Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital
Descripción del Articulo
JR was supported by Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT - Perú) within the “Proyecto de Mejoramiento y Ampliación de los Servicios del Sistema Nacional de Ciencia, Tecnología e Innovación Tecnológica" [contract: 08-2019-FONDECYT-BM-INC-INV&...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2021 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/3001 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/3001 https://doi.org/10.3947/IC.2021.0015 |
| Nivel de acceso: | acceso abierto |
| Materia: | Pseudomonas aeruginosa Acinetobacter baumannii Intensive Care Unit Klebsiella pneumoniae Multidrug resistance https://purl.org/pe-repo/ocde/ford#3.03.01 |
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| dc.title.none.fl_str_mv |
Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital |
| title |
Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital |
| spellingShingle |
Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital Flores-Paredes W. Pseudomonas aeruginosa Acinetobacter baumannii Acinetobacter baumannii Intensive Care Unit Klebsiella pneumoniae Klebsiella pneumoniae Multidrug resistance https://purl.org/pe-repo/ocde/ford#3.03.01 |
| title_short |
Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital |
| title_full |
Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital |
| title_fullStr |
Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital |
| title_full_unstemmed |
Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital |
| title_sort |
Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital |
| author |
Flores-Paredes W. |
| author_facet |
Flores-Paredes W. Luque N. Albornoz R. Rojas, N. Espinoza M. Pons M.J. Ruiz J. |
| author_role |
author |
| author2 |
Luque N. Albornoz R. Rojas, N. Espinoza M. Pons M.J. Ruiz J. |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Flores-Paredes W. Luque N. Albornoz R. Rojas, N. Espinoza M. Pons M.J. Ruiz J. |
| dc.subject.none.fl_str_mv |
Pseudomonas aeruginosa |
| topic |
Pseudomonas aeruginosa Acinetobacter baumannii Acinetobacter baumannii Intensive Care Unit Klebsiella pneumoniae Klebsiella pneumoniae Multidrug resistance https://purl.org/pe-repo/ocde/ford#3.03.01 |
| dc.subject.es_PE.fl_str_mv |
Acinetobacter baumannii Acinetobacter baumannii Intensive Care Unit Klebsiella pneumoniae Klebsiella pneumoniae Multidrug resistance |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.03.01 |
| description |
JR was supported by Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT - Perú) within the “Proyecto de Mejoramiento y Ampliación de los Servicios del Sistema Nacional de Ciencia, Tecnología e Innovación Tecnológica" [contract: 08-2019-FONDECYT-BM-INC-INV"]. |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/3001 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3947/IC.2021.0015 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85115123324 |
| url |
https://hdl.handle.net/20.500.12390/3001 https://doi.org/10.3947/IC.2021.0015 |
| identifier_str_mv |
2-s2.0-85115123324 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Infection and Chemotherapy |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.publisher.none.fl_str_mv |
Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS |
| publisher.none.fl_str_mv |
Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS |
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reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
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Consejo Nacional de Ciencia Tecnología e Innovación |
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CONCYTEC |
| institution |
CONCYTEC |
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CONCYTEC-Institucional |
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CONCYTEC-Institucional |
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Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1839175508199211008 |
| spelling |
Publicationrp08527600rp08528600rp08530600rp06429600rp08529600rp01161600rp01358600Flores-Paredes W.Luque N.Albornoz R.Rojas, N.Espinoza M.Pons M.J.Ruiz J.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2021https://hdl.handle.net/20.500.12390/3001https://doi.org/10.3947/IC.2021.00152-s2.0-85115123324JR was supported by Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT - Perú) within the “Proyecto de Mejoramiento y Ampliación de los Servicios del Sistema Nacional de Ciencia, Tecnología e Innovación Tecnológica" [contract: 08-2019-FONDECYT-BM-INC-INV"].Backgound: The members of the so-called ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) are a frequent cause of severe infection, ranking among the most relevant causes of hospital infections. In Peru, few studies, often focused in a single ESKAPE microorganism, have been performed, but none providing an overall and comprehensive long-time analysis of the antibiotic resistance of ESKAPE microorganisms. In the present study, the evolution of antimicrobial resistance levels of ESKAPE microorganisms isolated during 2009 - 2010 (Period 1) and 2012 - 2014 (Period 2) in a IV-level hospital in Lima was analyzed. Materials and Methods: ESKAPE microorganisms were isolated from inpatients clinical samples. Bacterial identification, as well as antimicrobial susceptibility levels for up to 29 antimicrobial agents and presence of Extended-Spectrum ?