SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional study
Descripción del Articulo
This study was supported by FONDECYT (Fondo Nacional de Ciencia y Tecnología, Peru), code: 071-2020. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
| Autores: | , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2021 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/3052 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/3052 https://doi.org/10.7717/peerj.12149 |
| Nivel de acceso: | acceso abierto |
| Materia: | Seroprevalence Altitude COVID Peru https://purl.org/pe-repo/ocde/ford#3.03.08 |
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SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional study |
| title |
SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional study |
| spellingShingle |
SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional study Huamaní C. Seroprevalence Altitude Altitude COVID Peru https://purl.org/pe-repo/ocde/ford#3.03.08 |
| title_short |
SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional study |
| title_full |
SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional study |
| title_fullStr |
SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional study |
| title_full_unstemmed |
SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional study |
| title_sort |
SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional study |
| author |
Huamaní C. |
| author_facet |
Huamaní C. Velásquez L. Montes S. Mayanga-Herrera A. Bernabé-Ortiz A. |
| author_role |
author |
| author2 |
Velásquez L. Montes S. Mayanga-Herrera A. Bernabé-Ortiz A. |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Huamaní C. Velásquez L. Montes S. Mayanga-Herrera A. Bernabé-Ortiz A. |
| dc.subject.none.fl_str_mv |
Seroprevalence |
| topic |
Seroprevalence Altitude Altitude COVID Peru https://purl.org/pe-repo/ocde/ford#3.03.08 |
| dc.subject.es_PE.fl_str_mv |
Altitude Altitude COVID Peru |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.03.08 |
| description |
This study was supported by FONDECYT (Fondo Nacional de Ciencia y Tecnología, Peru), code: 071-2020. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2021 |
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info:eu-repo/semantics/article |
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article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/3052 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.7717/peerj.12149 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85115293048 |
| url |
https://hdl.handle.net/20.500.12390/3052 https://doi.org/10.7717/peerj.12149 |
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2-s2.0-85115293048 |
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eng |
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eng |
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PeerJ |
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info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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PeerJ Inc. |
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PeerJ Inc. |
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reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
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CONCYTEC-Institucional |
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Repositorio Institucional CONCYTEC |
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repositorio@concytec.gob.pe |
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1844883129045614592 |
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Publicationrp08753600rp08751600rp08750600rp08752600rp05799600Huamaní C.Velásquez L.Montes S.Mayanga-Herrera A.Bernabé-Ortiz A.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2021https://hdl.handle.net/20.500.12390/3052https://doi.org/10.7717/peerj.121492-s2.0-85115293048This study was supported by FONDECYT (Fondo Nacional de Ciencia y Tecnología, Peru), code: 071-2020. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Background. There are several ecological studies, but few studies of the prevalence of SARS-COV-2 at high altitude. We aimed to estimate the population-based seroprevalence of SARS-COV-2 in three settings of Cusco at the end of the first wave among adults. Methods. A population-based survey was conducted in September 2020, in three settings in the region of Cusco: (1) Cusco city at 3,300 meters above the sea level (m.a.s.l.), (2) the periphery of Cusco (Santiago, San Jerónimo, San Sebastián, and Wanchaq) at 3,300 m.a.s.l., and (3) Quillabamba city, located at 1,050 m.a.s.l. People aged ? 