Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process
Descripción del Articulo
Reconstitution of biologically active polymersomes from the frozen or solid state into any fluid state is still a challenging issue for the design of new biological experiments and for the formulation of therapeutic agents. To gain knowledge about the reconstitution of pH-responsive and photo-crossl...
| Autores: | , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2018 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/756 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/756 https://doi.org/10.1039/c8ra03964j |
| Nivel de acceso: | acceso abierto |
| Materia: | Therapeutic agents Biological experiments Cryogenic freezing Dispersing process Freeze-drying process Functionalized PH-responsive Polymersomes Functional polymers |
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CONC_08b23c5a95e790762fd273ed4a3d620a |
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| dc.title.none.fl_str_mv |
Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process |
| title |
Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process |
| spellingShingle |
Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process Ccorahua R. Therapeutic agents Biological experiments Cryogenic freezing Dispersing process Freeze-drying process Functionalized PH-responsive Polymersomes Functional polymers |
| title_short |
Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process |
| title_full |
Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process |
| title_fullStr |
Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process |
| title_full_unstemmed |
Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process |
| title_sort |
Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process |
| author |
Ccorahua R. |
| author_facet |
Ccorahua R. Moreno S. Gumz H. Sahre K. Voit B. Appelhans D. |
| author_role |
author |
| author2 |
Moreno S. Gumz H. Sahre K. Voit B. Appelhans D. |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Ccorahua R. Moreno S. Gumz H. Sahre K. Voit B. Appelhans D. |
| dc.subject.none.fl_str_mv |
Therapeutic agents |
| topic |
Therapeutic agents Biological experiments Cryogenic freezing Dispersing process Freeze-drying process Functionalized PH-responsive Polymersomes Functional polymers |
| dc.subject.es_PE.fl_str_mv |
Biological experiments Cryogenic freezing Dispersing process Freeze-drying process Functionalized PH-responsive Polymersomes Functional polymers |
| description |
Reconstitution of biologically active polymersomes from the frozen or solid state into any fluid state is still a challenging issue for the design of new biological experiments and for the formulation of therapeutic agents. To gain knowledge about the reconstitution of pH-responsive and photo-crosslinked polymersomes, surface-functionalized and enzyme-containing polymersomers were cryogenically frozen ( 20 C) or freeze-dried with inulin as the lyoprotectant (0.1% w/v) and stored for a defined time period. Reconstituting those polymersomes in solution by thawing or a re-dispersing process revealed their original physical properties as well as their function as a pH-switchable enzymatic nanoreactor. |
| publishDate |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2018 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/756 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1039/c8ra03964j |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85050508261 |
| url |
https://hdl.handle.net/20.500.12390/756 https://doi.org/10.1039/c8ra03964j |
| identifier_str_mv |
2-s2.0-85050508261 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
RSC Advances |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
| publisher.none.fl_str_mv |
Royal Society of Chemistry |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
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Consejo Nacional de Ciencia Tecnología e Innovación |
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CONCYTEC |
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CONCYTEC |
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CONCYTEC-Institucional |
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CONCYTEC-Institucional |
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Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883035966668800 |
| spelling |
Publicationrp01931600rp00014400rp01929600rp01933600rp01932600rp01930600Ccorahua R.Moreno S.Gumz H.Sahre K.Voit B.Appelhans D.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2018https://hdl.handle.net/20.500.12390/756https://doi.org/10.1039/c8ra03964j2-s2.0-85050508261Reconstitution of biologically active polymersomes from the frozen or solid state into any fluid state is still a challenging issue for the design of new biological experiments and for the formulation of therapeutic agents. To gain knowledge about the reconstitution of pH-responsive and photo-crosslinked polymersomes, surface-functionalized and enzyme-containing polymersomers were cryogenically frozen ( 20 C) or freeze-dried with inulin as the lyoprotectant (0.1% w/v) and stored for a defined time period. Reconstituting those polymersomes in solution by thawing or a re-dispersing process revealed their original physical properties as well as their function as a pH-switchable enzymatic nanoreactor.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengRoyal Society of ChemistryRSC Advancesinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Therapeutic agentsBiological experiments-1Cryogenic freezing-1Dispersing process-1Freeze-drying process-1Functionalized-1PH-responsive-1Polymersomes-1Functional polymers-1Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying processinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/756oai:repositorio.concytec.gob.pe:20.500.12390/7562025-09-22 16:27:30.433https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="d6fc5d65-f65d-49e4-9784-4e4e41c70588"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process</Title> <PublishedIn> <Publication> <Title>RSC Advances</Title> </Publication> </PublishedIn> <PublicationDate>2018</PublicationDate> <DOI>https://doi.org/10.1039/c8ra03964j</DOI> <SCP-Number>2-s2.0-85050508261</SCP-Number> <Authors> <Author> <DisplayName>Ccorahua R.</DisplayName> <Person id="rp01931" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Moreno S.</DisplayName> <Person id="rp00014" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gumz H.</DisplayName> <Person id="rp01929" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Sahre K.</DisplayName> <Person id="rp01933" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Voit B.</DisplayName> <Person id="rp01932" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Appelhans D.</DisplayName> <Person id="rp01930" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Royal Society of Chemistry</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by/4.0/</License> <Keyword>Therapeutic agents</Keyword> <Keyword>Biological experiments</Keyword> <Keyword>Cryogenic freezing</Keyword> <Keyword>Dispersing process</Keyword> <Keyword>Freeze-drying process</Keyword> <Keyword>Functionalized</Keyword> <Keyword>PH-responsive</Keyword> <Keyword>Polymersomes</Keyword> <Keyword>Functional polymers</Keyword> <Abstract>Reconstitution of biologically active polymersomes from the frozen or solid state into any fluid state is still a challenging issue for the design of new biological experiments and for the formulation of therapeutic agents. To gain knowledge about the reconstitution of pH-responsive and photo-crosslinked polymersomes, surface-functionalized and enzyme-containing polymersomers were cryogenically frozen ( 20 C) or freeze-dried with inulin as the lyoprotectant (0.1% w/v) and stored for a defined time period. Reconstituting those polymersomes in solution by thawing or a re-dispersing process revealed their original physical properties as well as their function as a pH-switchable enzymatic nanoreactor.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
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13.788314 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