-Lactamases (only established in K. pneumoniae) were determined using automatic methods. Results: Of 9,918 clinical isolates, 1,917/3,777 (50.8%) [JAN/2009-JUN/2010 (Period 1)] and 4764/6141 (46.4%) [JAN/2012-DEC/2014 (Period 2)] belonged to the ESKAPE group (P <0.0001). ESKAPE were more frequent in the intensive care unit (ICU) (P <0.0001). E. faecium decreased from 5.1% to 4.1% (P <0.5), S. aureus from 10.5% to 7.0% (P <0.05), and P. aeruginosa from 12.9% to 11.6% (P <0.05), while, A. baumannii increased from 5.0% to 6.7% (P <0.05), mainly related to an increase in ICU isolates (8.4% vs. 17.1%; P <0.05). Overall, high levels of antimicrobial resistance were detected, but with few exceptions (e.g. vancomycin in E. faecium), antibiotic resistance levels remained stable or lower in Period 2. Contrarily, A. baumannii showed significantly increased resistance to different cephalosporins, carbapenems and amoxicillin plus sulbactam. Conclusion: The introduction of a successful extensively drug-resistant A. baumannii clone in the ICU is suspected. The isolation of ESKAPE and levels of antibiotic resistance levels have reduced over time. © 2021 by The Korean Society of Infectious Diseases.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengKorean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDSInfection and Chemotherapyinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/Pseudomonas aeruginosaAcinetobacter baumannii-1Acinetobacter baumannii-1Intensive Care Unit-1Klebsiella pneumoniae-1Klebsiella pneumoniae-1Multidrug resistance-1https://purl.org/pe-repo/ocde/ford#3.03.01-1Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospitalinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/3001oai:repositorio.concytec.gob.pe:20.500.12390/30012024-05-30 16:12:59.903https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="3dfc1892-f176-4e19-aa19-15e9a0204763"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital</Title> <PublishedIn> <Publication> <Title>Infection and Chemotherapy</Title> </Publication> </PublishedIn> <PublicationDate>2021</PublicationDate> <DOI>https://doi.org/10.3947/IC.2021.0015</DOI> <SCP-Number>2-s2.0-85115123324</SCP-Number> <Authors> <Author> <DisplayName>Flores-Paredes W.</DisplayName> <Person id="rp08527" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Luque N.</DisplayName> <Person id="rp08528" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Albornoz R.</DisplayName> <Person id="rp08530" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Rojas, N.</DisplayName> <Person id="rp06429" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Espinoza M.</DisplayName> <Person id="rp08529" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Pons M.J.</DisplayName> <Person id="rp01161" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Ruiz J.</DisplayName> <Person id="rp01358" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by-nc-nd/4.0/</License> <Keyword>Pseudomonas aeruginosa</Keyword> <Keyword>Acinetobacter baumannii</Keyword> <Keyword>Acinetobacter baumannii</Keyword> <Keyword>Intensive Care Unit</Keyword> <Keyword>Klebsiella pneumoniae</Keyword> <Keyword>Klebsiella pneumoniae</Keyword> <Keyword>Multidrug resistance</Keyword> <Abstract>Backgound: The members of the so-called ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) are a frequent cause of severe infection, ranking among the most relevant causes of hospital infections. In Peru, few studies, often focused in a single ESKAPE microorganism, have been performed, but none providing an overall and comprehensive long-time analysis of the antibiotic resistance of ESKAPE microorganisms. In the present study, the evolution of antimicrobial resistance levels of ESKAPE microorganisms isolated during 2009 - 2010 (Period 1) and 2012 - 2014 (Period 2) in a IV-level hospital in Lima was analyzed. Materials and Methods: ESKAPE microorganisms were isolated from inpatients clinical samples. Bacterial identification, as well as antimicrobial susceptibility levels for up to 29 antimicrobial agents and presence of Extended-Spectrum ?-Lactamases (only established in K. pneumoniae) were determined using automatic methods. Results: Of 9,918 clinical isolates, 1,917/3,777 (50.8%) [JAN/2009-JUN/2010 (Period 1)] and 4764/6141 (46.4%) [JAN/2012-DEC/2014 (Period 2)] belonged to the ESKAPE group (P <0.0001). ESKAPE were more frequent in the intensive care unit (ICU) (P <0.0001). E. faecium decreased from 5.1% to 4.1% (P <0.5), S. aureus from 10.5% to 7.0% (P <0.05), and P. aeruginosa from 12.9% to 11.6% (P <0.05), while, A. baumannii increased from 5.0% to 6.7% (P <0.05), mainly related to an increase in ICU isolates (8.4% vs. 17.1%; P <0.05). Overall, high levels of antimicrobial resistance were detected, but with few exceptions (e.g. vancomycin in E. faecium), antibiotic resistance levels remained stable or lower in Period 2. Contrarily, A. baumannii showed significantly increased resistance to different cephalosporins, carbapenems and amoxicillin plus sulbactam. Conclusion: The introduction of a successful extensively drug-resistant A. baumannii clone in the ICU is suspected. The isolation of ESKAPE and levels of antibiotic resistance levels have reduced over time. © 2021 by The Korean Society of Infectious Diseases.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.439101 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
