Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples

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This project was supported by FONDECYT-BM (grant #0232019-FONDECYT-BM-IN.INV), FAPESP (grants #2019/006777 and #2014/50945-4), CNPq (grants #301728/2019-4, #408050/2018-7 and #465571/2014-0), and CAPES (PROJ. AUX/PE/PROEX N. 0674/2018). RL and GP received financial support from the OGI, Research Man...

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Autores: Lopez, Rosario, Khan, Sabir, Wong, Ademar, Sotomayor, Maria del Pilar Taboada, Picasso, Gino
Formato: artículo
Fecha de Publicación:2021
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/2927
Enlace del recurso:https://hdl.handle.net/20.500.12390/2927
https://doi.org/10.3389/fchem.2021.615602
Nivel de acceso:acceso abierto
Materia:selective adsorption
mag-MIP
amoxicillin
electrochemical sensor
carbon paste electrode
https://purl.org/pe-repo/ocde/ford#2.02.02
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oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/2927
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
title Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
spellingShingle Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
Lopez, Rosario
selective adsorption
mag-MIP
amoxicillin
electrochemical sensor
carbon paste electrode
https://purl.org/pe-repo/ocde/ford#2.02.02
title_short Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
title_full Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
title_fullStr Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
title_full_unstemmed Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
title_sort Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
author Lopez, Rosario
author_facet Lopez, Rosario
Khan, Sabir
Wong, Ademar
Sotomayor, Maria del Pilar Taboada
Picasso, Gino
author_role author
author2 Khan, Sabir
Wong, Ademar
Sotomayor, Maria del Pilar Taboada
Picasso, Gino
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lopez, Rosario
Khan, Sabir
Wong, Ademar
Sotomayor, Maria del Pilar Taboada
Picasso, Gino
dc.subject.none.fl_str_mv selective adsorption
topic selective adsorption
mag-MIP
amoxicillin
electrochemical sensor
carbon paste electrode
https://purl.org/pe-repo/ocde/ford#2.02.02
dc.subject.es_PE.fl_str_mv mag-MIP
amoxicillin
electrochemical sensor
carbon paste electrode
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#2.02.02
description This project was supported by FONDECYT-BM (grant #0232019-FONDECYT-BM-IN.INV), FAPESP (grants #2019/006777 and #2014/50945-4), CNPq (grants #301728/2019-4, #408050/2018-7 and #465571/2014-0), and CAPES (PROJ. AUX/PE/PROEX N. 0674/2018). RL and GP received financial support from the OGI, Research Management Bureau (Project FC-F-6-2018).
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/2927
dc.identifier.doi.none.fl_str_mv https://doi.org/10.3389/fchem.2021.615602
url https://hdl.handle.net/20.500.12390/2927
https://doi.org/10.3389/fchem.2021.615602
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv FRONTIERS IN CHEMISTRY
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
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spelling Publicationrp08177600rp08176600rp08180600rp08179600rp08178600Lopez, RosarioKhan, SabirWong, AdemarSotomayor, Maria del Pilar TaboadaPicasso, Gino2024-05-30T23:13:38Z2024-05-30T23:13:38Z2021https://hdl.handle.net/20.500.12390/2927https://doi.org/10.3389/fchem.2021.615602This project was supported by FONDECYT-BM (grant #0232019-FONDECYT-BM-IN.INV), FAPESP (grants #2019/006777 and #2014/50945-4), CNPq (grants #301728/2019-4, #408050/2018-7 and #465571/2014-0), and CAPES (PROJ. AUX/PE/PROEX N. 0674/2018). RL and GP received financial support from the OGI, Research Management Bureau (Project FC-F-6-2018).This work describes an electrochemical sensor for the selective recognition and quantification of amoxicillin and a beta-lactam antibiotic in real samples. This sensor consists of a carbon paste electrode (CPE) modified with mag-MIP (magnetic molecularly imprinted polymer), which was prepared by precipitation method via free radical using acrylamide (AAm) as functional monomer, N,N '-methylenebisacrylamide (MBAA) as a crosslinker, and potassium persulfate (KPS) as initiator, to functionalized magnetic nanoparticles. The magnetic non-imprinted polymers (mag-NIP) were prepared using the same experimental procedure without analyte and used for the preparation of a CPE for comparative studies. The morphological, structural, and electrochemical