Objective: To determine the relative bioavailability of an oral formulation of multisource sulfamethoxazole 200 mg / 5 ml respect to the reference formulation Oryctolagus cuniculus L (albino rabbits). Material and methods: The samples studied consisted of 25 vials of suspension of sulfamethoxazole / trimethoprim multisource 200 mg: 40 mg / 5 ml T1 with the letter assigned to the batch 11070674; and as a reference (R) 25 flasks Bactrim suspension of 200 mg: 40 mg / 5 ml, RJ0774 batch. The protocol consisted of a single oral dose of 100 mg / kg of sulfamethoxazole 200 mg / 5 ml of each of the formulations to 12 albino rabbits after a 12 hour fasting, through an open design in two cross periods (T / R), randomized, double-blind study with a greater range of 5 half-lives between each administration, later to determine plasma concentrations of the drug in default until 12 hours by means of a ...

The aim of this study was to evaluate the salivary profile of HIV-infected patients with and without Highly Active Antiretroviral Treatment (HAART), evaluating the Symptoms of salivary hypofunction (Xerostomia, Dysgeusia, Dysphagia, and Susceptibility to develop ulcers oral), the Unstimulated Salivary Flow Rate, Salivary pH and Salivary Viscosity, establishing their relationship with the degree of immunosuppression as assessed by the Counting of lymphocyte CD4/μl. We evaluated 126 patients with HIV infection with HAART and without HAART who were attended at the Health Strategy for Prevention and Control of STI, HIV and AIDS at the Hospital Nacional Dos de Mayo, Lima- Peru. Patients without HAART had significantly higher rates of some salivary hypofunction Symptoms: Xerostomia , Dysgeusia Dysphagia) and Susceptibility to develop oral ulcers and significantly higher values of Salivary vis...

The aim of this study was to evaluate the salivary profile of HIV-infected patients with and without Highly Active Antiretroviral Treatment (HAART), evaluating the Symptoms of salivary hypofunction (Xerostomia, Dysgeusia, Dysphagia, and Susceptibility to develop ulcers oral), the Unstimulated Salivary Flow Rate, Salivary pH and Salivary Viscosity, establishing their relationship with the degree of immunosuppression as assessed by the Counting of lymphocyte CD4/μl. We evaluated 126 patients with HIV infection with HAART and without HAART who were attended at the Health Strategy for Prevention and Control of STI, HIV and AIDS at the Hospital Nacional Dos de Mayo, Lima- Peru. Patients without HAART had significantly higher rates of some salivary hypofunction Symptoms: Xerostomia , Dysgeusia Dysphagia) and Susceptibility to develop oral ulcers and significantly higher values of Salivary vis...