Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts
Descripción del Articulo
The authors gratefully acknowledge the financial assistance of CONCYTEC from Peru and DSF-IRD (JEAI) from France. We express our thanks to members of the Yanesha community who were willing to share with us their knowledge about medicinal plants. The authors are grateful to Candy Ruiz from LID-UPCH,...
| Autores: | , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2009 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/716 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/716 https://doi.org/10.1016/j.jep.2009.03.041 |
| Nivel de acceso: | acceso abierto |
| Materia: | hypoxanthine alcohol antileishmanial agent antimalarial agent Calea montana extract Carica papaya extract Cestrum racemosum extract chloroquine Hedychium coronarium extract https://purl.org/pe-repo/ocde/ford#3.01.05 |
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CONC |
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CONCYTEC-Institucional |
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4689 |
| dc.title.none.fl_str_mv |
Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts |
| title |
Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts |
| spellingShingle |
Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts Céline V. hypoxanthine alcohol antileishmanial agent antimalarial agent Calea montana extract Carica papaya extract Cestrum racemosum extract chloroquine Hedychium coronarium extract https://purl.org/pe-repo/ocde/ford#3.01.05 |
| title_short |
Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts |
| title_full |
Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts |
| title_fullStr |
Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts |
| title_full_unstemmed |
Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts |
| title_sort |
Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts |
| author |
Céline V. |
| author_facet |
Céline V. Adriana P. Eric D. Joaquina A. Yannick E. Augusto L.F. Rosario R. Dionicia G. Michel S. Denis C. Geneviève B. |
| author_role |
author |
| author2 |
Adriana P. Eric D. Joaquina A. Yannick E. Augusto L.F. Rosario R. Dionicia G. Michel S. Denis C. Geneviève B. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Céline V. Adriana P. Eric D. Joaquina A. Yannick E. Augusto L.F. Rosario R. Dionicia G. Michel S. Denis C. Geneviève B. |
| dc.subject.none.fl_str_mv |
hypoxanthine |
| topic |
hypoxanthine alcohol antileishmanial agent antimalarial agent Calea montana extract Carica papaya extract Cestrum racemosum extract chloroquine Hedychium coronarium extract https://purl.org/pe-repo/ocde/ford#3.01.05 |
| dc.subject.es_PE.fl_str_mv |
alcohol antileishmanial agent antimalarial agent Calea montana extract Carica papaya extract Cestrum racemosum extract chloroquine Hedychium coronarium extract |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.01.05 |
| description |
The authors gratefully acknowledge the financial assistance of CONCYTEC from Peru and DSF-IRD (JEAI) from France. We express our thanks to members of the Yanesha community who were willing to share with us their knowledge about medicinal plants. The authors are grateful to Candy Ruiz from LID-UPCH, for technical assistance in plants extractions. Céline Valadeau, Adriana Pabon and Denis Castillo received grants from the Institut Franc¸ ais des Etudes Andines, Colciencias and the Belgian technical cooperation respectively. Part of this work was supported by a grant from the International Foundation for Sciences attributed to Dionicia Gamboa |
| publishDate |
2009 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2009 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/716 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.jep.2009.03.041 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-67349122667 |
| url |
https://hdl.handle.net/20.500.12390/716 https://doi.org/10.1016/j.jep.2009.03.041 |
| identifier_str_mv |
2-s2.0-67349122667 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Journal of Ethnopharmacology |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1839175616699564032 |
| spelling |
Publicationrp01771600rp01778600rp01777600rp01780600rp01774600rp01772600rp01775600rp01776600rp00017400rp01773600rp01779600Céline V.Adriana P.Eric D.Joaquina A.Yannick E.Augusto L.F.Rosario R.Dionicia G.Michel S.Denis C.Geneviève B.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2009https://hdl.handle.net/20.500.12390/716https://doi.org/10.1016/j.jep.2009.03.0412-s2.0-67349122667The authors gratefully acknowledge the financial assistance of CONCYTEC from Peru and DSF-IRD (JEAI) from France. We express our thanks to members of the Yanesha community who were willing to share with us their knowledge about medicinal plants. The authors are grateful to Candy Ruiz from LID-UPCH, for technical assistance in plants extractions. Céline Valadeau, Adriana Pabon and Denis Castillo received grants from the Institut Franc¸ ais des Etudes Andines, Colciencias and the Belgian technical cooperation respectively. Part of this work was supported by a grant from the International Foundation for Sciences attributed to Dionicia GamboaAim of the study: Ninety-four ethanolic extracts of plants used medicinally by the Yanesha, an Amazonian Peruvian ethnic group, for affections related to leishmaniasis and malaria were screened in vitro against Leishmania amazonensis amastigotes and against a Plasmodium falciparum