The authors gratefully acknowledge the financial assistance of CONCYTEC from Peru and DSF-IRD (JEAI) from France. We express our thanks to members of the Yanesha community who were willing to share with us their knowledge about medicinal plants. The authors are grateful to Candy Ruiz from LID-UPCH, for technical assistance in plants extractions. Céline Valadeau, Adriana Pabon and Denis Castillo received grants from the Institut Franc¸ ais des Etudes Andines, Colciencias and the Belgian technical cooperation respectively. Part of this work was supported by a grant from the International Foundation for Sciences attributed to Dionicia Gamboa

Objective: A systematic review and meta-analysis was performed to evaluate the safety and efficacy of drug-eluting stents (DES) vs bare-metal stents (BMS) in atrial fibrillation (AF) patients. Methods: We systematically searched 5 engines until May 2019 for cohort studies and randomized controlled trials (RCTs). Primary outcomes were major bleeding and major adverse cardiac events (MACE) including cardiac death, myocardial infarction, target vessel revascularization (TVR) or stent thrombosis. Effects of inverse variance random meta-analyses were described with relative risks (RR) and their 95% confidence intervals (CI). We also stratified analyses by type (triple [TAT] vs dual [DAT]) and duration (short-vs long-term) of antithrombotic therapy. Results: Ten studies (3 RCTs; 7 cohorts) including 10,353 patients (DES: 59.6%) were identified. DES did not show higher risk of major bleeding th...