The observation of some patients suffering from systemic lupus erythematosus in which low numbers of creatinine was found despite having purges below normal, did I suspect that might affect the functional relationship between serum creatinine and its respective debugging. The presence of musculoskeletal syndromes francs in many patients with systemic lupus erythematosus, also justified the suspicion of a disorder of the metabolism of creatine cratinina.

Living Labs are innovation infrastructures where software companies and research organizations collaborate with lead users to design and develop new products and services. There is not any reference model related to the processes or practices to manage a living lab. This article presents a reference model to manage effectively the synergies of software companies with the other stakeholders participating in a living lab. The article describes the approach used to create the reference model through the analysis of a multiple case study considering six living labs and discusses the lessons learned during the creation of the process reference model.