characteristics of the nanostructured material were evaluated using Field emission gun scanning electron microscopy (FEG-SEM), Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Vibrating sample magnetometry (VSM), X-ray diffraction (XRD), and voltammetric technique. Electrochemical experiments performed by square wave voltammetry show that the mag-MIP/CPE sensor had a better signal response compared to the non-imprinted polymer-modified electrode (mag-NIP/CPE). The sensor showed a linear range from 2.5 to 57 mu mol L-1 of amoxicillin (r(2) = 0.9964), with a limit of detection and a limit of quantification of 0.75 and 2.48 mu mol L-1, respectively. No significant interference in the electrochemical signal of amoxicillin was observed during the testing experiments in real samples (skimmed milk and river water). The proposed mag-MIP/CPE sensor could be used as a good alternative method to confront other techniques to determine amoxicillin in different samples.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengFrontiers Media SAFRONTIERS IN CHEMISTRYinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/selective adsorptionmag-MIP-1amoxicillin-1electrochemical sensor-1carbon paste electrode-1https://purl.org/pe-repo/ocde/ford#2.02.02-1Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samplesinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/2927oai:repositorio.concytec.gob.pe:20.500.12390/29272024-05-30 16:12:13.581https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="65cadfbe-5ab9-47e8-8db9-e30b2277fd2e"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples</Title> <PublishedIn> <Publication> <Title>FRONTIERS IN CHEMISTRY</Title> </Publication> </PublishedIn> <PublicationDate>2021</PublicationDate> <DOI>https://doi.org/10.3389/fchem.2021.615602</DOI> <Authors> <Author> <DisplayName>Lopez, Rosario</DisplayName> <Person id="rp08177" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Khan, Sabir</DisplayName> <Person id="rp08176" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Wong, Ademar</DisplayName> <Person id="rp08180" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Sotomayor, Maria del Pilar Taboada</DisplayName> <Person id="rp08179" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Picasso, Gino</DisplayName> <Person id="rp08178" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Frontiers Media SA</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by-nc-nd/4.0/</License> <Keyword>selective adsorption</Keyword> <Keyword>mag-MIP</Keyword> <Keyword>amoxicillin</Keyword> <Keyword>electrochemical sensor</Keyword> <Keyword>carbon paste electrode</Keyword> <Abstract>This work describes an electrochemical sensor for the selective recognition and quantification of amoxicillin and a beta-lactam antibiotic in real samples. This sensor consists of a carbon paste electrode (CPE) modified with mag-MIP (magnetic molecularly imprinted polymer), which was prepared by precipitation method via free radical using acrylamide (AAm) as functional monomer, N,N &apos;-methylenebisacrylamide (MBAA) as a crosslinker, and potassium persulfate (KPS) as initiator, to functionalized magnetic nanoparticles. The magnetic non-imprinted polymers (mag-NIP) were prepared using the same experimental procedure without analyte and used for the preparation of a CPE for comparative studies. The morphological, structural, and electrochemical characteristics of the nanostructured material were evaluated using Field emission gun scanning electron microscopy (FEG-SEM), Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Vibrating sample magnetometry (VSM), X-ray diffraction (XRD), and voltammetric technique. Electrochemical experiments performed by square wave voltammetry show that the mag-MIP/CPE sensor had a better signal response compared to the non-imprinted polymer-modified electrode (mag-NIP/CPE). The sensor showed a linear range from 2.5 to 57 mu mol L-1 of amoxicillin (r(2) = 0.9964), with a limit of detection and a limit of quantification of 0.75 and 2.48 mu mol L-1, respectively. No significant interference in the electrochemical signal of amoxicillin was observed during the testing experiments in real samples (skimmed milk and river water). The proposed mag-MIP/CPE sensor could be used as a good alternative method to confront other techniques to determine amoxicillin in different samples.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.439043
Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
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