18 years within a family unit were included. The diagnosis of SARS-CoV-2 infection was based on identifying anti- SARS-CoV-2 total antibodies (IgM and IgG) in serum using the Elecsys Anti-SARS-CoV-2 chemiluminescence test. Results. We enrolled 1924 participants from 712 families. Of the total, 637 participants were anti-SARS-CoV-2 seropositive. Seroprevalence was 38.8% (95% CI [33.4%-44.9%]) in Cusco city, 34.9% (95% CI [30.4%-40.1%]) in the periphery of Cusco, and 20.3% (95% CI [16.2%-25.6%]) in Quillabamba. In 141 families (19.8%; 95% CI [17.0%-22.8%]) the whole members were positive to the test. Living with more than three persons in the same house, a positive COVID-19 case at home, and a member who died in the last five months were factors associated with SARS-COV-2 seropositivity. Dysgeusia/dysosmia was the symptom most associated with seropositivity (aPR = 2.74, 95% CI [2.41-3.12]); whereas always wearing a face shield (aPR = 0. 73; 95% CI [0.60-0.89]) or a facial mask (aPR = 0.76, 95% CI [0.63-0. 92) reduced that probability. Conclusions. A great proportion of Cusco's city inhabitants presented anti-SARS-CoV-2 antibodies at the end of the first wave, with significant differences between settings. Wearing masks and face shields were associated with lower rate of seropositivity; however, efforts must be made to sustain them over time since there is still a high proportion of susceptible people. © 2021 PeerJ Inc.. All rights reserved.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengPeerJ Inc.PeerJinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/SeroprevalenceAltitude-1Altitude-1COVID-1Peru-1https://purl.org/pe-repo/ocde/ford#3.03.08-1SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional studyinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/3052oai:repositorio.concytec.gob.pe:20.500.12390/30522024-05-30 16:13:32.175https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="f3e4dae7-71f2-4e68-b453-b003a40398eb"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>SARS-CoV-2 seroprevalence in a high-altitude setting in Peru: Adult population-based cross-sectional study</Title> <PublishedIn> <Publication> <Title>PeerJ</Title> </Publication> </PublishedIn> <PublicationDate>2021</PublicationDate> <DOI>https://doi.org/10.7717/peerj.12149</DOI> <SCP-Number>2-s2.0-85115293048</SCP-Number> <Authors> <Author> <DisplayName>Huamaní C.</DisplayName> <Person id="rp08753" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Velásquez L.</DisplayName> <Person id="rp08751" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Montes S.</DisplayName> <Person id="rp08750" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Mayanga-Herrera A.</DisplayName> <Person id="rp08752" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Bernabé-Ortiz A.</DisplayName> <Person id="rp05799" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>PeerJ Inc.</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by-nc-nd/4.0/</License> <Keyword>Seroprevalence</Keyword> <Keyword>Altitude</Keyword> <Keyword>Altitude</Keyword> <Keyword>COVID</Keyword> <Keyword>Peru</Keyword> <Abstract>Background. There are several ecological studies, but few studies of the prevalence of SARS-COV-2 at high altitude. We aimed to estimate the population-based seroprevalence of SARS-COV-2 in three settings of Cusco at the end of the first wave among adults. Methods. A population-based survey was conducted in September 2020, in three settings in the region of Cusco: (1) Cusco city at 3,300 meters above the sea level (m.a.s.l.), (2) the periphery of Cusco (Santiago, San Jerónimo, San Sebastián, and Wanchaq) at 3,300 m.a.s.l., and (3) Quillabamba city, located at 1,050 m.a.s.l. People aged ? 18 years within a family unit were included. The diagnosis of SARS-CoV-2 infection was based on identifying anti- SARS-CoV-2 total antibodies (IgM and IgG) in serum using the Elecsys Anti-SARS-CoV-2 chemiluminescence test. Results. We enrolled 1924 participants from 712 families. Of the total, 637 participants were anti-SARS-CoV-2 seropositive. Seroprevalence was 38.8% (95% CI [33.4%-44.9%]) in Cusco city, 34.9% (95% CI [30.4%-40.1%]) in the periphery of Cusco, and 20.3% (95% CI [16.2%-25.6%]) in Quillabamba. In 141 families (19.8%; 95% CI [17.0%-22.8%]) the whole members were positive to the test. Living with more than three persons in the same house, a positive COVID-19 case at home, and a member who died in the last five months were factors associated with SARS-COV-2 seropositivity. Dysgeusia/dysosmia was the symptom most associated with seropositivity (aPR = 2.74, 95% CI [2.41-3.12]); whereas always wearing a face shield (aPR = 0. 73; 95% CI [0.60-0.89]) or a facial mask (aPR = 0.76, 95% CI [0.63-0. 92) reduced that probability. Conclusions. A great proportion of Cusco's city inhabitants presented anti-SARS-CoV-2 antibodies at the end of the first wave, with significant differences between settings. Wearing masks and face shields were associated with lower rate of seropositivity; however, efforts must be made to sustain them over time since there is still a high proportion of susceptible people. © 2021 PeerJ Inc.. All rights reserved.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.377223 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
