Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice
Descripción del Articulo
VM was a recipient of an FPI fellowship and from Ciberned. This work was funded by grant SAF2013-40710-R and by Ciberned and JZ waspartially supported by Cienciactiva, an initiative of the the National Council of Science, Technology and Technological Innovation-CONCYTEC, Perú.
| Autores: | , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2019 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/975 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/975 https://doi.org/10.18632/aging.101739 |
| Nivel de acceso: | acceso abierto |
| Materia: | reproductive aging estrogen exercise insulin-like growth factor 1 mood https://purl.org/pe-repo/ocde/ford#3.02.00 |
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| dc.title.none.fl_str_mv |
Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice |
| title |
Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice |
| spellingShingle |
Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice Munive, V reproductive aging estrogen exercise insulin-like growth factor 1 mood https://purl.org/pe-repo/ocde/ford#3.02.00 |
| title_short |
Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice |
| title_full |
Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice |
| title_fullStr |
Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice |
| title_full_unstemmed |
Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice |
| title_sort |
Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice |
| author |
Munive, V |
| author_facet |
Munive, V Zegarra-Valdivia, JA Herrero-Labrador, R Fernandez, AM Aleman, IT |
| author_role |
author |
| author2 |
Zegarra-Valdivia, JA Herrero-Labrador, R Fernandez, AM Aleman, IT |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Munive, V Zegarra-Valdivia, JA Herrero-Labrador, R Fernandez, AM Aleman, IT |
| dc.subject.none.fl_str_mv |
reproductive aging |
| topic |
reproductive aging estrogen exercise insulin-like growth factor 1 mood https://purl.org/pe-repo/ocde/ford#3.02.00 |
| dc.subject.es_PE.fl_str_mv |
estrogen exercise insulin-like growth factor 1 mood |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.02.00 |
| description |
VM was a recipient of an FPI fellowship and from Ciberned. This work was funded by grant SAF2013-40710-R and by Ciberned and JZ waspartially supported by Cienciactiva, an initiative of the the National Council of Science, Technology and Technological Innovation-CONCYTEC, Perú. |
| publishDate |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/975 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.18632/aging.101739 |
| dc.identifier.isi.none.fl_str_mv |
459886600019 |
| url |
https://hdl.handle.net/20.500.12390/975 https://doi.org/10.18632/aging.101739 |
| identifier_str_mv |
459886600019 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
AGING-US |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by/3.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by/3.0/ |
| dc.publisher.none.fl_str_mv |
AGING |
| publisher.none.fl_str_mv |
AGING |
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reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
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Consejo Nacional de Ciencia Tecnología e Innovación |
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CONCYTEC |
| institution |
CONCYTEC |
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CONCYTEC-Institucional |
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CONCYTEC-Institucional |
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Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883100511764480 |
| spelling |
Publicationrp02670600rp02671600rp02672600rp02673600rp01083500Munive, VZegarra-Valdivia, JAHerrero-Labrador, RFernandez, AMAleman, IT2024-05-30T23:13:38Z2024-05-30T23:13:38Z2019https://hdl.handle.net/20.500.12390/975https://doi.org/10.18632/aging.101739459886600019VM was a recipient of an FPI fellowship and from Ciberned. This work was funded by grant SAF2013-40710-R and by Ciberned and JZ waspartially supported by Cienciactiva, an initiative of the the National Council of Science, Technology and Technological Innovation-CONCYTEC, Perú.We recently reported that exercise increases resilience to stress in young female mice. Underlying mechanisms include an interaction of the ovarian hormone estradiol (E2) with insulin-like growth factor I (IGF-I), and an increase in the hippocampal levels of the latter. Since changes in mood regulation during aging may contribute to increasing incidence of affective disorders at older age, we determined whether the protective actions of exercise are maintained at later ages. We found that during peri-menopause, exercise no longer improves resilience to stress and even becomes anxiogenic. Furthermore, the interaction seen in young females between the E2 α receptor (ERα) and the IGF-I receptor (IGF-IR) is lost at middle-age. In addition, E2 no longer induces IGF-I uptake by brain endothelial cells, and consequently, hippocampal IGF-I levels do not increase. Treatment of middle-aged females with an ERα agonist did not recover the positive actions of exercise. Collectively, these data indicate that the loss of action of exercise during peri-menopause may be related to a loss of the interaction of IGF-IR with ERα in brain endothelial cells that cannot be ameliorated by estrogen therapy. Changes in regulation of mood by physical activity may contribute to increased appearance of affective disorders along age.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengAGINGAGING-USinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/3.0/reproductive agingestrogen-1exercise-1insulin-like growth factor 1-1mood-1https://purl.org/pe-repo/ocde/ford#3.02.00-1Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in miceinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/975oai:repositorio.concytec.gob.pe:20.500.12390/9752024-05-30 15:23:24.579https://creativecommons.org/licenses/by/3.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="54d2cced-d783-475d-b3a5-77f3f7ae187e"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice</Title> <PublishedIn> <Publication> <Title>AGING-US</Title> </Publication> </PublishedIn> <PublicationDate>2019</PublicationDate> <DOI>https://doi.org/10.18632/aging.101739</DOI> <ISI-Number>459886600019</ISI-Number> <Authors> <Author> <DisplayName>Munive, V</DisplayName> <Person id="rp02670" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Zegarra-Valdivia, JA</DisplayName> <Person id="rp02671" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Herrero-Labrador, R</DisplayName> <Person id="rp02672" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Fernandez, AM</DisplayName> <Person id="rp02673" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Aleman, IT</DisplayName> <Person id="rp01083" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>AGING</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by/3.0/</License> <Keyword>reproductive aging</Keyword> <Keyword>estrogen</Keyword> <Keyword>exercise</Keyword> <Keyword>insulin-like growth factor 1</Keyword> <Keyword>mood</Keyword> <Abstract>We recently reported that exercise increases resilience to stress in young female mice. Underlying mechanisms include an interaction of the ovarian hormone estradiol (E2) with insulin-like growth factor I (IGF-I), and an increase in the hippocampal levels of the latter. Since changes in mood regulation during aging may contribute to increasing incidence of affective disorders at older age, we determined whether the protective actions of exercise are maintained at later ages. We found that during peri-menopause, exercise no longer improves resilience to stress and even becomes anxiogenic. Furthermore, the interaction seen in young females between the E2 α receptor (ERα) and the IGF-I receptor (IGF-IR) is lost at middle-age. In addition, E2 no longer induces IGF-I uptake by brain endothelial cells, and consequently, hippocampal IGF-I levels do not increase. Treatment of middle-aged females with an ERα agonist did not recover the positive actions of exercise. Collectively, these data indicate that the loss of action of exercise during peri-menopause may be related to a loss of the interaction of IGF-IR with ERα in brain endothelial cells that cannot be ameliorated by estrogen therapy. Changes in regulation of mood by physical activity may contribute to increased appearance of affective disorders along age.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.457506 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
