Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus)
Descripción del Articulo
Cesar Franco-Quino is a doctoral student studying an Epidemiological Research Doctorate at Universidad Peruana Cayetano Heredia under FONDECYT/CIENCIACTIVA scholarship EF033-235-2015 and supported by training grant D43 TW007393 awarded by Fogarti International Center of the US National Institutes of...
| Autores: | , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2019 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/2753 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/2753 https://doi.org/10.5530/PJ.2019.11.237 |
| Nivel de acceso: | acceso abierto |
| Materia: | Subchronic Toxicity Genotoxicity Plukenetia Volubilis Sacha Inchi Oil http://purl.org/pe-repo/ocde/ford#3.01.05 |
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| dc.title.none.fl_str_mv |
Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus) |
| title |
Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus) |
| spellingShingle |
Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus) Herrera-Calderon, Oscar Subchronic Toxicity Genotoxicity Plukenetia Volubilis Sacha Inchi Oil http://purl.org/pe-repo/ocde/ford#3.01.05 |
| title_short |
Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus) |
| title_full |
Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus) |
| title_fullStr |
Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus) |
| title_full_unstemmed |
Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus) |
| title_sort |
Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus) |
| author |
Herrera-Calderon, Oscar |
| author_facet |
Herrera-Calderon, Oscar Arroyo-Acevedo, Jorge Luis Chávez-Asmat, Roberto Rojas-Armas, Juan Pedro Enciso-Roca, Edwin Chumpitaz Cerrate, Victor Franco-Quino, Cesar Chacaltana-Ramos, Luz Yuli-Posadas, Ricardo Ángel |
| author_role |
author |
| author2 |
Arroyo-Acevedo, Jorge Luis Chávez-Asmat, Roberto Rojas-Armas, Juan Pedro Enciso-Roca, Edwin Chumpitaz Cerrate, Victor Franco-Quino, Cesar Chacaltana-Ramos, Luz Yuli-Posadas, Ricardo Ángel |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Herrera-Calderon, Oscar Arroyo-Acevedo, Jorge Luis Chávez-Asmat, Roberto Rojas-Armas, Juan Pedro Enciso-Roca, Edwin Chumpitaz Cerrate, Victor Franco-Quino, Cesar Chacaltana-Ramos, Luz Yuli-Posadas, Ricardo Ángel |
| dc.subject.none.fl_str_mv |
Subchronic Toxicity |
| topic |
Subchronic Toxicity Genotoxicity Plukenetia Volubilis Sacha Inchi Oil http://purl.org/pe-repo/ocde/ford#3.01.05 |
| dc.subject.es_PE.fl_str_mv |
Genotoxicity Plukenetia Volubilis Sacha Inchi Oil |
| dc.subject.ocde.none.fl_str_mv |
http://purl.org/pe-repo/ocde/ford#3.01.05 |
| description |
Cesar Franco-Quino is a doctoral student studying an Epidemiological Research Doctorate at Universidad Peruana Cayetano Heredia under FONDECYT/CIENCIACTIVA scholarship EF033-235-2015 and supported by training grant D43 TW007393 awarded by Fogarti International Center of the US National Institutes of Health. |
| publishDate |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/2753 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.5530/PJ.2019.11.237 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85077310260 |
| url |
https://hdl.handle.net/20.500.12390/2753 https://doi.org/10.5530/PJ.2019.11.237 |
| identifier_str_mv |
2-s2.0-85077310260 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Pharmacognosy Journal |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| dc.publisher.none.fl_str_mv |
EManuscript Technologies |
| publisher.none.fl_str_mv |
EManuscript Technologies |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
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Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
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CONCYTEC-Institucional |
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CONCYTEC-Institucional |
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Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883115413078016 |
| spelling |
Publicationrp07349600rp07370600rp07371600rp07373600rp07346600rp07369600rp07347600rp07372600rp07348600Herrera-Calderon, OscarArroyo-Acevedo, Jorge LuisChávez-Asmat, RobertoRojas-Armas, Juan PedroEnciso-Roca, EdwinChumpitaz Cerrate, VictorFranco-Quino, CesarChacaltana-Ramos, LuzYuli-Posadas, Ricardo Ángel2024-05-30T23:13:38Z2024-05-30T23:13:38Z2019https://hdl.handle.net/20.500.12390/2753https://doi.org/10.5530/PJ.2019.11.2372-s2.0-85077310260Cesar Franco-Quino is a doctoral student studying an Epidemiological Research Doctorate at Universidad Peruana Cayetano Heredia under FONDECYT/CIENCIACTIVA scholarship EF033-235-2015 and supported by training grant D43 TW007393 awarded by Fogarti International Center of the US National Institutes of Health.Introduction: Plukenetia volubilis is known as Sacha Inchi (SI) is originary from the peruvian amazone and it has been cultivated and consumed since the pre and Inca's time. Objective: Sacha inchi oil was assessed for genotoxicity in Balb C albino mice and subchronic toxicity in goldfish (Carassius auratus). Material and Methods: The genotoxicity was assessed in Mus musculus Balb C (n = 25) separated into five groups randomly selected of twenty-five each one. Groups were 10 mL / kg normal saline (NS), 40 mg / kg cyclophosphamide group (CP) and the three other groups received cyclophosphamide and sacha inchi oil of concentrations 10, 100 and 1000 mg / kg respectively. The substances were administered three times during 24 hours. The genotoxicity in mice was evaluated determining micronucleus levels in blood and bone marrow. The subchronic toxicity was assessed in goldfish (Carassius auratus) (n = 48) separated into four groups randomly selected of six each: normal saline group (control) and three groups that received doses of 10, 100 and 1000 µg sacha inchi oil per litre of water respectively for 45 days. Results:The values of weight, length, growth rate, condition factor (K) and number of survivors were recorded. CP group showed higher micronuclei levels in blood and bone marrow compared with sacha inchi oil 10, 100 and 1000 mg / kg groups (ANOVA Test p <0.01 Scheffe´s Post Hoc p <0.05, p <0.01 and p <0.001 respectively). The subchronic toxicity assessment in goldfish showed isometric growth, a decline in "K" and a similar specific percentage growth rate per day in all groups (ANOVA test p> 0.05). Conclusion: Sacha inchi oil was not toxic under experimental conditions. © 2019 Phcogj.Com.Fondo Nacional de Desarrollo Científico y Tecnológico - FondecytengEManuscript TechnologiesPharmacognosy Journalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Subchronic ToxicityGenotoxicity-1Plukenetia Volubilis-1Sacha Inchi Oil-1http://purl.org/pe-repo/ocde/ford#3.01.05-1Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus)info:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/2753oai:repositorio.concytec.gob.pe:20.500.12390/27532024-05-30 15:25:29.417https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="676240c2-752d-4e98-af44-f8e107cd1f95"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Effect of sacha inchi oil (Plukenetia volubilis L.) on genotoxicity in mice (Mus musculus) and subchronic toxicity in goldfish (Carassius auratus)</Title> <PublishedIn> <Publication> <Title>Pharmacognosy Journal</Title> </Publication> </PublishedIn> <PublicationDate>2019</PublicationDate> <DOI>https://doi.org/10.5530/PJ.2019.11.237</DOI> <SCP-Number>2-s2.0-85077310260</SCP-Number> <Authors> <Author> <DisplayName>Herrera-Calderon, Oscar</DisplayName> <Person id="rp07349" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Arroyo-Acevedo, Jorge Luis</DisplayName> <Person id="rp07370" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chávez-Asmat, Roberto</DisplayName> <Person id="rp07371" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Rojas-Armas, Juan Pedro</DisplayName> <Person id="rp07373" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Enciso-Roca, Edwin</DisplayName> <Person id="rp07346" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chumpitaz Cerrate, Victor</DisplayName> <Person id="rp07369" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Franco-Quino, Cesar</DisplayName> <Person id="rp07347" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chacaltana-Ramos, Luz</DisplayName> <Person id="rp07372" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Yuli-Posadas, Ricardo Ángel</DisplayName> <Person id="rp07348" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>EManuscript Technologies</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by/4.0/</License> <Keyword>Subchronic Toxicity</Keyword> <Keyword>Genotoxicity</Keyword> <Keyword>Plukenetia Volubilis</Keyword> <Keyword>Sacha Inchi Oil</Keyword> <Abstract>Introduction: Plukenetia volubilis is known as Sacha Inchi (SI) is originary from the peruvian amazone and it has been cultivated and consumed since the pre and Inca's time. Objective: Sacha inchi oil was assessed for genotoxicity in Balb C albino mice and subchronic toxicity in goldfish (Carassius auratus). Material and Methods: The genotoxicity was assessed in Mus musculus Balb C (n = 25) separated into five groups randomly selected of twenty-five each one. Groups were 10 mL / kg normal saline (NS), 40 mg / kg cyclophosphamide group (CP) and the three other groups received cyclophosphamide and sacha inchi oil of concentrations 10, 100 and 1000 mg / kg respectively. The substances were administered three times during 24 hours. The genotoxicity in mice was evaluated determining micronucleus levels in blood and bone marrow. The subchronic toxicity was assessed in goldfish (Carassius auratus) (n = 48) separated into four groups randomly selected of six each: normal saline group (control) and three groups that received doses of 10, 100 and 1000 µg sacha inchi oil per litre of water respectively for 45 days. Results:The values of weight, length, growth rate, condition factor (K) and number of survivors were recorded. CP group showed higher micronuclei levels in blood and bone marrow compared with sacha inchi oil 10, 100 and 1000 mg / kg groups (ANOVA Test p <0.01 Scheffe´s Post Hoc p <0.05, p <0.01 and p <0.001 respectively). The subchronic toxicity assessment in goldfish showed isometric growth, a decline in "K" and a similar specific percentage growth rate per day in all groups (ANOVA test p> 0.05). Conclusion: Sacha inchi oil was not toxic under experimental conditions. © 2019 Phcogj.Com.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
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13.1017275 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
