Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes

Descripción del Articulo

This work was supported in part by a grant from the Consejo Nacional de Ciencia y Tecnologla (CONCYTEC). We thank W. Behrens and C. Santa Cruz for helpful advice on HPLC analysis and T. cruzi culture, and H. Guerra and C. Guerra for critically reading the manuscript.
Detalles Bibliográficos
Autores: Clark D., Albrecht M., Arévalo J.
Formato: artículo
Fecha de Publicación:1994
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/793
Enlace del recurso:https://hdl.handle.net/20.500.12390/793
https://doi.org/10.1016/0166-6851(94)90045-0
Nivel de acceso:acceso abierto
Materia:dehydroascorbic acid reductase
ascorbic acid
animal experiment
https://purl.org/pe-repo/ocde/ford#1.06.03
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oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/793
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes
title Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes
spellingShingle Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes
Clark D.
dehydroascorbic acid reductase
ascorbic acid
animal experiment
https://purl.org/pe-repo/ocde/ford#1.06.03
title_short Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes
title_full Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes
title_fullStr Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes
title_full_unstemmed Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes
title_sort Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes
author Clark D.
author_facet Clark D.
Albrecht M.
Arévalo J.
author_role author
author2 Albrecht M.
Arévalo J.
author2_role author
author
dc.contributor.author.fl_str_mv Clark D.
Albrecht M.
Arévalo J.
dc.subject.none.fl_str_mv dehydroascorbic acid reductase
topic dehydroascorbic acid reductase
ascorbic acid
animal experiment
https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.es_PE.fl_str_mv ascorbic acid
animal experiment
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#1.06.03
description This work was supported in part by a grant from the Consejo Nacional de Ciencia y Tecnologla (CONCYTEC). We thank W. Behrens and C. Santa Cruz for helpful advice on HPLC analysis and T. cruzi culture, and H. Guerra and C. Guerra for critically reading the manuscript.
publishDate 1994
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 1994
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/793
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/0166-6851(94)90045-0
dc.identifier.scopus.none.fl_str_mv 2-s2.0-0028148024
url https://hdl.handle.net/20.500.12390/793
https://doi.org/10.1016/0166-6851(94)90045-0
identifier_str_mv 2-s2.0-0028148024
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Molecular and Biochemical Parasitology
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
_version_ 1844883070368350208
spelling Publicationrp01998500rp02038600rp01883500Clark D.Albrecht M.Arévalo J.2024-05-30T23:13:38Z2024-05-30T23:13:38Z1994https://hdl.handle.net/20.500.12390/793https://doi.org/10.1016/0166-6851(94)90045-02-s2.0-0028148024This work was supported in part by a grant from the Consejo Nacional de Ciencia y Tecnologla (CONCYTEC). We thank W. Behrens and C. Santa Cruz for helpful advice on HPLC analysis and T. cruzi culture, and H. Guerra and C. Guerra for critically reading the manuscript.Trypanosoma cruzi, the causative agent of Chagas' disease, has been considered for many years as an organism with limited capability to metabolize hydrogen peroxide (H202) [1]. This was supported by undetectable levels of peroxide-removing enzymes (catalase, glutathione peroxidase) and its high sensitivity to drugs like fl-lapachone and nifurtimox that generate superoxide anion (02-) and H202 through intracellular nitroreductases [2]. Paradoxically, T. cruzi parasites are naturally exposed to endogenous and exogenously generated reactive oxygen species through their life cycle. Microsomal and mitochondrial fractions, as well as fumarate reductase from T. cruzi can generate 02- and H202 [2,3]. Furthermore, the parasite can eventually be exposed to an oxidative stress when taken up by macrophages [4,5].Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengElsevierMolecular and Biochemical Parasitologyinfo:eu-repo/semantics/openAccessdehydroascorbic acid reductaseascorbic acid-1animal experiment-1https://purl.org/pe-repo/ocde/ford#1.06.03-1Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotesinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/793oai:repositorio.concytec.gob.pe:20.500.12390/7932024-05-30 15:22:57.685http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="2c2ff4a5-c1d4-4020-a629-54a22dca01e6"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes</Title> <PublishedIn> <Publication> <Title>Molecular and Biochemical Parasitology</Title> </Publication> </PublishedIn> <PublicationDate>1994</PublicationDate> <DOI>https://doi.org/10.1016/0166-6851(94)90045-0</DOI> <SCP-Number>2-s2.0-0028148024</SCP-Number> <Authors> <Author> <DisplayName>Clark D.</DisplayName> <Person id="rp01998" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Albrecht M.</DisplayName> <Person id="rp02038" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Arévalo J.</DisplayName> <Person id="rp01883" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Elsevier</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>dehydroascorbic acid reductase</Keyword> <Keyword>ascorbic acid</Keyword> <Keyword>animal experiment</Keyword> <Abstract>Trypanosoma cruzi, the causative agent of Chagas&apos; disease, has been considered for many years as an organism with limited capability to metabolize hydrogen peroxide (H202) [1]. This was supported by undetectable levels of peroxide-removing enzymes (catalase, glutathione peroxidase) and its high sensitivity to drugs like fl-lapachone and nifurtimox that generate superoxide anion (02-) and H202 through intracellular nitroreductases [2]. Paradoxically, T. cruzi parasites are naturally exposed to endogenous and exogenously generated reactive oxygen species through their life cycle. Microsomal and mitochondrial fractions, as well as fumarate reductase from T. cruzi can generate 02- and H202 [2,3]. Furthermore, the parasite can eventually be exposed to an oxidative stress when taken up by macrophages [4,5].</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.466479
Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes
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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

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