In sanitary services, medical act and procedures are main processes that influence persons’ health. Health care requires a series of clinical procedures based on scientific criteria, diagnosis and treatment determination and standardization so as to strenghten medical act, adequate use of resources and improving health providing quality.

Background: Doppler ultrasound of the uterine and fetoplacental circulation is an important tool to determine complications associated with fetal growth restriction and fetal distress due to hypoxemia or asphyxia as occurring with hypertensive disorders of pregnancy. Also fetal cardiac anomalies, placental malformations and umbilical cord alterations can be diagnosed. Objectives: To determine the predictive value of cerebroplacental index and Aranzio’s venous duct abnormal flow measured by Doppler ultrasound in patients with preeclampsia, in relation to adverse perinatal outcomes. Design: Prospective, non experimental, longitudinal, correlation study. Setting: Fetal Medicine and Prenatal Diagnosis Unit, High Risk Obstetrical Service, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru. Participants: Pregnant women with diagnosis of severe preeclampsia and their fetuses. ...

Introduction: Prenatal diagnosis includes all diagnosis used to detect congenital alterations in the fetus. Amniocentesis and study of chorionic villus sampling are the most common techniques used in prenatal diagnosis in order to detect chromosomal alterations in a fetus at risk because of mother’s age or presence of ultrasound markers. Objectives: To determine frequency of chromosomopathies and culture success in patients attended in a specialized centre. Design: Retrospective study. Setting: Reprogenetics SAC, Lima, Peru. Participants: Pregnant women with age above 35 years or with ultrasound markers of fetal anomalies. Interventions: In 118 patients attended from June 2007 through August 2010 data of frequency of chromosomopathies and culture success were analyzed as well as mean mother age, gestational age and indications of prenatal cytogenetic study. All amniotic fluid samples w...

Premature ovarian failure (POF) is defined as the loss of function of the ovaries before age 40, causing amenorrhea, high FSH levels and low estradiol levels. This review describes the genetic factors that predispose to POF, including anomalies in chromosome X and chromosome fragile X, defects in autosomal genes and in genes involved in the maturation of the ovarian follicle.

Background: Doppler ultrasound of the uterine and fetoplacental circulation is an important tool to determine complications associated with fetal growth restriction and fetal distress due to hypoxemia or asphyxia as occurring with hypertensive disorders of pregnancy. Also fetal cardiac anomalies, placental malformations and umbilical cord alterations can be diagnosed. Objectives: To determine the predictive value of cerebroplacental index and Aranzio’s venous duct abnormal flow measured by Doppler ultrasound in patients with preeclampsia, in relation to adverse perinatal outcomes. Design: Prospective, non experimental, longitudinal, correlation study. Setting: Fetal Medicine and Prenatal Diagnosis Unit, High Risk Obstetrical Service, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru. Participants: Pregnant women with diagnosis of severe preeclampsia and their fetuses. ...

Introduction: Prenatal diagnosis includes all diagnosis used to detect congenital alterations in the fetus. Amniocentesis and study of chorionic villus sampling are the most common techniques used in prenatal diagnosis in order to detect chromosomal alterations in a fetus at risk because of mother’s age or presence of ultrasound markers. Objectives: To determine frequency of chromosomopathies and culture success in patients attended in a specialized centre. Design: Retrospective study. Setting: Reprogenetics SAC, Lima, Peru. Participants: Pregnant women with age above 35 years or with ultrasound markers of fetal anomalies. Interventions: In 118 patients attended from June 2007 through August 2010 data of frequency of chromosomopathies and culture success were analyzed as well as mean mother age, gestational age and indications of prenatal cytogenetic study. All amniotic fluid samples w...

In sanitary services, medical act and procedures are main processes that influence persons’ health. Health care requires a series of clinical procedures based on scientific criteria, diagnosis and treatment determination and standardization so as to strenghten medical act, adequate use of resources and improving health providing quality.

Premature ovarian failure (POF) is defined as the loss of function of the ovaries before age 40, causing amenorrhea, high FSH levels and low estradiol levels. This review describes the genetic factors that predispose to POF, including anomalies in chromosome X and chromosome fragile X, defects in autosomal genes and in genes involved in the maturation of the ovarian follicle.

Antecedentes: La velocimetría Doppler de la circulación uterina y fetoplacentaria es una herramienta importante para evaluar complicaciones asociadas a la restricción del crecimiento intrauterino y otras formas de distrés fetal debidas a hipoxemia o asfixia, como el producido por los trastornos hipertensivos del embarazo. También puede diagnosticarse anomalías cardíacas fetales, otras malformaciones y alteraciones placentarias o del cordón umbilical. Objetivos: Determinar el valor predictivo del índice cerebro placentario y del flujo anormal del ductus venoso de Aranzio, medido por velocimetría Doppler, en pacientes con preeclampsia severa, en relación a un resultado perinatal adverso. Diseño: Estudio prospectivo, no experimental, longitudinal, de tipo correlacional. Lugar: Unidad de Medicina Fetal y Diagnóstico Prenatal, Servicio de Obstetricia de Alto Riesgo, Hospital Naci...

Objective: To ascertain the value of the cerebral umbilical ratio for identifying newborns with neonatal morbidity in pregnancies complicated by severe preeclampsia.Study design: A longitudinal and correlational study of 80 patients with severe preeclampsia (PA > 160/110, proteinuria 3 +) was performed by a Doppler study done by one operator within seven days before delivery. Resistance index of middle cerebral artery (MCA) and umbilical artery (UA) were used to calculate the cerebral umbilical ratio (CUR). CUR <1 was considered abnormal. These results were compared with adverse perinatal outcome.Results: Maternal characteristics were: age 32, parity 1, primigravid 40%, prenatal care 90% gestational age at enrollment 35+ - 2.8 weeks. Abnormal perinatal results were present in the 17,5% of patients studied. The probability of detection IUGR is 60%, oligohydramnios 56% and abdominal ...

The doppler velocimetry of venosus ductus has been used as an important tool to establish the ideal moment to interrupt high risk pregnancies associated with doppler velocimetry alteration of fetal and umbilical-placental compartments. Technical aspects of identifying DV are discussed in the present study.

Objetivo: Determinar el valor predictivo del Índice Cerebro Placentario y del flujo anormal del Ductus Venoso de Aranzio, medido por velocimetría Doppler, en pacientes con preeclampsia, en relación a un resultado perinatal adverso. Materiales y métodos: Estudio prospectivo, no experimental, longitudinal, de tipo correlacional. Se realizaron exámenes ultrasonográficos Doppler para determinar el Índice Cerebro Placentario y el flujo anormal del Ductus Venoso de Aranzio, en los 7 días previos al parto, en 160 pacientes con diagnóstico de preeclampsia severa admitidas en la Unidad de Medicina Fetal y Diagnóstico Prenatal del Servicio de Obstetricia de Alto Riesgo del Hospital Guillermo Almenara Irigoyen – EsSalud. El resultado perinatal adverso fue definido por los siguientes parámetros: Cesárea por SFA, APGAR menor 7 a los 5´, Líquido amniótico meconial, Oligohidramnios, pH...