv reponame:ESSALUD-Institucional
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spelling Rodriguez, LourdesBustamante, BeatrizHuaroto, LuzAgurto, CeciliaIllescas, RicardoRamirez, RafaelDíaz, AlbertoHidalgo, José2019-05-16T22:47:01Z2019-05-16T22:47:01Z2017-04Plos One. 2017; 12(4).1932-6203https://hdl.handle.net/20.500.12959/546https://doi.org/10.1371/journal.pone.0175172El Consejo Editorial es un equipo de expertos en el campo de la revista.La incidencia de candidemia está incrementada en países en desarrollo. Muy poco es conocido sobre la epidemiología de la candidemia en Perú. El objetivo de este estudio es describir la incidencia, microbiología, presentación clínica y el desenlace de las infecciones del torrente sanguíneo por cándida, en los hospitales Guillermo Almenara Irigoyen, Dos de Mayo y Alberto Sabogal, entre noviembre 2013 y enero 2015. La información fue obtenida de las historias clínicas y evaluada. Se encontró una proporción muy alta de especies de Candida no albicans, a pesar de esto, la disminuída susceptibilidad/resistencia al fluconazol fue sólo del 13.3% y no se observó en otros tratamientos antifungicos. Sin embargo, la incidencia de mortalidad por candidemia fue alta comparada con otros estudios internacionales. Es posible que el retrazo en el inicio del tratmiento antifúngico contribuyera al alto nivel de mortalidad a pesar de la baja resistencia antifúngica.The incidence of candidemia is increasing in developing countries. Very little is known about the epidemiology of candidemia in Peru. The aim of this study is to describe the incidence, microbiology, clinical presentation and outcomes of Candida bloodstream infections in three Lima-Callao hospitals. Methods: Candida spp. isolates were identified prospectively at participant hospitals between November 2013 and January 2015. Susceptibility testing for amphotericin B, fluconazole, posaconazole, voriconazole and anidulafungin was performed using broth microdilution method. Clinical information was obtained from medical records and evaluated. Results: We collected information on 158 isolates and 157 patients. Median age of patients was 55.0 yrs., and 64.1% were males. Thirty-eight (24.2%) episodes of candidemia occurred in those <18 yrs. The frequency of non-Candida albicans was 72.1%. The most frequently recovered species were C. albicans (n = 44, 27.8%), C. parapsilosis (n = 40, 25.3%), C. tropicalis (n = 39, 24.7%) and C. glabrata (n = 15, 9.5%). Only four isolates were resistant to fluconazole, 86.7% (n = 137) were susceptible and 17 were susceptible-dose dependent. Decreased susceptibility to posaconazole was also observed in three isolates, and one to voriconazole. All isolates were susceptible to anidulafungin and amphotericin B. The most commonly associated co-morbid conditions were recent surgery (n = 61, 38.9%), mechanical ventilation (n = 60, 38.2%) and total parenteral nutrition (n = 57, 36.3%). The incidence of candidemia by center ranged between 1.01 and 2.63 cases per 1,000 admissions, with a global incidence of 2.04. Only 28.1% of cases received treatment within 72 hrs. of diagnosis. Overall, the 30-day survival was 60.4% (treated subjects, 67.4%; not-treated patients, 50.9%). Conclusions: We found a very high proportion of non-albicans Candida species. Despite this, the decreased susceptibility/resistance to fluconazole was only 13.3% and not seen in the other antifungals. Overall, the incidence of candidemia mortality was high when compared to other international studies. It is possible, that the delay in initiating antifungal treatment contributed to the elevated mortality rate, in spite of low antifungal resistance.application/pdfengEditorial BoardPEhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175172info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/Seguro Social de Salud (EsSalud)Repositorio Institucional EsSaludreponame:ESSALUD-Institucionalinstname:Seguro Social de Saludinstacron:ESSALUDMedicina General e InternaCandidemiaInfecciones Bacterianas y Micosishttps://purl.org/pe-repo/ocde/ford#3.02.19A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.info:eu-repo/semantics/articleORIGINALA multi-centric study of Candida bloodstream infection in Lima-Callao, Peru.pdfA multi-centric study of Candida bloodstream infection in Lima-Callao, Peru.pdfapplication/pdf1296085https://repositorio.essalud.gob.pe/bitstream/20.500.12959/546/1/A%20multi-centric%20study%20of%20Candida%20bloodstream%20infection%20in%20Lima-Callao%2c%20Peru.pdf1535925ab3d24ec58dd9c72b7a0597b0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.essalud.gob.pe/bitstream/20.500.12959/546/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTA multi-centric study of Candida bloodstream infection in Lima-Callao, Peru.pdf.txtA multi-centric study of Candida bloodstream infection in Lima-Callao, Peru.pdf.txtExtracted texttext/plain42388https://repositorio.essalud.gob.pe/bitstream/20.500.12959/546/3/A%20multi-centric%20study%20of%20Candida%20bloodstream%20infection%20in%20Lima-Callao%2c%20Peru.pdf.txt10969e1f5d747247ba0cf0d921b71174MD53THUMBNAILA multi-centric study of Candida bloodstream infection in Lima-Callao, Peru.pdf.jpgA multi-centric study of Candida bloodstream infection in Lima-Callao, Peru.pdf.jpgGenerated Thumbnailimage/jpeg6913https://repositorio.essalud.gob.pe/bitstream/20.500.12959/546/4/A%20multi-centric%20study%20of%20Candida%20bloodstream%20infection%20in%20Lima-Callao%2c%20Peru.pdf.jpg4332c8b1dda4b1e78028aacd05b2ce39MD5420.500.12959/546oai:repositorio.essalud.gob.pe:20.500.12959/5462023-07-31 09:53:03.502Repositorio Seguro Social de Salud – ESSALUDbibliotecacentral@essalud.gob.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A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes.
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