Type 3 secretion system as an anti-Pseudomonal target

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Type 3 secretion systems (T3SSs) are a series of mechanisms involved in bacterial pathogenesis. While Pseudomonas aeruginosa only possess one T3SS, it plays a key role in the virulence of P. aeruginosa virulence. This finding suggests that T3SS impairment may be an alternative for antimicrobial agen...

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Detalles Bibliográficos
Autores: Horna G., Ruiz J.
Formato: revisión
Fecha de Publicación:2021
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/2324
Enlace del recurso:https://hdl.handle.net/20.500.12390/2324
https://doi.org/10.1016/j.micpath.2021.104907
Nivel de acceso:acceso abierto
Materia:T3SS inhibitors
Anti-virulence
PcrV vaccines
Pseudomonas aeruginosa
T3SS
http://purl.org/pe-repo/ocde/ford#3.01.01
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spelling Publicationrp05548600rp01358600Horna G.Ruiz J.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2021https://hdl.handle.net/20.500.12390/2324https://doi.org/10.1016/j.micpath.2021.1049072-s2.0-85105074879Type 3 secretion systems (T3SSs) are a series of mechanisms involved in bacterial pathogenesis. While Pseudomonas aeruginosa only possess one T3SS, it plays a key role in the virulence of P. aeruginosa virulence. This finding suggests that T3SS impairment may be an alternative for antimicrobial agents, allowing P. aeruginosa infections to be directly combated avoiding antimicrobial pressure on this and other microorganisms. To date, different approaches have been proposed, including T3SS inhibition, vaccination strategies, development of anti-T3SS antibodies and gene silencing. © 2021 Elsevier LtdConsejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengAcademic PressMicrobial Pathogenesisinfo:eu-repo/semantics/openAccessT3SS inhibitorsAnti-virulence-1PcrV vaccines-1Pseudomonas aeruginosa-1T3SS-1http://purl.org/pe-repo/ocde/ford#3.01.01-1Type 3 secretion system as an anti-Pseudomonal targetinfo:eu-repo/semantics/reviewreponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/2324oai:repositorio.concytec.gob.pe:20.500.12390/23242024-05-30 16:07:09.621http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="f3cf10d6-bc58-453b-a724-4740af913f2a"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Type 3 secretion system as an anti-Pseudomonal target</Title> <PublishedIn> <Publication> <Title>Microbial Pathogenesis</Title> </Publication> </PublishedIn> <PublicationDate>2021</PublicationDate> <DOI>https://doi.org/10.1016/j.micpath.2021.104907</DOI> <SCP-Number>2-s2.0-85105074879</SCP-Number> <Authors> <Author> <DisplayName>Horna G.</DisplayName> <Person id="rp05548" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Ruiz J.</DisplayName> <Person id="rp01358" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Academic Press</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>T3SS inhibitors</Keyword> <Keyword>Anti-virulence</Keyword> <Keyword>PcrV vaccines</Keyword> <Keyword>Pseudomonas aeruginosa</Keyword> <Keyword>T3SS</Keyword> <Abstract>Type 3 secretion systems (T3SSs) are a series of mechanisms involved in bacterial pathogenesis. While Pseudomonas aeruginosa only possess one T3SS, it plays a key role in the virulence of P. aeruginosa virulence. This finding suggests that T3SS impairment may be an alternative for antimicrobial agents, allowing P. aeruginosa infections to be directly combated avoiding antimicrobial pressure on this and other microorganisms. To date, different approaches have been proposed, including T3SS inhibition, vaccination strategies, development of anti-T3SS antibodies and gene silencing. © 2021 Elsevier Ltd</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
dc.title.none.fl_str_mv Type 3 secretion system as an anti-Pseudomonal target
title Type 3 secretion system as an anti-Pseudomonal target
spellingShingle Type 3 secretion system as an anti-Pseudomonal target
Horna G.
T3SS inhibitors
Anti-virulence
PcrV vaccines
Pseudomonas aeruginosa
T3SS
http://purl.org/pe-repo/ocde/ford#3.01.01
title_short Type 3 secretion system as an anti-Pseudomonal target
title_full Type 3 secretion system as an anti-Pseudomonal target
title_fullStr Type 3 secretion system as an anti-Pseudomonal target
title_full_unstemmed Type 3 secretion system as an anti-Pseudomonal target
title_sort Type 3 secretion system as an anti-Pseudomonal target
author Horna G.
author_facet Horna G.
Ruiz J.
author_role author
author2 Ruiz J.
author2_role author
dc.contributor.author.fl_str_mv Horna G.
Ruiz J.
dc.subject.none.fl_str_mv T3SS inhibitors
topic T3SS inhibitors
Anti-virulence
PcrV vaccines
Pseudomonas aeruginosa
T3SS
http://purl.org/pe-repo/ocde/ford#3.01.01
dc.subject.es_PE.fl_str_mv Anti-virulence
PcrV vaccines
Pseudomonas aeruginosa
T3SS
dc.subject.ocde.none.fl_str_mv http://purl.org/pe-repo/ocde/ford#3.01.01
description Type 3 secretion systems (T3SSs) are a series of mechanisms involved in bacterial pathogenesis. While Pseudomonas aeruginosa only possess one T3SS, it plays a key role in the virulence of P. aeruginosa virulence. This finding suggests that T3SS impairment may be an alternative for antimicrobial agents, allowing P. aeruginosa infections to be directly combated avoiding antimicrobial pressure on this and other microorganisms. To date, different approaches have been proposed, including T3SS inhibition, vaccination strategies, development of anti-T3SS antibodies and gene silencing. © 2021 Elsevier Ltd
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/review
format review
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/2324
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.micpath.2021.104907
dc.identifier.scopus.none.fl_str_mv 2-s2.0-85105074879
url https://hdl.handle.net/20.500.12390/2324
https://doi.org/10.1016/j.micpath.2021.104907
identifier_str_mv 2-s2.0-85105074879
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Microbial Pathogenesis
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Academic Press
publisher.none.fl_str_mv Academic Press
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
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score 13.39606
Type 3 secretion system as an anti-Pseudomonal target
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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

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