chloroquine resistant strain. Materials and methods: The viability of Leishmania amazonensis amastigote stages was assessed by the reduction of tetrazolium salt (MTT) while the impact on Plasmodium falciparum was determined by measuring the incorporation of radio-labelled hypoxanthine. Results and conclusions: Six plant species displayed good activity against Plasmodium falciparum chloroquine resistant strain (IC50 < 10 μg/ml): a Monimiaceae, Siparuna aspera (Ruiz & Pavon), A. DC., two Zingiberaceae, Renealmia thyrsoidea (Ruiz & Pavon) Poepp. & Endl. and Renealmia alpinia (Rottb.), two Piperaceae (Piper aduncum L. and Piper sp.) and the leaves of Jacaranda copaia (Aubl.) D. Don (Bignoniaceae). Eight species displayed interesting leishmanicidal activities (IC50 < 10 μg/ml): Carica papaya L. (Caricaceae), Piper dennisii Trel (Piperaceae), Hedychium coronarium J. König (Zingiberaceae), Cestrum racemosum Ruiz & Pav. (Solanaceae), Renealmia alpinia (Rottb.) Zingiberaceae, Lantana sp. (Verbenaceae), Hyptis lacustris A. St.-Hil. ex Benth. (Lamiaceae) and Calea montana Klat. (Asteraceae). Most of them are used against skin affections by Yanesha people. Results are discussed herein, according to the traditional use of the plants and compared with data obtained from the literature.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengElsevierJournal of Ethnopharmacologyinfo:eu-repo/semantics/openAccesshypoxanthinealcohol-1antileishmanial agent-1antimalarial agent-1Calea montana extract-1Carica papaya extract-1Cestrum racemosum extract-1chloroquine-1Hedychium coronarium extract-1https://purl.org/pe-repo/ocde/ford#3.01.05-1Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extractsinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/716oai:repositorio.concytec.gob.pe:20.500.12390/7162024-05-30 15:58:45.824http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="7dbe3111-4daa-4611-bbe0-a93c718d10cf"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts</Title> <PublishedIn> <Publication> <Title>Journal of Ethnopharmacology</Title> </Publication> </PublishedIn> <PublicationDate>2009</PublicationDate> <DOI>https://doi.org/10.1016/j.jep.2009.03.041</DOI> <SCP-Number>2-s2.0-67349122667</SCP-Number> <Authors> <Author> <DisplayName>Céline V.</DisplayName> <Person id="rp01771" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Adriana P.</DisplayName> <Person id="rp01778" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Eric D.</DisplayName> <Person id="rp01777" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Joaquina A.</DisplayName> <Person id="rp01780" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Yannick E.</DisplayName> <Person id="rp01774" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Augusto L.F.</DisplayName> <Person id="rp01772" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Rosario R.</DisplayName> <Person id="rp01775" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Dionicia G.</DisplayName> <Person id="rp01776" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Michel S.</DisplayName> <Person id="rp00017" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Denis C.</DisplayName> <Person id="rp01773" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Geneviève B.</DisplayName> <Person id="rp01779" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Elsevier</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>hypoxanthine</Keyword> <Keyword>alcohol</Keyword> <Keyword>antileishmanial agent</Keyword> <Keyword>antimalarial agent</Keyword> <Keyword>Calea montana extract</Keyword> <Keyword>Carica papaya extract</Keyword> <Keyword>Cestrum racemosum extract</Keyword> <Keyword>chloroquine</Keyword> <Keyword>Hedychium coronarium extract</Keyword> <Abstract>Aim of the study: Ninety-four ethanolic extracts of plants used medicinally by the Yanesha, an Amazonian Peruvian ethnic group, for affections related to leishmaniasis and malaria were screened in vitro against Leishmania amazonensis amastigotes and against a Plasmodium falciparum chloroquine resistant strain. Materials and methods: The viability of Leishmania amazonensis amastigote stages was assessed by the reduction of tetrazolium salt (MTT) while the impact on Plasmodium falciparum was determined by measuring the incorporation of radio-labelled hypoxanthine. Results and conclusions: Six plant species displayed good activity against Plasmodium falciparum chloroquine resistant strain (IC50 < 10 μg/ml): a Monimiaceae, Siparuna aspera (Ruiz & Pavon), A. DC., two Zingiberaceae, Renealmia thyrsoidea (Ruiz & Pavon) Poepp. & Endl. and Renealmia alpinia (Rottb.), two Piperaceae (Piper aduncum L. and Piper sp.) and the leaves of Jacaranda copaia (Aubl.) D. Don (Bignoniaceae). Eight species displayed interesting leishmanicidal activities (IC50 < 10 μg/ml): Carica papaya L. (Caricaceae), Piper dennisii Trel (Piperaceae), Hedychium coronarium J. König (Zingiberaceae), Cestrum racemosum Ruiz & Pav. (Solanaceae), Renealmia alpinia (Rottb.) Zingiberaceae, Lantana sp. (Verbenaceae), Hyptis lacustris A. St.-Hil. ex Benth. (Lamiaceae) and Calea montana Klat. (Asteraceae). Most of them are used against skin affections by Yanesha people. Results are discussed herein, according to the traditional use of the plants and compared with data obtained from the literature.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
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13.448654 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
