Introduction: Burns constitute a global public health problem with high morbidity and mortality. Despite advances in management, metabolic, infectious and scar complications continue to represent a challenge. Objective: To describe the main clinical and surgical advances in the comprehensive approach to the burn patient, with emphasis on regenerative medicine strategies, tissue bioengineering and translational approaches. Methodology: A narrative review was performed by searching biomedical databases without time restriction, selecting studies on reconstructive surgery, cell therapy, tissue bioengineering and translational approaches in burns management. Results: Advanced strategies in resuscitation, ventilation and metabolic support were analyzed, highlighting the impact of fluid optimization, protective ventilation and specialized nutrition. Innovations in reconstructive surgery includ...